Incidence of schizophrenia in Nottingham

Brewin, J.; Cantwell, Roch; Dalkin, T.; R, Fox; Medley, Ian; Glazebrook, Cris; Kwiecinski, Rosemary; Harrison, Glynn

doi:10.1192/bjp.171.2.140

Cited by 87 publications

(32 citation statements)

References 16 publications

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“…However, this was not the case, suggesting that 'nuclear' schizophrenia is more homogeneous and occurs at a very similar frequency in the different populations. In recent years, replications of the design of the WHO ten-country study using the same instruments and procedures have been carried out with very similar results by investigators in India (Rajkumar et al 1993), the Caribbean (Hickling & Rodgers-Johnson 1995;Mahy et al 1999), and the United Kingdom Brewin et al 1997). …”

Section: Incidencementioning

confidence: 84%

“…However, the data remain inconsistent or conflicting. Two studies Brewin et al 1997) provide prevalence and incidence data on urban areas that had been surveyed 5 years earlier (inner London) and 12 years earlier (Nottingham). The point prevalence in Hampstead increased from 4.7 per 1000 in 1986 to 5.1 per 1000 in 1991 but the 5-year interval between the two surveys may be too short for detecting any long-term trend.…”

Section: Declining Incidence Of Schizophreniamentioning

confidence: 99%

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Epidemiology of schizophrenia: the global burden of disease and disability

Jablensky

2000

European Archives of Psychiatry and Clinical Neuroscience

391

220

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Evidence from nearly a century of epidemiological research indicates that schizophrenia occurs in all populations with a prevalence in the range of 1.4 to 4.6 per 1000 and incidence rates in the range of 0.16-0.42 per 1000 population. Multi-centre studies conducted by the World Health Organization have highlighted important differences between 'Western' and 'Third World' populations as regards the course and outcome of the disorder, with a significantly better prognosis in the developing countries. The factors underlying the better outcome of schizophrenia in developing countries remain essentially unknown but are likely to involve interactions between genetic variation and specific aspects of the environment. These features place schizophrenia, along with diabetes, cancer and hypertension, into the group of genetically complex diseases which are characterised by polygenic transmission, locus heterogeneity and environmental contribution to causation. The emerging pattern of risk factors and antecedents of schizophrenia suggests multiple, mainly quantitative deviations from the average developmental trajectory, primarily in the areas of early neurodevelopment, cognitive ability and social behaviour. These deviations are compatible with the notion of non-specific background factors facilitating the operation of genetically determined causal pathways. Research likely to result in new insights should focus on the population distribution and behavioural effects of potential risk factors and markers suggested by biological and genetic research.

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Section: Incidencementioning

confidence: 84%

Section: Declining Incidence Of Schizophreniamentioning

confidence: 99%

Epidemiology of schizophrenia: the global burden of disease and disability

Jablensky

2000

European Archives of Psychiatry and Clinical Neuroscience

391

220

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“…A Nottingham, UK, study examining the incidence of first-episode psychotic disorders in two cohorts, 1978-80 and 1992-4, found that the age-standardised incidence rates for schizophrenia and related disorders was 0.14 per 1000 per year. 33 They found that the rate for all psychoses rose slightly (but not statistically significantly so) but the rate for schizophrenia only had a significant decline. This suggested that an apparent reduction in schizophrenia incidence over time was likely to be due to the range of other psychosis diagnoses being made in the later cohort.…”

Section: Incidence Of Psychosismentioning

confidence: 99%

“…This suggested that an apparent reduction in schizophrenia incidence over time was likely to be due to the range of other psychosis diagnoses being made in the later cohort. 33 A study of the annual incidence of schizophrenia and non-affective psychosis in London found a rate of 0.22 per 1000 [95% confidence interval (CI) 0.15 to 0.29 per 1000]. 34 In a recent Irish study, the annual incidence of all psychoses in people aged over 15 years was estimated to be 0.32 per 1000.…”

Section: Incidence Of Psychosismentioning

confidence: 99%

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Structural neuroimaging in psychosis: a systematic review and economic evaluation

Albon¹,

Tsourapas²,

Frew³

et al. 2008

Health Technol Assess

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