Incidence of second primary malignancies after a malignant tumor in childhood a population‐based survey in Piedmont (ITALY)

Magnani, Corrado; Terracini, Benedetto; Montezemolo, Luca Cordero di; Gallone, Giovanni; Luzzatto, Lia; Mosso, Maria Luisa; Pastore, Guido; Rosso, Paolo

doi:10.1002/(sici)1097-0215(19960703)67:1<6::aid-ijc2>3.3.co;2-k

Cited by 7 publications

(12 citation statements)

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“…The Childhood Cancer Registry of Piedmont, Italy, observed 18 second primaries vs . 2.81 expected for an overall SIR of 6.4 (95% CI = 3.8–10.1) in 2,328 persons affected by an antecedent malignancy at ages 0–14 years between 1967 and 1989,3 while an SIR of 12.5 (O/E = 127/10.1; 95% CI = 10.4–14.9) was shown by 20,388 childhood cancer patients ascertained by the German Children's Cancer Registry in the period 1980–1995 4…”

Section: Discussionmentioning

confidence: 98%

“…Individuals who suffered from a first primary malignancy in childhood or adolescence exhibit an increased risk of developing a second primary in comparison with the general population 1, 2, 3, 4, 5. The major determinants of subsequent primary cancer in the young are inherited susceptibility and initial cancer therapies, particularly ionizing radiation and chemotherapy with their carcinogenicity 6…”

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confidence: 99%

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Family history of cancer and risk of second malignancies in young cancer patients in Trieste, Italy

Brunetti¹,

Tamaro

Fanin

et al. 2005

Intl Journal of Cancer

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We carried out a cohort study in the Italian province of Trieste (2001 population, 242,000) to ascertain whether the risk of a subsequent primary cancer among 265 individuals diagnosed with a first malignancy at ages up to 25 years between 1971 and 1993 differed from that in the general population and to evaluate the effect of cancer family history, quantified by the family risk index (FRI), on the occurrence of second primaries. During the follow-up (median duration = 10 years; 25th-75th percentile = 2-16), 15 cohort members developed a second cancer vs. 1.60 expected for a standardized incidence ratio (SIR) of 9.4 (p < 0.0001). The overall SIR fell to 4.7 (p = 0.004) after excluding the 8 patients with wellknown cancer-predisposing conditions (SIR = 300.0; p < 0.0001) and the 50 with a positive family history (FRI ! 1.0) of malignant tumors (SIR = 20.0; p < 0.0001). Among 114 patients treated with radiotherapy and chemotherapy for their first neoplasms and not affected by predisposing disorders, 23 with a positive family history of cancer showed a 6.4-fold excess risk of second primaries (p = 0.008) compared with 91 with a negative history (FRI < 1.0). It is imperative that clinicians carefully and regularly evaluate cancer family history of young patients with malignancies. This would enable them to identify possible individual and familial features in patients at higher risk of multiple primaries and to adopt more suitable preventive and therapeutic measures. ' 2005 Wiley-Liss, Inc.Key words: second primary cancer; family risk index; children; adolescents; young adults Individuals who suffered from a first primary malignancy in childhood or adolescence exhibit an increased risk of developing a second primary in comparison with the general population. 1-5 The major determinants of subsequent primary cancer in the young are inherited susceptibility and initial cancer therapies, particularly ionizing radiation and chemotherapy with their carcinogenicity. 6 In spite of several studies substantiating the association between the occurrence of second malignant neoplasms in young patients and well-known hereditary predisposing disorders 7-12 and exposure to therapeutic radiation or antineoplastic drugs, 10,11,[13][14][15][16][17][18][19][20][21][22][23] only one epidemiologic study investigating the risk of second primaries in relation to the extent of cancer clustering in young patients' relatives has been published to our knowledge. 24 The present cohort study is based on young people living in the northeastern Italian province of Trieste who developed a first primary malignancy during the period 1971-1993. The study aims at determining the effect of cancer risk found in their nuclear families on the incidence of second malignant neoplasms. Material and methodsAll permanent residents of the province of Trieste (2001 population, 242,000) diagnosed with a first primary cancer at ages 0-25 years between 1 January 1971 and 31 December 1993 were extracted from the file of the general population-based Cancer Registry ...

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Section: Discussionmentioning

confidence: 98%

mentioning

confidence: 99%

Family history of cancer and risk of second malignancies in young cancer patients in Trieste, Italy

Brunetti¹,

Tamaro

Fanin

et al. 2005

Intl Journal of Cancer

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“…While the SPN standardised incidence ratios (SIRs) in children range from three‐ to sixfold of that expected, the SIRs are substantially smaller in AYA, with the Surveillance, Epidemiology, and End Results (SEER) program reporting an SIR of 1.6 among 15‐39 year olds (corresponding SIR in children in SEER = 4.3) . Excess risk of SPNs varies substantially when assessed by the type of SPN and by the interval from diagnosis of index cancer.…”

Section: Risks Of Adverse Physical Outcomes In Survivors Of Aya Cancermentioning

confidence: 99%

“…While the SPN standardised incidence ratios (SIRs) in children range from three-to sixfold of that expected, [27][28][29][30][31][32][33][34][35] 26,28 There are a number of factors that may be related to these differences, including the potential for greater toxicity in tissue and organs exposed to cancer treatments whilst still developing and the different spectrum of malignant diseases predominating in childhood and AYA and the consequent different treatment exposures.…”

Section: Subsequent Primary Neoplasmsmentioning

confidence: 99%

Challenges and opportunities in the care of survivors of adolescent and young adult cancers

Fidler

Frobisher

Hawkins

et al. 2019

Pediatric Blood & Cancer

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Adolescents and young adults (AYA) with cancer are an understudied group. Much of what is known about long‐term outcomes after AYA cancer has been derived from cohorts of childhood cancer survivors, which seldom include patients at the older end of the AYA age spectrum. In general, AYA cancer survivors have a lower risk for premature mortality, subsequent primary neoplasms and chronic health conditions than childhood cancer survivors. However, AYA cancer survivors are vulnerable to psychosocial challenges, concerns about fertility and relationships and financial toxicity. No single model is optimal for the care of these survivors, but it is generally agreed that all survivors require a survivor care plan that promotes their adherence to evidence‐based surveillance guidelines. There is a need to create survivor cohorts that include the full range of AYA ages and diagnoses to be able to address the many pressing questions that remain unanswered in this vulnerable population.

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“…At 10 years 94% (CI 91-96%) remain alive; 25 deaths have been reported, of which 21 were due to recurrent tumour. At time of analysis no second malignancies had been reported, though in the longer term it is likely that some will occur, particularly in patients who received more intensive therapies [9,10].…”

Section: Discussionmentioning

confidence: 99%

Late relapse and prognosis for neuroblastoma patients surviving 5 years or more: A report from the European Neuroblastoma Study Group ?Survey?

Cotterill

Pearson

Pritchard³

et al. 2001

Med. Pediatr. Oncol.

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Incidence of second primary malignancies after a malignant tumor in childhood a population‐based survey in Piedmont (ITALY)

Cited by 7 publications

References 0 publications

Family history of cancer and risk of second malignancies in young cancer patients in Trieste, Italy

Family history of cancer and risk of second malignancies in young cancer patients in Trieste, Italy

Challenges and opportunities in the care of survivors of adolescent and young adult cancers

Late relapse and prognosis for neuroblastoma patients surviving 5 years or more: A report from the European Neuroblastoma Study Group ?Survey?

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