Incidence of Sentinel Node Metastasis in Patients With Thin Primary Melanoma (#1 mm) With Vertical Growth Phase

Bedrosian, Isabelle; Faries, Mark B.; Guerry, D.; Elenitsas, Rosalie; Schuchter, Lynn M.; Mick, Rosemarie; Spitz, Francis R.; Bucky, Louis P.; Alavi, Abass; Elder, David E.; Fraker, Douglas L.; Czerniecki, Brian J.

doi:10.1007/s10434-000-0262-z

Cited by 162 publications

(101 citation statements)

References 21 publications

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“…5,6 Vertical growth phase, high mitotic rate, and regression are other factors that may increase the risk of recurrence or metastasis of melanoma. 5,7,8 Sentinel lymph node biopsy is currently recommended for patients with melanomas that have a Breslow depth 41 mm or r1 mm when there is ulceration or Clark's level IV or V invasion. 9 Both greater Breslow depth and metastatic melanoma in sentinel lymph nodes are associated with a worse prognosis.…”

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confidence: 99%

IMP-3 is a novel progression marker in malignant melanoma

et al. 2008

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Insulin-like growth factor-II messenger RNA (mRNA)-binding protein-3 (IMP-3), also known as K homology domain-containing protein overexpressed in cancer (KOC) and L523S, is a member of the insulin-like growth factor-II mRNA-binding protein family and is expressed during embryogenesis and in some malignancies. IMP-3 expression in melanocytic neoplasms has not been investigated. Fifty-six melanocytic neoplasms from 48 subjects were immunohistochemically studied using a monoclonal antibody against L523S/IMP-3. IMP-3 expression in melanoma was significantly higher than in Spitz nevi (Po0.05), and the staining intensity in the Spitz nevi was weak. IMP-3 expression in metastatic melanoma was significantly higher than in primary cutaneous melanoma with a Breslow depth r1 mm (Po0.01). None of the benign nevi and dysplastic nevi expressed IMP-3. Our study demonstrates that IMP-3 is expressed in malignant melanoma but not in benign nevi, even when dysplastic features are present; IMP-3 is expressed in a significantly higher proportion of melanomas than Spitz nevi; and IMP-3 is expressed in metastatic melanomas significantly more than in thin melanomas. In conclusion, IMP-3 appears to be involved in the progression of malignant melanoma and may play an important role in the regulation of the biologic behavior of this tumor. Additionally, IMP-3 may have diagnostic utility in distinguishing melanoma from benign nevic cells, dysplastic nevi, and Spitz nevi.

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confidence: 99%

IMP-3 is a novel progression marker in malignant melanoma

et al. 2008

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“…Se realizó biopsia del ganglio centinela a todos aquellos pacientes a los que se les habían diagnosticado y extirpado melanomas con espesor tumoral (Breslow) superior o igual a 1 mm y que no presentasen adenopatías palpables al diagnóstico. Además, debido a que un porcentaje importante de pacientes (6%) con melanomas de menos de 1 mm de espesor han demostrado tener metástasis subclínicas al efectuarse la biopsia del ganglio centinela (16) , se incluyeron de forma individualizada pacientes con menor espesor acompañados de algún otro criterio de riesgo como crecimiento vertical temprano, ulceración, mitosis, nivel IV de Clark y regresión extensa, según indican los nuevos protocolos de actuación en la prevención y tratamiento del melanoma (10,17) .…”

Section: Métodosunclassified

Relationship between positive sentinel lymph node and Breslow's depth in patients with primary cutaneous melanoma

Kronau-Manzoni

Gómez-Argumosa

Barrios

et al. 2017

Rev. Nac. (Itauguá)

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RESUMENIntroducción: es sabido que el pronóstico del melanoma cutáneo depende, entre otros factores, de la existencia de diseminación linfática a ganglios. La biopsia del ganglio centinela busca identificar metástasis ganglionares subclínicas.Objetivo: el presente estudio tuvo por objetivo analizar la asociación entre la presencia de ganglio centinela positivo, identificado mediante rastreo con radioisótopo 99mTc-coloide de Renio, y el espesor de Breslow hallado en la lesión primaria a nivel cutáneo. Conclusiones: a medida que aumenta el espesor de Breslow, lo hace también el encuentro de metástasis en ganglio centinela. Se recomienda realizar estudios de casos y controles para evaluar el factor predictivo que puede llegar a tener el encontrar ganglio centinela positivo. MetodologíaPalabras claves: ganglio centinela, espesor de Breslow, melanoma cutáneo. ABSTRACTIntroduction: It is known that the prognosis of cutaneous melanoma depends, among other factors, on the existence of lymphatic spread to lymph nodes. Sentinel node biopsy seeks to identify subclinical lymph node metastases. Objective:The present study aimed to analyze the association between the presence of positive sentinel lymph node, identified by Rhenium 99mTc-colloid radioisotope tracing, and the Breslow´s depth found in the primary lesion at the cutaneous level. Conclusions: As Breslow's depths increases, so does the metastasis encounter in sentinel lymphs nodes. It is recommended to carry out case-control studies to evaluate the predictive factor that may result in finding a positive sentinel lymph node. Rev. Nac. (Itauguá

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“…6 O status do LNS é tão aceito, que foi incluído no estadiamento proposto pela American Joint Committee on Cancer for Malignant Cutaneous Melanoma. 24,25 A detecção de LNS pode ser também indicada para pacientes com lesões mais superficiais (<1mm), 26,27 apesar de ser evidente o fato de que tumores mais profundos apresentam maior probabilidade de disseminação ganglionar. 28,29 O valor prognóstico da biópsia do linfonodo sentinela é comprovado para tumores com espessura acima de 4mm.…”

Section: Impacto Da Biópsia Do Lns No Estadiamento E Prognóstico Do Munclassified

“…21,22 The specific use of SNL 24,25 SNL detection may also be indicated for patients with more superficial lesions (<1mm), 26,27 in spite of the obvious fact that deeper tumors are more likely to show ganglionar dissemination. 28,29 The prognostic value of sentinel node biopsy is confirmed for thick (>/=4-mm) tumors.…”

Section: Impacto Da Biópsia Do Lns No Estadiamento E Prognóstico Do Mmentioning

confidence: 99%

Pesquisa do linfonodo sentinela em pacientes com melanoma: experiência com fitato marcado com Tecnécio-99m e revisão da literatura

Sapienza¹,

Tavares²,

Endo³

et al. 2004

An. Bras. Dermatol.

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Resumo: FUNDAMENTOS -A progressão linfática do melanoma maligno habitualmente se inicia pelo linfonodo sentinela (LNS), cuja análise histopatológica permite predizer o acometimento de toda a cadeia. OBJETIVO Tc-Fitato, que apresenta vantagens de custo e disponibilidade no Brasil. A pesquisa de LNS resulta em maior acurácia e menor morbidade no estadiamento de pacientes com melanoma maligno Palavras-chave: biópsia de linfonodo sentinela; cintilografia; melanoma. Summary: BACKGROUND -Sentinel lymph node (SLN), corresponding to the first lymph node draining the tumor, is usually the first one to receive its metastasis, and its biopsy is used to define the status of the whole lymphatic basin. OBJECTIVE -The aim of this paper is to describe the use 99mTc-Fitato in SLN

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Incidence of Sentinel Node Metastasis in Patients With Thin Primary Melanoma (#1 mm) With Vertical Growth Phase

Cited by 162 publications

References 21 publications

IMP-3 is a novel progression marker in malignant melanoma

IMP-3 is a novel progression marker in malignant melanoma

Relationship between positive sentinel lymph node and Breslow's depth in patients with primary cutaneous melanoma

Pesquisa do linfonodo sentinela em pacientes com melanoma: experiência com fitato marcado com Tecnécio-99m e revisão da literatura

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