2020
DOI: 10.3390/medicina56060262
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Incidence of Severe Chronic Neutropenia in South Korea and Related Clinical Manifestations: A National Health Insurance Database Study

Abstract: Background and objectives: Severe chronic neutropenia (SCN) is a condition in which absolute neutrophil counts remain at a low level (under 500/µL) over months or years. Because of the rare onset of SCN, its epidemiology, prognosis, and clinical manifestations have not yet been fully understood. In particular, large-cohort studies in Asian countries are still insufficient. Therefore, in this study, national health insurance data was used to investigate the epidemiologic features and prognosis of SCN in South K… Show more

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Cited by 2 publications
(3 citation statements)
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“…The main cause of hospital admission before establishing the diagnosis was URTI, which was consistent with a previous report that described all seven patients who suffered from recurrent URTI during the first six months (1) . In a study in which chronic severe neutropenia cases were examined, URTIs were the most common cause of complaints (2) .…”
Section: Discussionmentioning
confidence: 99%
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“…The main cause of hospital admission before establishing the diagnosis was URTI, which was consistent with a previous report that described all seven patients who suffered from recurrent URTI during the first six months (1) . In a study in which chronic severe neutropenia cases were examined, URTIs were the most common cause of complaints (2) .…”
Section: Discussionmentioning
confidence: 99%
“…Severe congenital neutropenia (SCN) and cyclic neutropenia (CyN) are two major types of CN encountered in childhood (1) . Because of the rare onset of SCN, its epidemiology, prognosis and clinical manifestations have not yet been fully understood (2) . SCN encompasses a group of disorders that are characterized by peripheral neutrophil counts of <0.5×10 9 /L, early-onset recurrent bacterial infection and bone marrow maturation arrest of myelopoiesis at the promyelocyte/myelocyte stage (2) .…”
Section: Introductionmentioning
confidence: 99%
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