Incidence of soft tissue sarcoma in Taiwan: A nationwide population-based study (2007–2013)

Hung, Giun Yi; Horng, Jiun Lin; Chen, Paul Chih Hsueh; Li, Lin; Chen, Jinn Yang; Chuang, Pei Hung; Chao, Ta‐Chung; Yen, Chueh Chuan

doi:10.1016/j.canep.2019.04.007

Cited by 18 publications

(21 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a study that used data from a national population‐based database, Hung et al reported that the incidence of AS in Taiwan was higher compared with SEER or European data 10 . However, it is uncertain in Asia if cutaneous or visceral AS was more common.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9] Despite a higher prevalence of cutaneous AS in our cohort who had In a study that used data from a national population-based database, Hung et al reported that the incidence of AS in Taiwan was higher compared with SEER or European data. 10 However, it is uncertain in Asia if cutaneous or visceral AS was more common. In our advanced AS cohort, 55% of patients had a cutaneous primary origin.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The treatment landscape of advanced angiosarcoma in Asia—A multi‐national collaboration from the Asian Sarcoma Consortium

et al. 2021

View full text Add to dashboard Cite

Angiosarcoma (AS) is a rare disease with a dismal prognosis. The treatment landscape and prognostic factors for advanced AS, including locally advanced, unresectable, and metastatic disease remain elusive. The Asian Sarcoma Consortium is an international collaborative effort to understand the sarcoma treatment landscape in Asia. We undertook a retrospective chart review of AS patients seen in 8 sarcoma academic centers across Asia. Patients with complete clinical, treatment, and follow‐up data were enrolled. Overall, 276 advanced AS patients were included into this study; 84 (30%) of the patients had metachronous metastatic AS. The median age was 67 y; primary sites of AS was cutaneous in 55% and visceral in 45% of patients. In total, 143 (52%) patients received at least 1 line of systemic chemotherapy. The most common first‐line chemotherapy regimen used was paclitaxel (47.6%) followed by liposomal doxorubicin (19.6%). The median overall survival (OS) was 7.8 mo. Significant prognostic factors for OS included age > 65 (hazard ratio (HR) 1.54, P = .006), male gender (HR 1.39, P = .02), and a cutaneous primary AS site (HR 0.63, P = .004). The median progression‐free survival (PFS) for first‐line chemotherapy was 3.4 mo. PFS for single vs combination or paclitaxel vs liposomal doxorubicin chemotherapy regimens were comparable. This study provides an insight into the treatment patterns and prognostic factors of advanced AS patients in Asia. Prognosis of advanced AS remains poor. Data from this study serve as a benchmark for future clinical study design.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The treatment landscape of advanced angiosarcoma in Asia—A multi‐national collaboration from the Asian Sarcoma Consortium

et al. 2021

View full text Add to dashboard Cite

show abstract

“…2021; 14(5):e110504. tries (3.3 -4.7/100000), Taiwan (5.62/100000), Switzerland (4.47/100000), Ireland (4.48/10000), and three European regions (4.58/100000 for males and 5.12/100000 for females) (6,17,(19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

Sarcomas Epidemiology in Iran: Analysis of Data from Iranian National Cancer Registry between 2009 and 2014

et al. 2021

View full text Add to dashboard Cite

Background: Sarcomas are a wide group of tumors with a mesenchymal origin, accounting for 1% of all adult malignancies. Objectives: This study examined the incidence rates and distribution patterns of morphological subtypes and primary sites of soft tissue and bone sarcomas in a 6-years period in the total population of Iran. Methods: The data was retrieved from the Iranian National Cancer Registry (INCR). A total of 14630 patients were identified with either bone or soft tissue sarcoma during 2009 - 2014. The morphological and topographical classifications were based on the ICD-O-3 and World Health Organization (WHO) guidelines. The crude and age-standardized incidence rates (ASIR) were calculated. Results: The combined crude incidence was calculated 3.2/100,000, and for STS and BS was 2.7 and 0.5 per 100,000 individuals, respectively, increasing with the age. Among the patients, 16.47 and 83.53% of cases had BS and STS, respectively with male predilection. The ASIR calculated 2.8 and 2.6 for STS and 0.51 and 0.37 for BS in males and females, respectively. Sarcoma, osteosarcoma, leiomyosarcoma, liposarcoma, and spindle cell sarcoma were the most common morphologies. The connective tissue of the lower limb, long bone of the lower limb, skin, and uterus were the most frequent primary tumor sites. The majority of tumors were of unknown/undifferentiated grade (grade 9), then grade 3, 1, 2, 4, and score 0 had the highest frequencies, respectively. The highest ASIR of sarcoma was detected in Khuzestan, Kohgiloyeh and Boyer-Ahmad, Isfahan, Tehran, Fars, and Khorasan Razavi provinces. Analysis of the incidence trends showed a slight increase over the study period. Conclusions: These findings can help better diagnose and management of sarcoma patients throughout Iran.

show abstract

“…Synovial sarcoma is a type of soft tissue sarcoma that can occur anywhere in the body [1]. It is a rare disease, with an estimated annual incidence of 1.1 to 1.7 cases per million people in the United States, Switzerland, the EU and Taiwan [1,2]. Although it is rare, synovial sarcoma is most common in adolescents and young adults, with a median age at diagnosis of 35 years; notably, 17.6% of synovial sarcomas are diagnosed in patients under 20 years of age [3].…”

Section: Introductionmentioning

confidence: 99%

Marine Antimicrobial Peptide TP4 Exerts Anticancer Effects on Human Synovial Sarcoma Cells via Calcium Overload, Reactive Oxygen Species Production and Mitochondrial Hyperpolarization

Hung

et al. 2021

Marine Drugs

Self Cite

View full text Add to dashboard Cite

Synovial sarcoma is a rare but aggressive soft-tissue sarcoma associated with translocation t(X;18). Metastasis occurs in approximately 50% of all patients, and curative outcomes are difficult to achieve in this group. Since the efficacies of current therapeutic approaches for metastatic synovial sarcoma remain limited, new therapeutic agents are urgently needed. Tilapia piscidin 4 (TP4), a marine antimicrobial peptide, is known to exhibit multiple biological functions, including anti-bacterial, wound-healing, immunomodulatory, and anticancer activities. In the present study, we assessed the anticancer activity of TP4 in human synovial sarcoma cells and determined the underlying mechanisms. We first demonstrated that TP4 can induce necrotic cell death in human synovial sarcoma AsKa-SS and SW982 cells lines. In addition, we saw that TP4 initiates reactive oxygen species (ROS) production and downregulates antioxidant proteins, such as uncoupling protein-2, superoxide dismutase (SOD)-1, and SOD-2. Moreover, TP4-induced mitochondrial hyperpolarization is followed by elevation of mitochondrial ROS. Calcium overload is also triggered by TP4, and cell death can be attenuated by a necrosis inhibitor, ROS scavenger or calcium chelator. In our experiments, TP4 displayed strong anticancer activity in human synovial sarcoma cells by disrupting oxidative status, promoting mitochondrial hyperpolarization and causing calcium overload.

show abstract

Incidence of soft tissue sarcoma in Taiwan: A nationwide population-based study (2007–2013)

Cited by 18 publications

References 20 publications

The treatment landscape of advanced angiosarcoma in Asia—A multi‐national collaboration from the Asian Sarcoma Consortium

The treatment landscape of advanced angiosarcoma in Asia—A multi‐national collaboration from the Asian Sarcoma Consortium

Sarcomas Epidemiology in Iran: Analysis of Data from Iranian National Cancer Registry between 2009 and 2014

Marine Antimicrobial Peptide TP4 Exerts Anticancer Effects on Human Synovial Sarcoma Cells via Calcium Overload, Reactive Oxygen Species Production and Mitochondrial Hyperpolarization

Contact Info

Product

Resources

About