Incidence of specific etiology and role of methods for specific etiologic diagnosis of primary acute pericarditis

Zayas, Ricardo; Anguita, Manuel; Torres, Francisco; ́nez, Diego Gime; Bergillos, F; Ruiz, Marti ́n; Ciudad, Mar; Gallardo, Arsenio; ́s, Federico Valle

doi:10.1016/s0002-9149(99)80558-x

Cited by 255 publications

(155 citation statements)

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“…Previous studies have reported conflicting results on the effect of sex on the risk of pericarditis. [5][6][7] A recent randomized trial of 240 patients with acute pericarditis found 60% were male, 6 whereas previous studies have reported higher male prominence 7 but also female prominence. 5 We found 65% of 1361 patients to be male, and the age-adjusted likelihood of an acute pericarditis patient being male was 1.9.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Experimental studies have found males to be at higher risk for acute viral heart disease, 3,4 but clinical studies have reported conflicting results on sex distribution of acute pericarditis patients. [5][6][7] It is commonly thought that there is no specific sex predisposition to pericarditis. 8 Murine studies have also found the susceptibility for viral heart disease to be significantly age dependent, with the highest sensitivity at adolescence or young adulthood.…”

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confidence: 99%

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Clinical Profile and Influences on Outcomes in Patients Hospitalized for Acute Pericarditis

2014

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Background-The clinical profile with regard to sex and the influences on outcomes in patients who have been hospitalized for acute pericarditis is largely uncharacterized. Methods and Results-We studied all patients aged ≥16 years admitted to the hospital because of acute pericarditis (postpericardiotomy and myocardial infarction associated pericarditis were excluded). Data were collected from a Finnish national registry that included data on all cardiovascular admissions (670 409

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Clinical Profile and Influences on Outcomes in Patients Hospitalized for Acute Pericarditis

2014

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“…We used body mass index (BMI) calculated directly from weight and height records (weight/height2) and created 4 categories: underweight (BMI <18.5), normal weight (BMI=18.5–24.9), overweight (BMI=25.0–29.9), and obesity (BMI >30), using World Health Organization (WHO) grouping of overweight and obesity. Details on processing, cleaning, and representativeness of CPRD BMI data have been previously described 8, 11.…”

Section: Methodsmentioning

confidence: 99%

“…Acute pericarditis mainly affects the younger population, and it is usually benign and self‐limiting. However, pericarditis with effusion is a known complication to lung and breast cancer and has been reported also in patients with hematological malignancies, primary cardiac tumors, gastrointestinal cancer, and urogenital cancer 1, 2. The connection may stem from direct extension of cancer cells from nearby structures or hematogenous spread of abnormal cancer cells through the bloodstream 3.…”

Section: Introductionmentioning

confidence: 99%

Acute Pericarditis and Cancer Risk: A Matched Cohort Study Using Linked UK Primary and Secondary Care Data

Søgaard

Sørensen

Smeeth

et al. 2018

JAHA

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BackgroundWe aimed to examine whether acute pericarditis is an indicator of undetected cancer and identify patient‐level factors associated with high cancer risk among patients presenting with pericarditis.Methods and ResultsA population‐based matched cohort study was conducted using primary care data from the UK Clinical Practice Research Datalink linked to Hospital Episode Statistics. Patients with acute pericarditis (n=6530) were matched to a comparison cohort (n=26 111) on age, sex, calendar time, and general practice. We estimated cumulative cancer incidences, and calculated hazard ratios using Cox regression. Effect modification by patients' characteristics and lifestyle factors was examined, and we fitted a parsimonious model to evaluate absolute excess risk of later cancer among pericarditis patients by key patient‐level factors. We identified 728 and 1379 incidents of cancer among pericarditis patients and the comparison cohort (median follow‐up, 2.8 and 3.5 years). Pericarditis was associated with an elevated subsequent risk of any cancer (hazard ratio=3.03; 95% confidence interval, 2.74–3.36). The association was particularly pronounced 0 to 3 months after pericarditis (hazard ratio=23.56; 95% confidence interval, 18.00–30.83), but a more‐modest association remained thereafter (hazard ratio=1.95; 95% confidence interval, 1.48–2.57 after 3–12 months, and hazard ratio=1.40; 95% confidence interval, 1.21–1.62 after >12 month). Older individuals hospitalized with pericarditis and with combinations of obesity and smoking were at the highest excess risk of having a cancer diagnosis 3 to 12 months later, reaching 4.8%.ConclusionsOccult cancers may be going undiagnosed during the acute episode of pericarditis. Patients presenting with pericarditis and combinations of older age, obesity, smoking, and a need for hospitalization might warrant targeted investigations for cancer.

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“…Purulent pericarditis is present in a wide variety of pathological conditions with varying etiologies such as immunosuppression and chronic diseases (e.g., alcohol abuse, rheumatoid arthritis), but is commonly secondary to injury, cardiac procedures, or insult to the pericardium [1][2][3]. There is considerable urgency to establish a correct diagnosis, because if left untreated, the combination of tamponade and sepsis results in a mortality rate approaching 100% [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Bacterial pericarditis and antimicrobial resistance at the Tehran Heart Center, Iran

Anvari

Kianinejad

Boroumand

et al. 2015

J Infect Dev Ctries

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Introduction: When bacterial pericarditis is suspected, urgent pericardial drainage combined with intravenous antibacterial therapy is mandatory to avert devastating, life-threatening complications. There have been scanty results on antimicrobial susceptibility of common causative microorganisms of bacterial pericarditis; most studies had small sample sizes and were performed decades ago. Methodology: This prospective study surveyed the causative bacteria in infectious pericardial effusions and their antimicrobial susceptibility among 320 consecutive cardiac patients who underwent pericardiocentesis at Tehran Heart Center between 2007 and 2012, using the European Society of Cardiology (ESC)'s criteria. Results: Staphylococcus spp. (S. epidermidis, S. aureus, S. haemolyticus) were the main causative organisms isolated from cultures of pericardial effusion samples. Other causative organisms were Streptococcus spp., Enterococcus faecium, Pseudomonas aeruginosa, and Acinetobacter baumannii. In the cultures studied, 35% methicillin-resistant Staphylococcus epidermidis (MRSE) and 42.9% methicillinresistant Staphylococcus aureus (MRSA) were detected. The most effective antimicrobial agents in S. epidermidis were gentamicin, ciprofloxacin, and cefoxitin. Clindamycin was relatively effective. S. aureus was highly susceptible to clindamycin and erythromycin. In cases of S. haemolyticus infection, clindamycin, erythromycin, cefoxitin, and ciprofloxacin were effective antibiotics. Conclusions: In order to diminish the nascence and extension of antimicrobial-resistant pathogens, logical and optimized antimicrobial usage and monitoring in hospitals are highly recommended. It is incumbent on healthcare systems to determine current local resistance patterns by which to guide empiric antimicrobial therapy for specific infections and microorganism types.

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Incidence of specific etiology and role of methods for specific etiologic diagnosis of primary acute pericarditis

Cited by 255 publications

References 10 publications

Clinical Profile and Influences on Outcomes in Patients Hospitalized for Acute Pericarditis

Clinical Profile and Influences on Outcomes in Patients Hospitalized for Acute Pericarditis

Acute Pericarditis and Cancer Risk: A Matched Cohort Study Using Linked UK Primary and Secondary Care Data

Bacterial pericarditis and antimicrobial resistance at the Tehran Heart Center, Iran

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