The early diastolic filling characteristics and pressure (as measured at the chest wall) were studied in 17
normal subjects with a physiologic third heart sound (Phy S(3)) and were compared in 13 normal subjects without this
sound (controls; C). Simultaneous M-mode echocardiogram, apex phonocardiogram, calibrated apexcardiogram
(ACG), and its first derivative were recorded. The maximum rate of change of ventricular dimension (max dD/dt)
was derived by computer and normalized (max dD/dt/D). The Phy S(3) occurred during the early E-F slope of the
mitral valve echocardiogram, followed max dD/dt, and was recorded between the O and F points of the calibrated
ACG in all 17 subjects. In 14 of 17 subjects, the Phy S(3) was associated with an inflection on septum, posterior wall, or
mitral valve apparatus. Compared to C, there was no significant difference in the subjects’ age, systolic or diastolic
dimensions, ejection fraction, or diastolic time intervals. However, both pre-ejection period and the ratio preejection
period/left ventricular ejection time were significantly shortened in subjects with the Phy S(3). There was no
significant difference in any of the computer-derived indices of diastolic filling, including max dD/dt, max dD/dt/D,
the interval from mitral valve opening to 20% max dD/dt, and the percent diastolic dimension change at the O point
of the ACG. There was also no significant difference in any of the indices of mitral valve velocity. However, the
maximal rate of change of pressure during the rapid filling wave of the calibrated ACG was markedly increased in the
subjects with the Phy S3 compared to C (787 ± 296 vs. 296 ± 98 mm Hg/s; p < 0.001). These data are consistent
with the thesis that the genesis of the Phy S(3) is due to the dynamic impact of the heart on the chest wall. The force of
this impact and the resultant intensity of the Phy S(3) are determined by both chest wall configuration and motion of
the heart within the thorax.