Incidence of Thyroid Disorders in Connecticut

Baldwin, David B.

doi:10.1001/jama.1978.03280350066018

Cited by 36 publications

(9 citation statements)

References 5 publications

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“…The prevalence of morphological abnormalities of the thyroid gland in the general population [22,23] is much lower than that found in our study of patients who received mantle irradiation. Brander et al [24] found thyroid nodules in 35% of healthy females with an average age of 52 years.…”

Section: Discussioncontrasting

confidence: 85%

Comparing thyroid ultrasonography to thyroid function in long‐term survivors of childhood lymphoma

Solt

Gaitini

Pery

et al. 2000

Med. Pediatr. Oncol.

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Both ultrasound and thyroid function tests independently provide clinically useful information; the former examines gland morphologogy and the latter evaluates hormonal changes associated with thyroid disease. The high frequency of thyroid abnormalities detected by ultrasonography suggests that periodic thyroid ultrasonography is advisable in the follow-up of patients treated with mantle irradiation to screen for morphologic changes that may presage malignant transformation.

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Section: Discussioncontrasting

confidence: 85%

Comparing thyroid ultrasonography to thyroid function in long‐term survivors of childhood lymphoma

Solt

Gaitini

Pery

et al. 2000

Med. Pediatr. Oncol.

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“…Our prevalence rate is, however, a little lower compared to that of dos Remedios et al, namely 6.1/1000 females and 3.5/1000 males, which was estimated by screening clinic patients using free thyroxine index, 13 but similar to that of Baldwin and Rowett. 17 The prevalence rates in non-Saudis as compared to Saudis were lower in females but higher in males. This could be a reflection of the age and sex distribution of non-Saudis in the Kingdom as well as the diversity of their nationalities.…”

Section: Discussionmentioning

confidence: 95%

Clinical Presentation of Spontaneous Primary Hypothyroidism in Adults

et al. 1995

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“…One pateint had a papillary carcinoma. The incidence of nodular thyroid abnormalities in MD appears to be increased as most studies suggest an incidence of between 2 and 5% in the general population (Vander et al, 1954(Vander et al, , 1968Sokal, 1959;Matovinovic et al, 1965, Pincus et al, 1967Tunbridge et al, 1977;Baldwin & Rowett, 1978). Postmortem studies have shown abnormal thyroid glands in MD patients with atrophic changes, cellular infiltrates or increased colloid formation being reported by Berthold (1958) in eleven out of thirty patients.…”

Section: Discussionmentioning

confidence: 98%

Thyroid Abnormalities in Patients With Myotonic Dystrophy

Steinbeck¹,

Carter²

1982

Clinical Endocrinology

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Myotonic dystrophy (MD) is a systemic genetic disorder predominantly affecting musculature. Although endocrine disturbances have been described, data relating to thyroid gland involvement are sparse and conflicting. To further investigate this aspect, twenty MD patients and twenty age-and sex-matched controls were studied. All were clinically euthyroid and there were no significant differences between circulating levels (mean +/- SD) of T4 (101 . 5 +/- 28.2 v. 103 . 8 +/- 27 . 7 nmol/l), T3 (1 . 86 +/- 0 . 57 v. 2 . 15 +/- 0 . 47 nmol/l), rT3 (0 . 39 +/- 0 . 14 v. 0 . 42 +/- 0 . 09) nmol/l) or TSH (2 . 6 +/- 0 . 5 v. 2 . 4 +/- 0 . 8 mu/l) or between T3 resin uptakes (97 +/- 8 v. 98 +/- 11%). TSH responses following TRH stimulation were significantly less in the MD patients (323 +/- 141 v. 529 +/- 240%; P less than 0.0025). The mean maximum TSH levels achieved were 6 . 7 +/- 3 . 6 mu/l (MD) and 17 . 1 +/- 7 . 2 mu/l (controls); P less than 0.005. Two patients had multinodular goitres (MNG) and one a single thyroid nodule. Thyroid scans were normal except for patchy uptake in the two MNG patients. There was no abnormal incidence of circulating thyroid microsomal or thyroglobulin antibodies, and thyrotrophin binding inhibitory immunoglobulin levels were normal in four patients. It is concluded that in MD: 1 palpable thyroid gland abnormalities occur with increased frequency, 15% (three/twenty) in the present study and 20% (twenty/102 case reports) from a review of the literature; 2 TSH responses to TRH are significantly reduced; 3 circulating thyroid hormone levels are usually normal.

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Incidence of Thyroid Disorders in Connecticut

Cited by 36 publications

References 5 publications

Comparing thyroid ultrasonography to thyroid function in long‐term survivors of childhood lymphoma

Comparing thyroid ultrasonography to thyroid function in long‐term survivors of childhood lymphoma

Clinical Presentation of Spontaneous Primary Hypothyroidism in Adults

Thyroid Abnormalities in Patients With Myotonic Dystrophy

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