Incidence of traumatic spinal cord injury worldwide: A systematic review, data integration, and update

Jazayeri, Seyed Behnam; Maroufi, Seyed Farzad; Mohammadi, Esmaeil; Ohadi, Mohammad Amin Dabbagh; Hagen, Ellen-Merete; Chalangari, Maryam; Jazayeri, Seyed Behzad; Safdarian, Mahdi; Zadegan, Shayan Abdollah; Ghodsi, Zahra; Rahimi-Movaghar, Vafa

doi:10.1016/j.wnsx.2023.100171

Cited by 32 publications

(13 citation statements)

References 65 publications

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“… 34 Moreover, most of the available literature evaluated the epidemiological aspects of SCI in high-income countries. In 2023, Jazayeri and colleagues updated their search strategy and found 58 new reports for 31 countries, 38 implying that data compilation efforts are increasing globally. However, there is still a huge gap to fill to draw a more accurate global map for SCI incidence and prevalence, especially for LMICs.…”

Section: Discussionmentioning

confidence: 99%

Global, regional, and national burden of spinal cord injury, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Safdarian,

Trinka,

Rahimi-Movaghar

et al. 2023

The Lancet Neurology

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Section: Discussionmentioning

confidence: 99%

Global, regional, and national burden of spinal cord injury, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Safdarian,

Trinka,

Rahimi-Movaghar

et al. 2023

The Lancet Neurology

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“…The annual incidence of SCI worldwide is estimated at 10.4 to 83.0 cases per 1 million people [3,4]. The study showed that the incidence from 45 cases per million population in 2009 to 66 cases per million population in 2018 [5].…”

Section: Introductionmentioning

confidence: 95%

Tanshinone IIA Regulate Inflammatory Response and Promote Functional Recovery in Rats with Spinal Cord Injury

Lin,

Chen

2024

CMR

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Purpose: The treatment of spinal cord injury (SCI) is a clinical challenge. The study attempted to investigate the effects of Tanshinone IIA on SCI in rats. Methods: The SCI model of rat was established based on Allen's animal model. The rats were randomly divided into four groups as follows: Control, Sham, SCI model, SCI + Tanshinone IIA. Rats were administrated with Tanshinone IIA (30mg/kg) respectively daily within one week after establishment of SCI model. Scores of Basso, Beattie, Bresnahan (BBB) was evaluated on the 1st, 3rd, 5th and 7th day after operation. Rats were sacrificed seven days after SCI, and the pathological injury of spinal cord tissue was assessed by HE staining. The levels of inflammatory cytokines (IL-1β and TNF-α) were detected by ELISA. Results: On the 7th day after operation, the BBB score of SCI + Tanshinone IIA group was significantly better than that of SCI group (P<0.01). Compared with SCI group, the pathological changes, neuronal pyknosis, hemorrhage, inflammatory infiltration, and white matter cavity formation in SCI + Tanshinone IIA group were reduced. Compared with SCI group, the level of IL-1 β and TNF-α in SCI+ Tanshinone IIA group were significantly lower (P<0.01). Conclusion: Tanshinone IIA can significantly improve motor function inhibit inflammation and repair spinal cord function after SCI.

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“…Traumatic spinal cord injury (TSCI), such as tra c accidents, falls, and sports injuries, is common, while nontraumatic SCI (NTSCI) is primarily attributed to conditions such as myelitis, intraspinal tumors, and vascular malformations. The incidence of TSCI ranges from 3.3 to 195.4 cases per million, with slight and steady increases for both males and females [2][3][4]. Globally, there were 0.9 million incident cases, 20.6 million individuals were living with SCI, 6.2 million years lived with disability (YLD) were diagnosed with total SCI in 2019 [1], and the age-standardized incidence rate and age-standardized YLD rate decreased [5].…”

Section: Introductionmentioning

confidence: 99%

A National Cross-Sectional Survey on Community Spinal Cord Injury Patient Profiles, Health-Related Quality of Life and Support Services in China: Implications for Healthcare and Rehabilitation

pan,

Ding,

Zhu

et al. 2024

Preprint

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Background Spinal cord injury (SCI) is defined as a damage to the spinal cord that causes serious and permanent changes in function; it has a high incidence, high cost, high disability rate and adult onset and has become a global health priority. National epidemiological data on SCI in China are available for only a limited number of provinces and are mostly outdated. Therefore, the aim of this study was to provide a national cross-sectional investigation of epidemiological data on individuals with SCI in China. Methods A total of 3055 SCI patients aged 8–78 years were included in this cross-sectional study, which was conducted between May 2023 and September 2023. We collected detailed information, including general demographic characteristics, employment status, etiology, years lived with disability (YLD), family structure, caregiving status, income, available health insurance, paralysis type, and health-related quality of life (HRQoL). Descriptive statistics and Kolmogorov‒Smirnov analyses were also conducted to analyze demographic and injury features. The t test and Mann‒Whitney test were employed to evaluate differences across distinct groups. Logistic regression analysis was used to evaluate the associations between HRQoL and other factors. Results Overall, 88.89% of the survey respondents were aged 15 to 59 years. The male-to-female ratio was 2.36:1. The etiology of the disease varied: 45.36% of the quadriparesis cases were caused by car accidents, more than 1/3 (35.93%) of the paraplegia cases were caused by falls, and myelitis emerged as the leading cause of nontraumatic SCI. In terms of injury sites and paralysis type, 65.51% of the paraplegia patients had complete SCI, and 53.11% of the tetraplegia patients had incomplete SCI. Considering functional recovery, 9.58% of the patients reported improvement. A total of 50.28% of the respondents were unemployed. In addition, 75% of their income fell below both the national mean and median levels. Furthermore, the HRQoL was significantly lower in the SCI population than in the control group and was mainly affected by injury site, income and age (p < 0.05). Conclusions SCI patients in communities in China had low HRQoL and reemployment rates. Convenient and cost-effective community rehabilitation and vocational rehabilitation are conducive to promoting the reemployment of patients with SCI and reducing disease-related burdens, and national basic public medical services and sound healthcare systems are conducive to improving the HRQoL of individuals with SCI.

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Incidence of traumatic spinal cord injury worldwide: A systematic review, data integration, and update

Cited by 32 publications

References 65 publications

Global, regional, and national burden of spinal cord injury, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Global, regional, and national burden of spinal cord injury, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Tanshinone IIA Regulate Inflammatory Response and Promote Functional Recovery in Rats with Spinal Cord Injury

A National Cross-Sectional Survey on Community Spinal Cord Injury Patient Profiles, Health-Related Quality of Life and Support Services in China: Implications for Healthcare and Rehabilitation

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