Incidence of Venous Thromboembolism and Its Pharmacological Prophylaxis in Asian General Surgery Patients: A Systematic Review

Yeo, Danson; Junnarkar, Sameer P; Balasubramaniam, Sunder; Tan, Yen Pin; Low, Jee Keem; Woon, Winston; Pang, Tony

doi:10.1007/s00268-014-2763-0

Cited by 45 publications

(44 citation statements)

References 35 publications

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“…There have been studies to show that the incidence of DVT is relatively lower in Asians including Japanese as compared to their Western counterparts [21][22][23]. Medical prophylaxis for DVT after total knee arthroplasty or total hip arthroplasty has been routinely performed in our hospital according to the Japanese guideline [24].…”

Section: Reference a Modified Odds Ratio Bmentioning

confidence: 99%

Rapidly progressive cervical myelopathy had a high risk of developing deep venous thrombosis: a prospective observational study in 289 cases with degenerative cervical spine disease

et al. 2018

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Study design A prospective observational study. Objectives To determine the incidence of deep venous thrombosis (DVT) and to evaluate the risk factors for DVT development associated with degenerative cervical spine disease. Setting Hokkaido Spinal Cord Injury Center, Japan. Methods Between April 2008 and March 2015, patients with degenerative cervical spine disease, such as compressive myelopathy or radiculopathy, who underwent surgical treatment were prospectively assessed. Leg vein ultrasonography and D-dimer tests were performed preoperatively and at 4 days after surgery. All patients received treatment with intermittent pneumatic compression and elastic stockings for primary DVT prophylaxis. No anticoagulation medications were used for DVT prophylaxis. Results A total of 289 patients (203 males, 86 females; median age: 67 years (interquartile range, 58-76)) were included. Nine patients (3.1%) exhibited DVT during the perioperative period. All 9 cases were women who had distal DVT. The incidences of preoperative and postoperative DVT were 1.1% and 2.1%, respectively. The univariate analysis showed that statistically significant risk factors for perioperative DVT included female gender (P < 0.01), advanced age (P = 0.04), a low Japanese Orthopaedic Association score (P = 0.03), rapidly progressive myelopathy (P < 0.01), and inability to walk (P = 0.01). The multivariate analysis showed that rapidly progressive myelopathy (P = 0.04) was the most important risk factor. Conclusion Female gender and rapidly progressive myelopathy are high-risk factors that predict the development of DVT during the perioperative period of cervical spine surgery. This result indicates that screening and treatment for DVT are needed in such high-risk patients.

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Section: Reference a Modified Odds Ratio Bmentioning

confidence: 99%

Rapidly progressive cervical myelopathy had a high risk of developing deep venous thrombosis: a prospective observational study in 289 cases with degenerative cervical spine disease

et al. 2018

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“…The other patient developed IVC thrombosis after a right hepatectomy for colorectal liver metastases. VTE risk factor assessment based on Caprini Risk Score was calculated for all patients in the cohort study [4]. The majority of patients (82%) were classified as high risk (total Caprini Risk Score >5).…”

Section: Resultsmentioning

confidence: 99%

“…Unfortunately, no data exists in literature on the incidence of VTE in HPB surgery patients in Asian patients. The majority of Asian VTE general surgery studies were on either colorectal or gastric cancer surgery patients, with no study examining VTE risk in HPB patients exclusively [13].…”

Section: Discussionmentioning

confidence: 99%

“…These ranged from small hematomas and minor ooze to major intra-abdominal and intraluminal bleeding [17,18]. Interestingly though, studies which used LMWH in Asian patients invariably demonstrated a zero rate of symptomatic VTE [13]. However, it is estimated that the number needed to treat to prevent one symptomatic VTE and PE to be 70 and 140 respectively [13].…”

Section: Discussionmentioning

confidence: 99%

“…Recent systematic review suggest that the risk of VTE in Asian general surgery patients is low, even in the context of risk factors typically regarded as high risk [4]. The aim of this study was therefore to determine the incidence of clinically significant VTE events in patients undergoing major hepatobiliary and pancreatic (HPB) surgery in a tertiary institution.…”

mentioning

confidence: 99%

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The incidence of clinically significant venous thromboembolism in an Asian population after major hepatobiliary and pancreatic surgery

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Venous Thromboembolism Prophylaxis in High‐Risk General Surgery in Asia

Liew

Lee

2015

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Incidence of Venous Thromboembolism and Its Pharmacological Prophylaxis in Asian General Surgery Patients: A Systematic Review

Abstract: Data from this systematic review suggest that the risk of VTE in Asian general surgery patients is low, even in the context of risk factors typically regarded as high risk.

Cited by 45 publications

References 35 publications

Rapidly progressive cervical myelopathy had a high risk of developing deep venous thrombosis: a prospective observational study in 289 cases with degenerative cervical spine disease

Rapidly progressive cervical myelopathy had a high risk of developing deep venous thrombosis: a prospective observational study in 289 cases with degenerative cervical spine disease

The incidence of clinically significant venous thromboembolism in an Asian population after major hepatobiliary and pancreatic surgery

Venous Thromboembolism Prophylaxis in High‐Risk General Surgery in Asia

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