Incidence of venous thromboembolism in different ethnic groups: a regional direct comparison study

Abstract

Summary Background There are few studies that directly compare the variation in incidence of venous thromboembolism (VTE) according to ethnicity. Objective The aim of this study was to compare the rates of VTE, deep venous thrombosis (DVT) and pulmonary embolism (PE) among different ethnic groups. Method The cases diagnosed with VTE, DVT and PE for a period between March 2004 and June 2009 were identified through the hospital‐based database system. The 2006 New Zealand Census data were used to calculate the rate of diagnosis. Results The observed annual incidence of VTE during this period was 81.6 per 100 000 population. The relative risks of VTE when comparing European subjects with Maori, Pacific Island and Asian subjects after age standardization were 1.98 (95% confidence interval [CI], 1.63–2.41), 3.22 (95% CI, 2.60–3.99) and 4.02 (95% CI, 3.34–4.84), respectively. Relative risks of DVT after age standardization when comparing European subjects with Maori, Pacific Island and Asian subjects, were 2.14 (95% CI, 1.72–2.66), 3.20 (95% CI, 2.46–4.17) and 4.75 (95% CI, 3.80–5.94), respectively. Indirect age standardization was used for comparison of the diagnosis of PE. The ratio between the calculated expected number of cases and the actual number of cases was 1.32 (95% CI, 0.89–1.75) for Maori subjects, 2.96 (95% CI, 1.89–4.03) for Pacific Islanders and 3.89 (95% CI, 3.00–4.78) for Asians. Conclusion Europeans have a significantly higher incidence of VTE compared with Maori, Pacific Island and Asian populations.

The incidence of clinically significant venous thromboembolism in an Asian population after major hepatobiliary and pancreatic surgery

“…However, there are evidences to suggest that it does occur as previously reported by Chew et al and Satoh et al mainly focused on cancer-related VTE among Taiwanese and Japanese, although at a lower rate than in the Caucasian population [7][8][9]. This is consistent with literature that common genetic polymorphisms, such as Factor V Leiden and prothrombin G20210A, and environmental risk factors, such as obesity, may account for increased risk in European population [10].…”

Incidence, Characteristics and Management of Venous Thromboembolism in Japan During 2011

“…7-9 The relative risk of VTE in European and Asian patients after age standardization is 4.02. 10 The present study found that 16,096 and 24,538 individuals in Japan were diagnosed with new PE and DVT, respectively, during 2011, which represented overall annual incidences of 12.6 and 19.2 per 100,000, respectively. Table 5 shows the changes in the annual numbers of patients diagnosed as PE in Japan determined from previous surveys.…”

Ankylosing spondylitis and risk of venous thromboembolism: A systematic review and meta-analysis

“…[123] Deep venous thrombosis (DVT) and pulmonary embolism (PE) are its two major subtypes. VTE is associated with a long-term morbidity and mortality with an estimated cumulative incidence of recurrence of 10% at 1 year and 30% at 5 years after the withdrawal of anticoagulation therapy.…”