Incidence of vestibular schwannomas in the United States

Kshettry, Varun R.; Hsieh, Jason K.; Ostrom, Quinn T.; Kruchko, Carol; Barnholtz‐Sloan, Jill S.

doi:10.1007/s11060-015-1827-9

Cited by 117 publications

(104 citation statements)

References 27 publications

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“…Schwannomas, especially vestibular schwannomas, can give rise to hydrocephalus, which can be both obstructive and communicating in nature. 21 In their epidemiologic study of vestibular schwannomas in a US population, Kshettry et al 15 found that the peak overall incidence was between 65 and 74 years of age, with a higher incidence in Caucasian than in African American patients. In this study, however, the peak incidence of hydrocephalus in these patients was in the 3rd and 6th decades.…”

Section: Tumorsmentioning

confidence: 99%

Epidemiology of adult-onset hydrocephalus: institutional experience with 2001 patients

Bir

Patra

Maiti

et al. 2016

FOC

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OBJECTIVE Adult-onset hydrocephalus is not commonly discussed in the literature, especially regarding its demographic distribution. In contrast to pediatric hydrocephalus, which is related to a primary CSF pathway defect, its development in adults is often secondary to other pathologies. In this study, the authors investigated the epidemiology of adult-onset hydrocephalus as it pertains to different etiologies and in reference to age, sex, and race distributions. METHODS The authors retrospectively reviewed the clinical notes of 2001 patients with adult-onset hydrocephalus who presented to Louisiana State University Health Sciences Center within a 25-year span. Significant differences between the groups were analyzed by a chi-square test; p < 0.05 was considered significant. RESULTS The overall mean (± SEM) incidence of adult hydrocephalus in this population was 77 ± 30 per year, with a significant increase in incidence in the past decade (55 ± 3 [1990–2003] vs 102 ± 6 [2004–2015]; p < 0.0001). Hydrocephalus in a majority of the patients had a vascular etiology (45.5%) or was a result of a tumor (30.2%). The incidence of hydrocephalus in different age groups varied according to various pathologies. The incidence was significantly higher in males with normal-pressure hydrocephalus (p = 0.03) or head injury (p = 0.01) and higher in females with pseudotumor cerebri (p < 0.0001). In addition, the overall incidence of hydrocephalus was significantly higher in Caucasian patients (p = 0.0002) than in those of any other race. CONCLUSIONS Knowledge of the demographic variations in adult-onset hydrocephalus is helpful in achieving better risk stratification and better managing the disease in patients. For general applicability, these results should be validated in a large-scale meta-analysis based on a national population database.

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Section: Tumorsmentioning

confidence: 99%

Epidemiology of adult-onset hydrocephalus: institutional experience with 2001 patients

Bir

Patra

Maiti

et al. 2016

FOC

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“…Vestibular schwannomas (VSs) are rare benign tumors of the central nervous system, with about three‐thousand new diagnoses in the United States annually . Although there have been great advances in the diagnosis and treatment of VS in the past few decades, the ability to consistently preserve hearing remains elusive, leaving many patients with hearing deficits as a result of either their disease or treatment.…”

Section: Introductionmentioning

confidence: 99%

Trends in hearing rehabilitation use among vestibular schwannoma patients

et al. 2019

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Objective: Most patients with vestibular schwannoma (VS) have significant hearing loss in the affected ear as a result of either their tumor or treatment. There is a paucity of data on which hearing rehabilitation options, if any, are preferred by patients with VS. Our study analyzed the use of hearing rehabilitation devices among VS patients.Methods: Patients with unilateral VS treated at our institution from January 2008 to August 2018 were identified. Those with bilateral VS, profound hearing loss in the contralateral ear, neurofibromatosis type 2, or inadequate follow-up were excluded. Patients who met inclusion criteria were given two online questionnaires: an 8-item instrument that assesses use of hearing rehabilitation devices and the Abbreviated Profile of Hearing Aid Benefit.Results: Of 212 eligible patients, 61 completed both surveys. The majority (88%) were able to hear "poorly" or "not at all" in the affected ear, but less than one-third had ever used a hearing rehabilitation device. Most had used conventional hearing aids (30%) or contralateral routing of signal/bilateral contralateral routing of signal (30%), whereas only a handful had used bone-anchored hearing devices or cochlear implant. Patients who did not pursue hearing rehabilitation were either not bothered by their deficit or were unaware of their options. Most had good functionality despite their deficit.Conclusion: Whereas 88% of patients treated for VS had a significant hearing loss, the majority did not pursue hearing rehabilitation but maintained good functional performance. Many did not remember being counseled about hearing rehabilitation options, indicating that regular and repeated counseling may be needed to increase patient utilization of hearing rehabilitation after VS treatment.

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“…We do not have a national registry but the overall incidence of vestibular schwannoma has been reported as 1.09 per 100,000 population. 13 Unlike our clinical scenario, increasing availability and frequent use of magnetic resonance (MR) imaging have led to diagnosis of very small tumors worldwide, 8 with neurosurgeons successfully attempting hearing preservation.…”

mentioning

confidence: 99%

Facial Nerve Preservation and Surgical Outcomes of Retrosigmoid Approach to Large Vestibular Schwannoma- an Eight-year Single Institution Experience

Shrestha¹,

Kutu²,

Lohani³

et al. 2017

Nep J Neurosci

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Objective: To evaluate the result of microsurgical excision of vestibular schwannoma by retrosigmoid approach and to correlate the facial nerve outcome with the tumor size.Methods: Retrospective analysis of 84 patients with cerebello-pontine angle lesions (57 vestibular schwannomas) operated at National Institute of Neurological and Allied Sciences, Nepal, from Baisakh 2066 to Chaitra 2073 (eight years). Facial nerve outcomes as per the House and Brackmann grading at six months follow-up were recorded and correlated with tumor size.Result: The mean tumor size was 4.32 ± 1.23 cms and 48 (84.2%) of the patients had tumor size more than 3 cms. Patients presented late with papilloedema documented in 42.1% and preoperative ventriculoperitoneal shunting required in 31.57% patients. Of the patients whose facial nerve functions could be followed up, all patients with tumors < 3cm diameter had good House and Brackmann facial nerve outcome (grade I to III). Larger tumors had poorer facial nerve outcomes; however statistical significance could not be reached. (Fischer Exact test, p-value: 0.077). There were two mortalities (3.5%), one following cavity rebleed and one following malignant brain swelling.Conclusion: Retrosigmoid approach is a versatile surgical corridor to excise large vestibular schwannomas with minimal complications and larger tumors have poorer facial nerve outcomes. Nepal Journal of Neuroscience, Volume 14, Number 3, 2017, Page: 19-25

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Incidence of vestibular schwannomas in the United States

Cited by 117 publications

References 27 publications

Epidemiology of adult-onset hydrocephalus: institutional experience with 2001 patients

Epidemiology of adult-onset hydrocephalus: institutional experience with 2001 patients

Trends in hearing rehabilitation use among vestibular schwannoma patients

Facial Nerve Preservation and Surgical Outcomes of Retrosigmoid Approach to Large Vestibular Schwannoma- an Eight-year Single Institution Experience

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