Incidence of Yq Microdeletion among Chattishgarh Population and Cast based distribution

Abstract

Background: Millions of individuals in their reproductive years are affected by infertility on a global scale, potentially exerting a significant influence on their lives and family dynamics. The coexistence of abnormal seminogram and Yq microdeletion synergistically affects infertility. Therefore, the study was designed to determine the frequency of distribution of Yq microdeletion in abnormal semen parametric infertility cases. Methodology: Seventy-five cases of infertility and 78 controls with known fertility were enrolled for the cross-sectional study. In the collected blood sample, DNA was isolated and a polymerase chain reaction (PCR) mix for various markers was prepared. After running in a thermocycler, PCR products were analyzed by gel electrophoresis. Results: The distribution of deletion among different subtypes: azoospermic, severe oligozoospermic, oligozoospermic, and normozoospermic cases was 35%, 33%, 35%, and 33%, respectively. The most common deletion type in the Chhattisgarh population was azoospermia factor c. Caste-based distribution among the study group was quite uniform. Conclusion: Y chromosome microdeletion would be an essential test after seminogram in cases of male infertility, especially to prevent the transmission or inheritance of infertility to offspring. Due to the high frequency of microdeletions, it is a very useful test to identify male infertility in Chhattisgarh.