Incidence of Zinc Toxicity as a Complication of Phototherapy

Saravanan, S.

doi:10.18535/jmscr/v5i4.79

Cited by 3 publications

(7 citation statements)

References 10 publications

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“…There was a significant increase in the percentage of neonates with zinc levels > 200 mg/dL after phototherapy (before phototherapy 3 (4%) neonates, after phototherapy 10 (15%) neonates. This agrees with [14] who found that, Phototherapy was associated with a significant increase in the serum zinc level in neonates with severe hyperbilirubinemia (TSB >18 mg/dL) but not in those with mild moderate hyperbilirubinemia (TSB<18 mg/dL). In addition, phototherapy caused a significant increase in the rate of zinc with potentially toxic levels (zinc > 200) in only neonates with severe hyperbilirubinemia.…”

Section: Discussionsupporting

confidence: 92%

Serum Zinc Alteration in full term Neonate with Hyperbilirubinemia before and after Phototherapy

Dabour

Assar

Behiry

et al. 2020

Benha Journal of Applied Sciences

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Hyperbilirubinaemia is one of the commonest causes of admission to hospital in neonatal period. The final product of heme protein catabolism is an unconjugated bilirubin. One of the factors that affect the severity and incidence of jaundice is the level of serum zinc. This study aimed to evaluate serum zinc level in neonatal hyperbilirubinemia before and after phototherapyMethods:The study was conducted on two groups: Study group included 50 neonates hahyperbilirubinemia. Control group included 50 neonates. All groups were subjected to Full history, Full examination and Laboratory Investigations included:Serum zinc level before and (12-24hrs) after phototherapy. Total serum billirubin and direct.Results:patient group was significantly associated with higher TSB when compared to control group.Zinc level was significantly lower in cases when compared to control group. phototherapy in neonates with severe hyperbilirubinemia was associated with a significant increase in the serum zinc levels.all studied cases were stratified according to basal TSB level into moderate hyperbilirubinemia (TSB<18 mg/dL) and severe hyperbilirubinemia (TSB≥18 mg/dL). In both subgroups, zinc level increased significantly after phototherapy. Basal serum zinc level showed significant negative correlation with TSB. Receiver operating characteristic (ROC) curve of zinc level was conducted for discrimination between moderate and severe hyperbilirubinemia cases.Fair AUC was found (AUC = 0.760)at best cut of value of baseline zinc (=84.5ug/dl), sensitivity was 82.4%, specificity was 66.7%, Conclusion:Phototherapy by reducing the bilirubin level causes an increase in the serum zinc level .

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Section: Discussionsupporting

confidence: 92%

Serum Zinc Alteration in full term Neonate with Hyperbilirubinemia before and after Phototherapy

Dabour

Assar

Behiry

et al. 2020

Benha Journal of Applied Sciences

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“…About our primary outcomes, the present study showed that serum zinc level increased significantly after phototherapy in our study group (75.45 ± 14.94; p-value < 0.001). This is in concordance with Saravanan and Raghuram (15) who performed a prospective cohort study to estimate serum zinc level alterations before and after phototherapy, in jaundiced newborns. Their results showed that phototherapy was associated with a significant increase in serum zinc level in neonates with (TSB >18 mg/dL) but not in those with (TSB<18 mg/dL).…”

Section: Discussionsupporting

confidence: 90%

“…In addition, our analysis showed that the duration of phototherapy was 2.4 ± 0.5 days, which is similar to Mosayebi et al (14) and Saravanan and Raghuram (15) where the duration was 2.4 ± 0.6 days in both studies.…”

Section: Discussionsupporting

confidence: 89%

“…In addition, the majority of patients were males (53%) and 84% of the study group were delivered via cesarean section. Saravanan and Raghuram (15) in a study about zinc toxicity as a complication of phototherapy found that 50% of the study group were males and 66% of the study group were born by cesarean section. Najib et al (16) performed a cross-sectional study to assess the characteristics of all infants less than 28 days referred due to severe indirect hyperbilirubinemia.…”

Section: Discussionmentioning

confidence: 96%

“…Also In our study, we found that there was a significant negative correlation between serum bilirubin and serum zinc level after phototherapy (r = -0.218, P = 0.029). Saravanan and Raghuram (15) reported that there was significant negative correlation between serum bilirubin and serum zinc levels before phototherapy (r= -0.31, P= 0.01) and after phototherapy (r= -0.4, P=0.01).…”

Section: Discussionmentioning

confidence: 99%

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Effect of Phototherapy on Serum Zinc Level in Neonatal Jaundice

Baiomi

Hassan

Besher

et al. 2020

The Egyptian Journal of Hospital Medicine

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Background: Zinc salts can reduce phototherapy duration by precipitating unconjugated bilirubin in the intestine however, zinc toxicity is an issue that must be considered. Theoretically, bilirubin reduction by phototherapy may increase serum zinc levels, making additional zinc supplementation, which cause zinc toxicity. Objectives: To evaluate serum zinc level alterations before and after phototherapy in hyperbilirubinemic newborns. Materials and Methods: A prospective cross sectional case-control study was performed at Neonatal Intensive Care Unit (NICU),

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Zinc level alternation after phototherapy in neonates with hyperbilirubinemia

et al. 2023

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Introduction: One of the old treatment methods for unconjugated hyperbilirubinemia in neonates is blood exchange transfusion, which is expensive, possibly high-risk, and time-consuming. Today phototherapy as a novel method can be a good alternative. Objectives: This study aimed to evaluate the zinc level alternation after phototherapy in neonates with hyperbilirubinemia. Patients and Methods: A descriptive-analytical study was conducted on 85 infants with hyperbilirubinemia who underwent phototherapy referred to the pediatric hospital in Bandar- Abbas, Iran from 2017 to 2018. Healthy infants over two days with idiopathic jaundice with a gestational age greater than 34 weeks and only breast-feed were enrolled. Serum zinc levels were measured before and after phototherapy, and their changes were evaluated. Results: Out of 85 neonates, 42 (49.4%) were male and 43 (50.6%) were female with a mean gestational age of 37.83 ± 0.58 weeks and admission age of 4.15 ± 1.70 days. Zinc level before phototherapy was 84.98 ± 52.06 (μg/dL) and after phototherapy was 234.41 ± 280.98. The difference between serum zinc levels before and after the phototherapy was significant therefore, the zinc level significantly increased after the phototherapy. Conclusion: Results showed that phototherapy increases serum zinc levels, which can cause zinc toxicity. It is wise to measure serum zinc levels before and during phototherapy and seek the appropriate medical care.

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Incidence of Zinc Toxicity as a Complication of Phototherapy

Cited by 3 publications

References 10 publications

Serum Zinc Alteration in full term Neonate with Hyperbilirubinemia before and after Phototherapy

Serum Zinc Alteration in full term Neonate with Hyperbilirubinemia before and after Phototherapy

Effect of Phototherapy on Serum Zinc Level in Neonatal Jaundice

Zinc level alternation after phototherapy in neonates with hyperbilirubinemia

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