2020
DOI: 10.1155/2020/8249497
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Incidence, Predictors, and Outcome of Paravalvular Leak after Transcatheter Aortic Valve Implantation

Abstract: Background. Paravalvular leak (PVL) is common after transcatheter aortic valve implantation (TAVI) and has been linked with worse survival. This study aimed to investigate the determinants and outcome of PVL after TAVI and determine the role of aortic valve calcification (AVC) distribution in predicting PVL. Methods and Results. This was a retrospective cohort study of 270 consecutive patients who underwent TAVI. Determinants and outcomes of ≥mild PVL were assessed. Matching rates of PVL jet with AVC distribut… Show more

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Cited by 25 publications
(21 citation statements)
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“…13,14 Anatomy tailored THV selection in the presence of a short MS may help mitigate need for PPI after TAVR but should also take into consideration risks for THV underexpansion, prosthesis patient mismatch and paravalvular leaks that may impact clinical outcome after TAVR. [15][16][17]…”
Section: Discussionmentioning
confidence: 99%
“…13,14 Anatomy tailored THV selection in the presence of a short MS may help mitigate need for PPI after TAVR but should also take into consideration risks for THV underexpansion, prosthesis patient mismatch and paravalvular leaks that may impact clinical outcome after TAVR. [15][16][17]…”
Section: Discussionmentioning
confidence: 99%
“…Several risk factors for the need of PPM have been identified, 10 such as preexisting conduction disease, calcification of the aortic or mitral valve annulus, valve implantation depth, balloon post‐dilatation, and using a self‐expandable valve. More than mild PVL has been related mainly to the same predictive factors 11 . In our population, a self‐expandable valve was used in 62% of the matched TAVI patients, which might partially explain why our PPM and PVL rates were in line with the Evolut Low Risk and the NOTION trials, which used a self‐expandable valve for all procedures.…”
Section: Discussionmentioning
confidence: 64%
“…This could be explained by the fact that the mean implantation depth in our study was higher and more following the manufactures recommendation than in the above study (4.3 ± 3.0 mm vs. 6.2 ± 2.9 mm). According to previous publications, a higher calcification grade of the device landing zone is associated with a more pronounced PVL [ 16 , 17 ].…”
Section: Discussionmentioning
confidence: 95%