Incidence, prevalence, and global burden of schizophrenia - data, with critical appraisal, from the Global Burden of Disease (GBD) 2019

Solmi, Marco; Seitidis, Georgios; Mavridis, Dimitris; Correll, Christoph U.; Dragioti, Elena; Guimond, Synthia; Tuominen, Lauri; Dargél, Aroldo A.; Carvalho, André F.; Fornaro, Michele; Maes, Michaël; Monaco, Francesco; Song, Minjin; Smıth, Lee; Cortese, Samuele

doi:10.1038/s41380-023-02138-4

Cited by 86 publications

(17 citation statements)

References 43 publications

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“…Schizophrenia is a severe mental disorder characterized by positive symptoms (delusions, hallucinations, and disorganized thinking) and negative symptoms (aphasia, social withdrawal, and emotional slowness) . According to the Global Burden of Disease (GBD) report, the global number, prevalence, and disability-adjusted life-years (DAYL) of schizophrenia have increased by 65%, 15%, and 65% from 1990 to 2019, respectively . In China, the prevalence of schizophrenia reaches 3.87‰ [95% confidence interval (CI): 3.44‰, 4.30‰], resulting in 3.57 million person-years of DAYL, which accounts for 23.63% of the total global burden .…”

Section: Introductionmentioning

confidence: 99%

Effects of PM_2.5 and Its Components on Disease Severity in Patients with Schizophrenia and the Mediating Role of Thyroid Hormones

Liu,

Song,

et al. 2024

Environ. Health

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Studies have indicated the different effects of PM 2.5 components on human health. However, specific components that influence the severity of disease in schizophrenia patients and their underlying mechanisms remain unclear. Therefore, a repeated measures study for schizophrenia was constructed based on Anhui Mental Health Center. We collected information, including demographics and thyroid hormones (TH) levels, on repeat admissions of schizophrenia patients during 2017−2020, assessing their illness severity by positive and negative symptom scales (PANSS). Concentrations from the nearest component monitoring station in the 3 months before admission were assigned as the participant's exposure level. We assessed the effects of PM 2.5 components individually and in combination on schizophrenia and explored the mediating role of THs. Results indicated that benzo[a]pyrene, sulfate, nitrate, chloride, ammonia, cadmium, chromium, lead, selenium, and thallium exposure were associated with increased PANSS scores, with more significant results observed in males. Mixed exposure to PM 2.5 components was found to be associated with increased PANSS scores and decreased free triiodothyronine (FT3). Mediation analysis suggested that the reduction in FT3 might mediate the association between the PM 2.5 components and PANSS scores. The findings emphasize the impacts of PM 2.5 components on schizophrenia and the potential value of focusing on changes in THs.

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Section: Introductionmentioning

confidence: 99%

Effects of PM_2.5 and Its Components on Disease Severity in Patients with Schizophrenia and the Mediating Role of Thyroid Hormones

Liu,

Song,

et al. 2024

Environ. Health

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“…Mental disorders constitute a considerable and increasing burden on global health, both from an epidemiological and economic context [ 1 ]; according to the Global Burden of Disease Study (GBD) 2019 estimates, they account for over >400 million disability-adjusted life years (DALYs; 16% of the global burden), and ~USD 5 trillion of overall economic costs [ 2 ]. Mental disorders include depressive, bipolar and anxiety disorders; substance abuse disorders; eating disorders; schizophrenia (SCZ); and self-harm, among others, all of which are often associated with poor quality of life (QoL) [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Oral Health Status and Factors Related to Oral Health in Patients with Schizophrenia: A Matched Case-Control Observational Study

Aghasizadeh Sherbaf,

Kaposvári,

Nagy

et al. 2024

JCM

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Background: Schizophrenia (SCZ) patients have disproportionately poor oral health outcomes owing to a multidimensional set of factors, such as pathophysiology of the disease, drug-related adverse effects and lower utilization rate of dental healthcare services. The aim of the present observational study was to compare the indicators of dental and periodontal health in patients with SCZ to those of nonaffected healthy controls; furthermore, the influence of various anamnestic factors and lifestyle habits on oral health status were also assessed. Methods: A total of 50 SCZ patients—in remission—receiving treatment at the Department of Psychiatry, University of Szeged, were compared with 50 age- and gender-matched healthy controls attending the Faculty of Dentistry, University of Szeged. Participants’ dental (decayed, missing and filled surfaces [DMF-S] and decayed, missing and filled teeth [DMF-T]) and periodontal (plaque index [%], bleeding on probing [BOP%], pocket depth [PD] and attachment loss [AL]) status was measured according to the World Health Organization (WHO) criteria. Results: In total, 74.0%, 80.0% and 78.0% of SCZ patients received second-generation antipsychotics, benzodiazepines and mood stabilizers, respectively. Patients with SCZ had significantly higher DMFs (81.30 ± 40.16 vs. 61.64 ± 40.56; p = 0.010), D (8.18 ± 7.73 vs. 4.18 ± 4.22; p < 0.001) and DMF-T (18.20 ± 8.36 vs. 14.42 ± 8.21; p = 0.024) scores but significantly lower F (1.84 ± 0.29 vs. 4.62 ± 3.98; p < 0.001) scores compared to the controls; male subjects had significantly lower DMFs (74.52 ± 39.72 vs. 90.67 ± 39.1; p = 0.020) and DMF-T (16.52 ± 8.12 vs. 20.52 ± 8.32; p = 0.031) scores. Additionally, SCZ patients had significantly higher plaque indices (56.96 ± 23.19 vs. 27.44 ± 17.53; p < 0.001), BOP% (58.96 ± 22.89 vs. 23.56 ± 17.53; p < 0.001), PD (2.84 ± 0.67 vs. 2.19 ± 0.49; p = 0.024) and AL (3.39 ± 1.72 vs. 2.49 ± 0.76; p < 0.001) values compared to controls. Smoking > 10 cigarettes/day was associated with worse dental and periodontal indices, while consuming ≥ 4 units/week of alcohol was associated with worse periodontal indices, respectively (p < 0.05 in all cases). In contrast, coffee consumption rates and vitamin supplementation status had no significant effect on oral health status indicators. Conclusions: Our study highlights the overall poor oral health status of individuals affected by SCZ and the need for targeted preventive interventions.

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“…SZ is a brain dysfunction that can stimulate cognitive, emotional, mental, and behavioral disorders, which lead to problems in the patient's social life, work performance, self-interest, and usually causes comorbid diseases [ 2 ]. About 1∼1.5 % of the world population with different ethnicities is affected by SZ, which accounts for around 20 million people around the world [ 3 ]. Schizophrenic patients generally suffer from various clinical manifestations that are classified into positive, negative, and cognitive.…”

Section: Introductionmentioning

confidence: 99%

Plasma miRNAs as potential biomarkers for schizophrenia in a Jordanian cohort

Shboul,

Bani Domi,

Abu Zahra

et al. 2024

Non-coding RNA Research

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Incidence, prevalence, and global burden of schizophrenia - data, with critical appraisal, from the Global Burden of Disease (GBD) 2019

Cited by 86 publications

References 43 publications

Effects of PM_2.5 and Its Components on Disease Severity in Patients with Schizophrenia and the Mediating Role of Thyroid Hormones

Effects of PM_2.5 and Its Components on Disease Severity in Patients with Schizophrenia and the Mediating Role of Thyroid Hormones

Oral Health Status and Factors Related to Oral Health in Patients with Schizophrenia: A Matched Case-Control Observational Study

Plasma miRNAs as potential biomarkers for schizophrenia in a Jordanian cohort

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Incidence, prevalence, and global burden of schizophrenia - data, with critical appraisal, from the Global Burden of Disease (GBD) 2019

Cited by 86 publications

References 43 publications

Effects of PM2.5 and Its Components on Disease Severity in Patients with Schizophrenia and the Mediating Role of Thyroid Hormones

Effects of PM2.5 and Its Components on Disease Severity in Patients with Schizophrenia and the Mediating Role of Thyroid Hormones

Oral Health Status and Factors Related to Oral Health in Patients with Schizophrenia: A Matched Case-Control Observational Study

Plasma miRNAs as potential biomarkers for schizophrenia in a Jordanian cohort

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Product

Resources

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Effects of PM_2.5 and Its Components on Disease Severity in Patients with Schizophrenia and the Mediating Role of Thyroid Hormones

Effects of PM_2.5 and Its Components on Disease Severity in Patients with Schizophrenia and the Mediating Role of Thyroid Hormones