Incidence, prevalence, and survival trends for neuroendocrine neoplasms in Victoria, Australia, from 1982 to 2019: Based on site, grade, and region

Michael, M; Thursfield, Vicky; Marvelde, Luc te; Kong, Grace; Hicks, Rodney J.

doi:10.1111/ajco.13671

Cited by 5 publications

(3 citation statements)

References 44 publications

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“…Consistent with other countries or regions, [ 4 , 23 , 35 ] the incidence of NENs increased in China and the USA over the past 18 years, with even a more rapid increase in China. The most likely reason underlying this increase is the improvements and increased implementation in diagnostic tests, particularly endoscopy, computed tomography, and magnetic resonance imaging, which resulted in the detection of asymptomatic and early stage NENs.…”

Section: Discussionsupporting

confidence: 78%

“…A high proportion of NENs in the small intestine was observed in Western countries. [23][24][25] A previous study proposed that the low detection rate of small intestinal NENs would be responsible for the low percentage of small intestinal NENs in China. [9] However, a low proportion of small intestinal NENs is presented not only in the Chinese population, [10] but also in Asian/ Pacific Islanders of America.…”

Section: Discussionmentioning

confidence: 99%

“…The distribution of NENs varied among different countries or regions [Supplementary Figure 1, http://links.lww.com/CM9/ B492]. [23][24][25][26] In China, pancreas (33.5%), stomach (19.7%), and lung (15.2%) were the predominant primary sites of NENs, while in the USA, pulmonary (19.8%), small intestinal (16.6%), and colonic (15.9%) NENs tend to be the most prevalent. In Australia, Norway, and Canada, the most common site was the small intestine.…”

Section: Discussionmentioning

confidence: 99%

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Incidence and survival of neuroendocrine neoplasms in China with comparison to the United States

Zheng

Zhao

et al. 2023

Chinese Medical Journal

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Background: Neuroendocrine neoplasms (NENs) are rare tumors characterized by variable biology and delayed diagnosis. However, the nationwide epidemiology of NENs has never been reported in China. We aimed to estimate the incidence and survival statistics of NENs in China, in comparison to those in the United States during the same period. Methods: Based on the data from 246 population-based cancer registries covering 272.5 million people of China, we calculated age-specific incidence on NENs in 2017 and multiplied by corresponding national population to estimate the nationwide incidence in China. The data of 22 population-based cancer registries were used to estimate the trends of NENs incidence from 2000 to 2017 through the Joinpoint regression model. We used the cohort approach to analyze the 5-year age-standardized relative survival by sex, age group, and urban-rural area between 2008 and 2013, based on data from 176 high-quality cancer registries. We used data from the Surveillance, Epidemiology, and End Results (SEER) 18 program to estimate the comparable incidence and survival of NENs in the United States. Results: The overall age-standardized rate (ASR) of NENs incidence was lower in China (1.14 per 100,000) than in the United States (6.26 per 100,000). The most common primary sites were lungs, pancreas, stomach, and rectum in China. The ASRs of NENs incidence increased by 9.8% and 3.6% per year in China and the United States, respectively. The overall 5-year relative survival in China (36.2%) was lower than in the United States (63.9%). The 5-year relative survival was higher for female patients than male patients, and was higher in urban areas than in rural areas. Conclusions: The disparities in burden of NENs persist across sex, area, age group, and site in China and the United States. These findings may provide a scientific basis on prevention and control of NENs in the two countries.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Incidence and survival of neuroendocrine neoplasms in China with comparison to the United States

Zheng

Zhao

et al. 2023

Chinese Medical Journal

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Integrating Functional Imaging and Molecular Profiling for Optimal Treatment Selection in Neuroendocrine Neoplasms (NEN)

et al. 2023

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Purpose of Review Gastroenteropancreatic NEN (GEP-NEN) are group of malignancies with significant clinical, anatomical and molecular heterogeneity. High-grade GEP-NEN in particular present unique management challenges. Recent Findings In the current era, multidisciplinary management with access to a combination of functional imaging and targeted molecular profiling can provide important disease characterisation, guide individualised management and improve patient outcome. Multiple treatment options are now available, and combination and novel therapies are being explored in clinical trials. Summary Precision medicine is highly relevant for a heterogenous disease like NEN. The integration of dual-tracer functional PET/CT imaging, molecular histopathology and genomic data has the potential to be used to gain a more comprehensive understanding of an individual patient’s disease biology for precision diagnosis, prognostication and optimal treatment allocation.

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Nutritional aspects in neuroendocrine neoplasms. bridging the gap between dietary interventions and cancer care strategies: a scoping review

Massironi,

Panzuto,

Zilli

et al. 2024

J Endocrinol Invest

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Purpose Neuroendocrine neoplasms (NENs) represent heterogeneous tumors arising from neuroendocrine cells in different organs. Despite growing interest in the nutritional aspects of NEN management, research in this area is limited. Aim of this review is to summarize the current state of knowledge, highlight research gaps, and underscore the significance of nutrition in the comprehensive care of NEN patients. Methods We conducted an extensive bibliographic search focusing on studies (including retrospective and prospective studies, systematic reviews, case series, and guidelines) exploring the relationship between nutritional assessments, dietary interventions, micronutrient deficiencies, and their impact on NEN outcomes. Results Significant gaps exist in current research, particularly in understanding the specific nutritional needs of NEN patients and how tailored nutritional interventions can improve clinical outcomes. Evidence suggests that a high-fat Western diet may promote the growth of NEN, while a Mediterranean diet may help lower insulin levels and strengthen the immune system, potentially preventing tumor development. The ketogenic diet and intermittent fasting may also have positive impacts. Addressing common micronutrient deficiencies, such as vitamin D and niacin, is crucial to mitigate disease progression. There’s a crucial need for future studies to include a comprehensive nutritional assessment incorporating patient-reported outcomes, to fully capture the impact of nutritional strategies. Conclusion Nutritional management, an important but under-researched facet of NEN treatment, significantly improves patients’ quality of life and survival. Integrating nutrition into personalized cancer care is essential, highlighting the role of nutritional strategies in optimizing patient outcomes.

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Incidence, prevalence, and survival trends for neuroendocrine neoplasms in Victoria, Australia, from 1982 to 2019: Based on site, grade, and region

Cited by 5 publications

References 44 publications

Incidence and survival of neuroendocrine neoplasms in China with comparison to the United States

Incidence and survival of neuroendocrine neoplasms in China with comparison to the United States

Integrating Functional Imaging and Molecular Profiling for Optimal Treatment Selection in Neuroendocrine Neoplasms (NEN)

Nutritional aspects in neuroendocrine neoplasms. bridging the gap between dietary interventions and cancer care strategies: a scoping review

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