Incidence, progression and sequence of development of radiographic knee osteoarthritis in a symptomatic population

Duncan, Rachel; Peat, George; Thomas, Elaine; Hay, Elaine M; Croft, Peter

doi:10.1136/ard.2011.151050

Cited by 112 publications

(112 citation statements)

References 30 publications

Supporting

Mentioning

106

Contrasting

Order By: Relevance

“…Furthermore, it remains unclear what the acceptability of proprioceptive exercises would be based on those with greater severity of knee OA and associated pain, and older people with greater co-morbidities. Further study to assess this may be warranted given that knee OA is a chronic longer-term condition that therefore affects predominantly older individuals [7].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effectiveness of proprioceptive-based exercise for osteoarthritis of the knee: a systematic review and meta-analysis

2012

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

“…OA is the most common form of arthritis, with osteoarthritis of the knee being a leading cause of functional impairment in the elderly [7]. OA is predicted to be the fourth largest cause of disability by 2020 [8].…”

Section: Introductionmentioning

confidence: 99%

The effectiveness of proprioceptive-based exercise for osteoarthritis of the knee: a systematic review and meta-analysis

2012

View full text Add to dashboard Cite

“…Previous studies found that early signal inhomogeneities and morphologic lesions in the natural history of knee OA frequently occur at the patella, where the cartilage is thickest and therefore may be most vulnerable and sensitive to early degradation 8 47 52–54. Duncan et al 55 studied early radiographic findings in the patellofemoral joint and proposed that the onset of knee OA follows a common sequence initiating at the patellofemoral joint. Our results lend support to the hypothesis that early biochemical changes in the patella cartilage may precede TFOA.…”

Section: Discussionmentioning

confidence: 99%

Early T2 changes predict onset of radiographic knee osteoarthritis: data from the osteoarthritis initiative

et al. 2014

View full text Add to dashboard Cite

Objective To evaluate whether T2 relaxation time measurements obtained at 3 Tesla Magnetic Resonance Imaging (MRI) predict the onset of radiographic knee osteoarthritis (OA). Methods and Materials We performed a nested case-control study of incident radiographic knee OA in the Osteoarthritis Initiative (OAI) cohort. Cases were 50 knees with baseline KL grade of 0 that developed KL grade of 2 or more over a 4-year period. Controls were 80 knees with KL grade of 0 after four years of follow-up. Baseline T2 relaxation time measurements and laminar analysis of T2 in deep and superficial layers were performed in all knee compartments. The association of T2 values with incident OA was assessed with logistic regression and differences in T2 values by case-control status with linear regression, adjusting for age, sex, body mass index (BMI) and other covariates. Results Baseline T2 values in all compartments except the medial tibia were significantly higher in knees that developed OA compared to controls, and were particularly elevated in the superficial cartilage layers in all compartments. There was an increased likelihood of incident knee OA associated with higher baseline T2 values particularly in the patella, adjusted odds ratio (OR) per 1 SD increase in T2: 3.37 (95% CI: 1.72; 6.62), but also in the medial femur: 1.90 (1.07; 3.39), lateral femur: 2.17 (1.11; 4.25) and lateral tibia: 2.23 (1.16; 4.31). Conclusions These findings suggest that T2 values assessed when radiographic changes are not yet apparent may be useful in predicting the development of radiological tibiofemoral OA.

show abstract

“…In a three year study, 24% of patients had radiographic signs of OA in the patellofemoral joint, 4% in the tibiofemoral joint, and 41% in both regions of the knee. 7 With these differences in prevalence of OA, understanding the differences of healthy cartilage and the resilience to injury between different joints can help facilitate the development of OA therapeutics, particularly joint-specific treatments.…”

Section: Introductionmentioning

confidence: 99%

Joint-dependent response to impact and implications for post-traumatic osteoarthritis

Novakofski

Berg

Bronzini

et al. 2015

Osteoarthritis and Cartilage

View full text Add to dashboard Cite

Objective The prevalence of osteoarthritis (OA) varies between joints. Cartilage in eight different joints was evaluated to elucidate the disparate susceptibilities between joints to post-traumatic OA (PTOA) and provide evidence for joint specific clinical treatments. The hypothesis was that cartilage in different joints would have varying cell death and anabolic gene expression profiles after injury. Methods Adult equine cartilage explants were harvested from shoulder (SH), elbow (EL), carpal (CA), metacarpophalangeal (MC), patellofemoral (FP), tarsal (TA), metatarsophalangeal (MT), and proximal interphalangeal (PP) joints, and were injured by loading with 30 MPa within 1 second. Fractional dissipated energy, cell density, cell death, and gene expression were quantified. Results PP had the highest fractional dissipated energy (94%, 95% confidence interval [CI] 88–101%). Cell density was most dense in superficial zone in all samples, with MC and MT having the highest peak density. Injured samples had significantly higher cell death (13.5%, 95% CI 9.1–17.9%) than non-injured samples (6.8%, 95% CI 2.5–11.1%, p=0.016); however, cell death after injury was not significantly different between joints. Gene expression was significantly different between joints. CD-RAP expression in normal cartilage was lowest in FP (Cp=21, 95% CI −80–122). After injury, the change in CD-RAP expression increased and was highest in FP (147% relative increase after injury, 95% CI 64–213). Conclusion Different joints have different baseline characteristics, including cell density and gene expression, and responses to injury, including energy dissipation and gene expression. These unique characteristics may explain differences in OA prevalence and suggest differences in susceptibility to PTOA. Clinical Relevance Understanding differences in the response to injury and potential susceptibility of OA can lead to the development of preventative or treatment strategies.

show abstract

Incidence, progression and sequence of development of radiographic knee osteoarthritis in a symptomatic population

Cited by 112 publications

References 30 publications

The effectiveness of proprioceptive-based exercise for osteoarthritis of the knee: a systematic review and meta-analysis

The effectiveness of proprioceptive-based exercise for osteoarthritis of the knee: a systematic review and meta-analysis

Early T2 changes predict onset of radiographic knee osteoarthritis: data from the osteoarthritis initiative

Joint-dependent response to impact and implications for post-traumatic osteoarthritis

Contact Info

Product

Resources

About