Incidence Rate for Hantavirus Infections without Pulmonary Syndrome, Panama

Armién, Blas; Pascale, Juan Miguel; Muñoz, Carlos; Lee, Sang-Joon; Choi, Kook; Avila, Mario; Broce, Candida; Armién, Aníbal G.; Gracia, Fernando Pérez de; Hjelle, Brian; Koster, Frederick

doi:10.3201/eid1710.101717_article.htm

Cited by 3 publications

(10 citation statements)

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“…The second cohort included 15 convalescent subjects (blood collection between 2 and 6 years after disease). The third cohort included 33 asymptomatic subjects (seropositive) who presented IgG antibodies against the nucleoprotein (N) protein of hantavirus but without a history of acute respiratory disease ( 8 ). A fourth cohort composed of 25 healthy subjects (seronegative) with no detectable levels of IgG antibodies against the N protein of hantavirus was defined as the control group.…”

Section: Methodsmentioning

confidence: 99%

“…This is in contrast to other NWHs that circulate around the Americas, with mortality rates between 35-40%. The highest incidence of CHOV infections have been detected in the provinces of Los Santos (61.4%), Veraguas (16.2%), Cocle (13.5%), and Herrera (6.6%), which are all considered endemic regions in Panama (8). These areas also showed a high percentage of asymptomatic CHOV-seropositive individuals, which ranged from 16 to 62% depending on the geographical area (8)(9)(10)(11).…”

Section: Introductionmentioning

confidence: 99%

“…However, CHOV infections cause a wide range of clinical manifestations from asymptomatic infection to more serious expressions of HCPS (9). Despite the potential range of disease severity, CHOV infections are often mild and characterized by fever, weakness, headache, myalgia, and sometimes gastrointestinal disorder (8)(9)(10)(11). In fact, the finding of a high prevalence of seropositive population implies that a large number of CHOV infections are asymptomatic with little to no clinical symptoms and no clinical record (8,10).…”

Section: Introductionmentioning

confidence: 99%

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Cytokine Profiles and Antibody Response Associated to Choclo Orthohantavirus Infection

et al. 2021

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BackgroundNew World Hantaviruses (NWHs) are the etiological agent underlying hantavirus cardiopulmonary syndrome (HCPS), a severe respiratory disease with high mortality rates in humans. In Panama, infections with Choclo Orthohantavirus (CHOV) cause a much milder illness characterized by higher seroprevalence and lower mortality rates. To date, the cytokine profiles and antibody responses associated with this milder form of HCPS have not been defined. Therefore, in this study, we examined immune serological profiles associated with CHOV infections.MethodsFor this retrospective study, sera from fifteen individuals with acute CHOV-induced HCPS, were analyzed alongside sera from fifteen convalescent phase individuals and thirty-three asymptomatic, CHOV-seropositive individuals. Cytokine profiles were analyzed by multiplex immunoassay. Antibody subclasses, binding, and neutralization against CHOV-glycoprotein (CHOV-GP) were evaluated by ELISA, and flow cytometry.ResultsHigh titers of IFNγ, IL-4, IL-8, and IL-10 serum cytokines were found in the acute individuals. Elevated IL-4 serum levels were found in convalescent and asymptomatic seropositive individuals. High titers of IgG1 subclass were observed across the three cohorts analyzed. Neutralizing antibody response against CHOV-GP was detectable in few acute individuals but was strong in both convalescent and asymptomatic seropositive individuals.ConclusionA Th1/Th2 cytokine signature is characteristic during acute mild HCPS caused by CHOV infection. High expression of Th2 and IL-8 cytokines are correlated with clinical parameters in acute mild HCPS. In addition, a strong IL-4 signature is associated with different cohorts, including asymptomatic individuals. Furthermore, asymptomatic individuals presented high titers of neutralizing antibodies.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cytokine Profiles and Antibody Response Associated to Choclo Orthohantavirus Infection

et al. 2021

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“…Our results confirmed previous studies showing that increases in the amount of sugarcane can augment HCPS risk (Ruedas et al 2005;Armien et al 2009;. Our scenario predicted an augment of ~30% (or ~3.000 ha) of land occupied with sugarcane on average, for both cerrado and Atlantic forest regions, until 2050, predicting increases of ~15% in HCPS risk.…”

Section: Sugarcane Expansion and Hcps Risksupporting

confidence: 90%

“…Nowadays there are evidences that only variations in temperature affect HCPS risk in Brazil, with precipitation showing no effect , Sugarcane plantations may be also associated with increases in Hantavirus infection risk Armien et al 2009;.…”

Section: Introductionmentioning

confidence: 99%

Hantavirus transmission risk in function of climate and landscape structure

Prist¹

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Hantavirus Cardiopulmonary Syndrome (HCPS) is a disease caused by Hantavirus, which are negative-sense RNA viruses in the family Bunyaviridae. These viruses are highly virulent to humans, taking about 50% of infected people to death. The main Hantavirus reservoir is constituded by generalist rodents species, which increase in abundance in agricultural and fragmented landscapes, potencially augmenting the transmission risk of the disease. Climate can also affect rodent population dynamics and the virus survival in the environment, as well as the time it remains virulent, while social factors may regulate the processes of transmitting viruses from reservoirs to humans. However, despite the high virulence of these viruses and the lack of vaccine is not yet well established how these different factors linked to landscape structure, climate and social conditions affect the dynamics of transmission of the disease. Thus, this study aimed to: 1) identify which social and ecological factors affect the transmission of HCPS, identifying the areas of greatest risk in the state of São Paulo and 2) predict how climate change (RCP4.5 and RCP8.5) and expansion of sugarcane scenarios influence the transmission of HCPS. To answer these questions the study system corresponded to the 645 municipalities that compose the state of São Paulo. To achieve our goals, in a first chapter, we conducted a literature review to understand how landscape structure and climate variables affect the risk of HCPS. In a second chapter we used a Bayesian model to quantify the association between HCPS annual incidence in the state of São Paulo, obtained by the number of cases confirmed by the Ministry of Health, between the years 1993-2012, and climate variables (total annual precipitation and mean annual temperature), landscape structure (percentage of native vegetation, number of fragments and percentage of area occupied with sugarcane), chosen in the literature review, and social factors (number of rural men over 14 years-risk population, and the Human Development Index-HDI). We build separate models for the Atlantic Forest and the Cerrado. In both biomes, the risk of HCPS increased mainly with the proportion of land cultivated with sugarcane and the HDI, but the proportion of native habitat, mean annual temperatures and risk population also showed positive relationships to Atlantic Forest. The average risk of HCPS for the state of São Paulo was 1.3%, with 6% of the municipalities being classified as medium to high risk (≥ 5%). In a third chapter we used sugarcane expansion and extracted temperature anomalies of RCP4.5 and RCP8.5 scenarios of general circulation models (GCMs) of IPCC5 to predict HCPS risk. With sugarcane expansion, average risk for HCPS increases from 1.3 to 1.5%, while RCP4.5 and RCP8.5 scenarios increased the risk to 1.6% and 1.7%, respectively. RCP4.5 and RCP8.5 scenarios alone are responsible for the largest increase in the maximum risk of infection (46.1% to 51.4% and 51.7%), while the sugarcane expansion combined with climate sc...

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Human hantavirus infections: epidemiology, clinical features, pathogenesis and immunology

Manigold¹,

Vial²

2014

Swiss Med Wkly

104

150

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In humans, hantaviruses can cause haemorrhagic fever with renal syndrome (HFRS) or hantavirus cardiopulmonary syndrome (HCPS). Currently it is estimated that 150,000 to 200,000 cases of hantavirus disease occur each year, the majority being reported in Asia. However, human hantavirus infections are increasingly reported in the Americas and Europe. Although many of the underlying pathogenic mechanisms still remain unclear, recent evidence rather argues against a purely immune-mediated pathophysiology of human disease. Despite the high morbidity and case-fatality rates of HFRS and HCPS, respectively, no vaccine or drug is currently proven to be preventive or therapeutic. This review summarises clinical features and current epidemiological findings, as well as concepts regarding the immunology, pathogenesis and intervention strategies of human hantaviral diseases.

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Incidence Rate for Hantavirus Infections without Pulmonary Syndrome, Panama

Cited by 3 publications

References 6 publications

Cytokine Profiles and Antibody Response Associated to Choclo Orthohantavirus Infection

Cytokine Profiles and Antibody Response Associated to Choclo Orthohantavirus Infection

Hantavirus transmission risk in function of climate and landscape structure

Human hantavirus infections: epidemiology, clinical features, pathogenesis and immunology

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