Incidence rate of ovarian cancer cases in Saudi Arabia: an observational descriptive epidemiological analysis of data from Saudi Cancer Registry 2001–2008

Abstract

PurposeThis study provides descriptive epidemiological data, such as the percentage of cases diagnosed, crude incidence rate (CIR), and age-standardized incidence rate (ASIR) of ovarian cancer in Saudi Arabia from 2001–2008.Patients and methodsA retrospective descriptive epidemiological analysis of all ovarian cancer cases recorded in the Saudi Cancer Registry (SCR) from January 2001–December 2008 was performed. The data were analyzed using descriptive statistics, analysis of variance tests, Poisson regression, and simple linear modeling.ResultsA total of 991 ovarian cancer cases were recorded in the SCR from January 2001–December 2008. The region of Riyadh had the highest overall ASIR at 3.3 cases per 100,000 women, followed by the Jouf and Asir regions at 3.13 and 2.96 cases per 100,000 women. However, Hail and Jazan had the lowest rates at 1.4 and 0.6 cases per 100,000 women, respectively. Compared to Jazan, the incidence rate ratio for the number of ovarian cancer cases was significantly higher (P<0.001) in the Makkah region at 6.4 (95% confidence interval [CI]: 4.13–9.83), followed by Riyadh at 6.3 (95% CI: 4.10–9.82), and the eastern region of Saudi Arabia at 4.52 (95% CI: 2.93–6.98). The predicted annual CIR and ASIR for ovarian cancer in Saudi Arabia could be defined by the equations 0.9 + (0.07× years) and 1.71 + (0.09× years), respectively.ConclusionWe observed a slight increase in the CIRs and ASIRs for ovarian cancer in Saudi Arabia from 2001–2008. Riyadh, Jouf, and Asir had the highest overall ASIR, while Jazan and Hail had the lowest rates. Makkah, Riyadh, and the eastern region of Saudi Arabia had the highest incidence rate ratio for the number of ovarian cancer cases. Further analytical studies are required to determine the potential risk factors of ovarian cancer among Saudi women.

Histopathological patterns of primary malignant ovarian neoplasms in different age groups in Almadinah Almunawwarah region, KSA

“…Germ cell tumours in our study were defined in 13% of cases, which is within the reported range in other studies 7 and is similar to other regions in KSA 27 …”

“…The mean age of the patients in this study was 41 years. This age is younger than that described in other regional studies with a comparable range from 7 to 91 years in both studies, and most cases were observed in the 20–50 age group, which was obviously younger than that of other findings in different regional studies 5, 27. These findings indicated the need of investigating the genetic predisposition of different ovarian malignant neoplasms in the Almadinah Almunawwarah region.…”

Facts about ovarian cancer in Maysanian women

“…For all patients in this study, the typical presentation was late; stages III and IV were seen in 76% of the cases. Similar results, with 78% of stage III or IV cases, have also been reported (22) . Another study found that stages III and IV accounted for only 56.2% of their cases (21) .…”

“…This study revealed that in Cypriots and US SEER data, most patients with ovarian cancer were in the age group from 50 to 69, while in Egypt and Jordan, most patients were below the age of 50 years (20) . Ovarian cancer distribution by age in Saudi Arabia in 2008 was 32% in patients aged 45-59 years, 31% in patients aged 60-74 years, and 3.7% in patients aged 0-14 years (22) , while in the United Kingdom it was 70.6% in women aged 75-79 years (23) .…”

Prevalence, spectrum, and founder effect of BRCA1 and BRCA2 mutations in epithelial ovarian cancer from the Middle East

“…OC in Saudi Arabia accounts for 2.9% of all cancers (Al‐Shahrani et al, ), whereas it accounts for 3.4% in Western population (Bray et al, ). Furthermore, OC in Saudi population has unique characteristics such as lower median age at presentation (55 years in Saudi vs. 65 years in Western population; Alghamdi et al, ; Al‐Shabanah et al, ; Torre et al, ), advanced stage (Al‐Badawi et al, ), and higher incidence of mucinous carcinomas (19% vs. 3% in Western population; Al‐Badawi et al, ; Perren, ; Xu, Rush, Rickett, & Coward, ). It is believed that nearly 5–12% of invasive EOC are caused by hereditary susceptibility (Risch et al, ; Whittemore, ).…”