Incidence rates and characteristics of pediatric onset psychogenic nonepileptic seizures

Hansen, Anne Sofie; Rask, Charlotte Ulrikka; Rodrigo-Domingo, Maria; Pristed, Sofie Gry; Christensen, Jakob; Nielsen, René Ernst

doi:10.1038/s41390-020-0945-z

Cited by 24 publications

(44 citation statements)

References 52 publications

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“…However, the EEG criteria were modified, and EEG information was missing or not performed in 13% of the cases. In the Danish study, the highest incidence rate was found among 16‐year‐old patients, with a 3.3‐fold higher incidence rate at 7.9/100 000/year, which is consistent with our findings 13 …”

Section: Discussionsupporting

confidence: 92%

“…Among our patients, 13% (11 of 84) had either confirmed or probable comorbid epilepsy. Previous studies on the incidence of PNES have found 14.2%–50% with comorbid epilepsy 11–13 . A meta‐analysis reported the frequency of epilepsy in patients with PNES to be 22% 23 .…”

Section: Discussionmentioning

confidence: 99%

“…Incidence rates of between 1.4 and 4.9/100 000/year have been reported from different adult populations 10–12 . A recent nationwide study in a Danish pediatric population showed an incidence of 2.4/100 000/year 13 …”

Section: Introductionmentioning

confidence: 99%

“…[10][11][12] A recent nationwide study in a Danish pediatric population showed an incidence of 2.4/100 000/year. 13 PNES prevalence is difficult to determine and has not been directly measured. A long delay from onset to diagnosis and patients with PNES disengaging from medical follow-up are considerable obstacles for epidemiological studies.…”

Section: Introductionmentioning

confidence: 99%

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Incidence and prevalence of psychogenic nonepileptic seizures in a Norwegian county: A 10‐year population‐based study

et al. 2021

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidence and prevalence of psychogenic nonepileptic seizures in a Norwegian county: A 10‐year population‐based study

et al. 2021

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“…As against published incidence rates of 1.4-4.9/ 100,000/ year, this group has identified an increasing incidence of PNES with maximum incidence of 7.4/100,000 person years in 2014. 6 Etiology of PNES. There is no single etiological theory to explain PNES.…”

Section: How Do Findings Of This Population Study Tie In Into Diagnosis and Treatment Gaps As Identified By Ilae In Pediatric Pnes?mentioning

confidence: 99%

Furthering the Evidence of Comorbid Psychiatric Disorders in Pediatric Patients With Psychogenic Nonepileptic Seizures

Joshi

2021

Epilepsy Curr

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Objective: Knowledge regarding psychiatric disorders in children and adolescents with psychogenic nonepileptic seizures (PNES) is limited. This study outlines the spectrum and risk of psychiatric disorders in childhood-onset PNES. Methods: We performed a nationwide matched cohort study of children and adolescents with PNES 5 to 17 years of age at the time of diagnosis between January 1, 1996, and December 31, 2014. Two matched comparison groups were included: children and adolescents with epilepsy (ES), and children and adolescents without PNES or epilepsy, called healthy controls (HC). Outcomes were prevalent psychiatric disorders before index (i.e., date of diagnosis or corresponding date for HC) and incident psychiatric disorders 2 years after index. Relative risks (RRs) were calculated and adjusted for potential confounders. Results: We included 384 children and adolescents with validated PNES, 1,152 with ES and 1,920 HC. Among the cases of PNES, 153 (39.8%) had prevalent psychiatric disorders and 150 (39.1%) had incident psychiatric disorders. Compared to the ES and HC groups, children and adolescent with PNES had elevated risks of both prevalent psychiatric disorders (adjusted RRPNES/ES = 1.87, 95% confidence interval [CI] 1.59-2.21, adjusted RRPNES/HC = 5.54, 95% CI 4.50-6.81) and incident psychiatric disorders (adjusted RRPNES/ES = 2.33, 95% CI 1.92-2.83, adjusted RRPNES/HC = 8.37, . A wide spectrum of specific psychiatric disorders displayed elevated RRs. Conclusions: Children and adolescents with PNES are at higher risk of a wide range of psychiatric disorders compared to children and adolescents with ES and HC. A careful psychiatric evaluation is warranted to optimize and individualize treatment.

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Funktionelle neurologische Störungen

Popkirov

Weber

2023

Transition Bei Neurologischen Erkrankungen

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Incidence rates and characteristics of pediatric onset psychogenic nonepileptic seizures

Cited by 24 publications

References 52 publications

Incidence and prevalence of psychogenic nonepileptic seizures in a Norwegian county: A 10‐year population‐based study

Incidence and prevalence of psychogenic nonepileptic seizures in a Norwegian county: A 10‐year population‐based study

Furthering the Evidence of Comorbid Psychiatric Disorders in Pediatric Patients With Psychogenic Nonepileptic Seizures

Funktionelle neurologische Störungen

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