Incidence rates of atopic dermatitis, asthma, and allergic rhinoconjunctivitis in Danish and Swedish children

Stokholm, Lonny; Simonsen, Jacob; Hærskjold, Ann; Linder, Marie; Kieler, Helle; Thomsen, Simon Francis; Stensballe, Lone Graff

doi:10.1016/j.jaci.2015.02.003

Cited by 120 publications

(149 citation statements)

References 27 publications

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“…Though the prevalence of atopic dermatitis (AD) is highest in childhood, the chronic nature of the disease imposes a burden to the patient and society also in adulthood. Recent studies report a prevalence of 6–10%, in adults, which is higher than previously reported . Furthermore, a Danish study found persistent AD in 50% of an adult population diagnosed with AD in school age .…”

Section: Introductionmentioning

confidence: 71%

Atopic dermatitis is associated with increased use of social benefits: a register‐based cohort study

Slagor

Nørreslet

Ebbehøj

et al. 2019

Acad Dermatol Venereol

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Background The comprehensive consequences of atopic dermatitis (AD) include a negative influence on work life. However, data regarding use of social benefits in patients with AD are sparse. Objective To examine the association between AD and use of social benefits, with a specific focus on paid sick leave and disability pension. Methods The study cohort comprises citizens born in the period 1964–1999 with a diagnosis of AD registered in the Danish National Patient Registry (DNPR) and a 20‐fold match control group from the background population. Cross‐linkage of data from 1964 up to 2015 by four national registers (the DNPR; the Central Person Register; the Register of Medicinal Product Statistics; and the Danish Register for Evaluation of Marginalisation) enabled the comparison of AD patients and controls with respect to social benefits. Prescription of systemic medication served as a proxy for AD severity. Social benefits were analysed as a function of AD status using Cox regression. Results A total of 28 156 AD patients were registered in the DNPR, and the control group comprised 473 836 individuals not registered with AD in the DNPR. AD was found to be associated with increased risk of receiving social benefits, paid sick leave in particular, and most pronounced for younger patients with severe AD (OR = 1.37, 95% CI: 1.25–1.52). The use of disability pension was increased for all groups of AD patients compared to controls and most pronounced for older patients with severe AD [HR 1.67 (95% CI: 1.45–1.93)]. Conclusion Our data emphasize that AD significantly impacts work life negatively for the patients and is a financial burden for the society.

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Section: Introductionmentioning

confidence: 71%

Atopic dermatitis is associated with increased use of social benefits: a register‐based cohort study

Slagor

Nørreslet

Ebbehøj

et al. 2019

Acad Dermatol Venereol

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“…To diagnose atopic dermatitis, asthma or allergic rhinoconjunctivitis on a population level remains a challenge. Register‐based research offers unique possibilities of epidemiologic and pharmaco‐epidemiologic studies on atopic dermatitis, asthma and allergy; however, studies evaluating the validity of the methods used are clearly warranted …”

Section: Discussionmentioning

confidence: 99%

“…Data on medication were obtained from The Danish National Prescription Registry, and data on hospital contacts were obtained from The Danish National Patient Register . The study population consisted of 972 836 live born Danish children born from 1997 to 2011 …”

Section: Methodsmentioning

confidence: 99%

“…The rates of atopic eczema, wheezing, asthma and allergic rhinoconjunctivitis, which have been increasing in high‐income countries, appear to be stabilizing at a level of 20%‐40% of the population being affected; however, the rates may still be increasing in low‐income countries . Large local variabilities in the prevalence of atopic diseases have been documented globally in the most recent report from The International Study of Asthma and Allergies in Childhood .…”

Section: Introductionmentioning

confidence: 99%

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The validity of register data to identify children with atopic dermatitis, asthma or allergic rhinoconjunctivitis

Stensballe

Klansø

Jensen

et al. 2017

Pediatric Allergy Immunology

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“…Their incidence and prevalence have continuously been rising in recent years [2], and millions of people around the world are affected [3]. The chronic inflammatory processes associated with allergic disorders, as e.g.…”

Section: Introductionmentioning

confidence: 99%

Atopic Patients Show Increased Interleukin 4 Plasma Levels but the Degree of Elevation Is Not Sufficient to Upregulate Interleukin-4-Sensitive Genes

Marbach-Breitrück

Kalledat

Heydeck

et al. 2019

Skin Pharmacol Physiol

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Background: Atopic diseases constitute a major health challenge for industrialized countries, and elevated levels of interleukin 4 (IL-4) frequently characterize these disorders. Previous in vitroanalyses have indicated that IL-4 strongly upregulates the expression of IL-4-sensitive genes in human monocytes. Objective: To explore whether similar expression alterations may contribute to the pathomechanisms of atopic diseases in vivo we carried out a small-scale case-control clinical study (n = 43), in which we quantified the plasma levels of IgE and IL-4 as well as the expression of selected IL-4-sensitive genes in blood leukocytes. Methods: 34 allergic patients suffering from allergic rhinitis (n = 11), atopic eczema (n = 11) and allergic asthma (n = 12) as well as 9 healthy control individuals were recruited. IgE and IL-4 plasma levels were determined by ELISA, and the expression of selected IL-4-sensitive gene products in blood leukocytes was quantified by qRT-PCR. In addition, the fatty acid oxygenase activity of isolated monocytes was measured by RP-HPLC analysis of the arachidonic acid oxygenation products (ex vivo activity assays). Results: We found that plasma levels of IgE and IL-4 were significantly elevated in atopic patients but the degree of elevation was not sufficient to upregulate the expression of the selected IL-4-sensitive genes in circulating leukocytes. Moreover, the arachidonic acid oxygenase activity of blood monocytes was not significantly altered in atopic patients. Conclusion: Our data suggest that the IL-4 plasma levels of atopic patients are not high enough to impact the expression of IL-4-sensitive genes.

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Incidence rates of atopic dermatitis, asthma, and allergic rhinoconjunctivitis in Danish and Swedish children

Cited by 120 publications

References 27 publications

Atopic dermatitis is associated with increased use of social benefits: a register‐based cohort study

Atopic dermatitis is associated with increased use of social benefits: a register‐based cohort study

The validity of register data to identify children with atopic dermatitis, asthma or allergic rhinoconjunctivitis

Atopic Patients Show Increased Interleukin 4 Plasma Levels but the Degree of Elevation Is Not Sufficient to Upregulate Interleukin-4-Sensitive Genes

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