Incidence rates of oral cancer and natural history of oral precancerous lesions in a 10‐year follow‐up study of Indian villagers

Gupta, Prakash C.; Mehta, Fali S.; Daftary, D. K.; Pindborg, J. J.; Bhonsle, R. B.; Jalnawalla, P. N.; Sinor, P. N.; Pitkar, V K; Murti, P. R.; Irani, R. R.; Shah, H.; Kadam, Prasad; Iyer, K S; Iyer, H. M.; Hegde, Ashwini; Chandrashekar, Gowri; Shiroff, B C; Sahiar, B E; Mehta, Mihir

doi:10.1111/j.1600-0528.1980.tb01302.x

Cited by 405 publications

(301 citation statements)

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“…The referent genotypes were considered on the basis of the highest proportion of a homozygous genotype at any particular p53 locus in the control group. An increased risk was indeed observed with increase in Arginine allele at codon 72 Arg/Pro locus (allele 2) in leukoplakia patients (P trend 5 0.0007), but the same was not significant for oral cancer 5 Mixed habituals have both types of habits simultaneously (smoking as well as smokeless tobacco). Light and heavy tobacco users are defined as the Ô< medianÕ and Ô medianÕ, respectively, for PY (i.e., 24) and CY (i.e., 120) in the control group, thereafter used in the other 2 subject groups (both cancer and leukoplakia).- 6 The number of samples genotyped are less than the total number of samples in Table 1 due to failure in PCR for one or more locus in 2 few samples even after repeated attempts.-OR, odds ratio; CI, confidence interval.…”

Section: Resultsmentioning

confidence: 92%

“…Control (682) 5 Exclusive smokeless of cancer vs. exclusive smokeless of control.-The number of samples haplotyped was less than the total number of samples in Table I due to failure in PCR for one or more locus in 2 few samples even after repeated attempts. Among the different p53 polymorphisms, the codon 72 Arg/ Pro, 16 bp at intron 3 and NciI at intron 6 (nt 13494) have been used in many studies.…”

Section: Discussionmentioning

confidence: 99%

“…In a 10-year prospective study, carried out in several geographic areas of India with various kinds of tobacco habits, annual age-adjusted incidence rates of leukoplakia per 1,000 individuals per year varied from 1.1-2.4 among men and 0.2-1.3 among women. 5 Oral leukoplakia has been reported to show a significant tendency to malignant transformation from 0.13-6% and rising to 14% or higher when dysplasia is present. 6 In Europe, USA, Australia, China and Japan, cigarette, cigar and pipe smoking are the main forms of tobacco use and the effect of tobacco is known, not only to be dose and time dependent but also to act synergistically with the intake of alcohol (spirits) to multiply disease risk.…”

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confidence: 99%

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Risk assessment of p53 genotypes and haplotypes in tobacco‐associated leukoplakia and oral cancer patients from eastern india

Mitra

Sikdar

Misra

et al. 2005

Intl Journal of Cancer

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The role of 3 p53 polymorphisms (16 bp duplication at intron 3, codon 72 Arg/Pro and intron 6 NciI RFLP at np 13494) as potential markers for indicating cancer risk remains inconclusive. In our case-control study consisting of 197 leukoplakia and 310 oral squamous cell carcinoma (SCC) patients and 348 controls, genotype frequencies at these 3 p53 loci were determined by PCR-RFLP method and analyzed by multiple logistic regression to determine the risks of the diseases. The 2/2 genotype at codon 72 of p53 was at risk for developing leukoplakia (OR 5 1.6, 95% CI 1.1-2.3), whereas the combination of 1/2 and 2/2 genotypes at intron 3 and 1/1 and 1/2 genotypes at intron 6 conferred a protective effect against leukoplakia and oral SCC development, respectively (OR 5 0.5, 95% CI 0.4-0.8 and OR 5 0.6, 95% CI 0.5-0.9, respectively). When subjects were stratified according to specific tobacco habit, the risk/protection estimates improved significantly in some cases. Specifically, the exclusive smokers with p53 codon 72 2/2 genotype showed a higher risk of developing leukoplakia (OR 5 2.7, 95% CI 1.2-6.3). Furthermore, a particular p53 haplotype 1-2-2 was at risk for both tobacco-associated leukoplakia and oral SCC (OR 5 1.5, 95% CI 1.1-1.9 and OR 5 1.3, 95% CI 1.1-1.7, respectively). Our results show that both specific p53 genotype and haplotype can indicate risk of tobacco-associated leukoplakia, but risk of development of tobacco-associated oral SCC can be predicted by specific p53 haplotype only. ' 2005 Wiley-Liss, Inc.

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Section: Resultsmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Risk assessment of p53 genotypes and haplotypes in tobacco‐associated leukoplakia and oral cancer patients from eastern india

Mitra

Sikdar

Misra

et al. 2005

Intl Journal of Cancer

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“…In each of the two study regions, potential villages that did not form part of an earlier intervention study (Gupta et al, 1980) or on-going case-control studies (Gupta et al, 1998(Gupta et al, , 1999 were identi®ed. Among these villages, 30 households were selected to represent the major religious ± economic classes.…”

Section: Field Methodsmentioning

confidence: 99%

Sources of variability in dietary intake in two distinct regions of rural India: implications for nutrition study design and interpretation

et al. 2000

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Objective: Limited inter-person variability in nutrient intake hampers epidemiologic studies of diet ± disease relationships. Despite conjecture about non-traditional study bases providing large inter-person differences, virtually nothing is known about variations in nutrient intake outside of Europe and North America. The current study was conducted in India to determine sources of variability in the intakes of nutrients thought to be of public health importance. Design: Adult subjects in Gujarat (North India; n 60) and in Kerala (South India, n 60) were administered 24 h diet recall interviews six and eight times, respectively, over a 1 y period. To assess subject (inter-person) and residual (intra-person) contributions to variance, regression models were ®t to the data. From this, the variance ratio (VR, total within or intra-person: total between or inter-person) was computed. Setting: Rural communities in North and South India. Results: In both regions, inter-person variability was larger than that observed in the West. This was most pronounced in Gujarat, for which the VR was`1.0 for seven of the 12 energy-adjusted nutrient intakes in both men and women. In analyses of the combined data, region accounted for b 20% of variance for fat, iron, copper, zinc, b-carotene and ribo¯avin in both men and women. With the region term removed from this model, virtually all of the variability ascribed to region contributed to inter-person variability. Conclusions:The relatively large inter-person variability observed here could contribute to improved`resolution' of diet ± outcome relationships in epidemiologic studies. While this applies to data from each region, it was especially evident in analyses of the combined data.

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“…An Indian house-to-house survey showed that about 80 % of oral cancers were preceded by oral pre-cancerous lesions or conditions [1].…”

Section: Introductionmentioning

confidence: 99%

Potentially Malignant Disorders of the Oral Cavity: A Clinical Study

Shukla¹

2013

Indian J Otolaryngol Head Neck Surg

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Oral cancers in India, unlike in the West are the most common cancers encountered, be it a primary or a tertiary referral practice. This makes the study and management of these cancers an important issue especially for the otolaryngologist. It is well known that the most common variant of oral cancers is the squamous cell carcinoma. Also the etiology is well established; with tobacco use in both smoking and smokeless forms, alcohol, betel nut and recently the Human Papilloma virus infection being implicated. Certain conditions which definitely increase the probability of getting oral cancers are known and this study aims in revisiting these aspects of premalignancy. The progression from a pre-cancerous lesion/ condition to frank cancer is well established across many studies and many specialties. Also timely recognizing these pre-cancerous conditions and administration of proper treatment will greatly help in reducing the morbidity and mortality from subsequent much advanced and dangerous oral cancer. Keeping these facts in mind this study was planned to study the established pre-cancerous lesions which are known to progress to oral cancers.

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Incidence rates of oral cancer and natural history of oral precancerous lesions in a 10‐year follow‐up study of Indian villagers

Cited by 405 publications

References 39 publications

Risk assessment of p53 genotypes and haplotypes in tobacco‐associated leukoplakia and oral cancer patients from eastern india

Risk assessment of p53 genotypes and haplotypes in tobacco‐associated leukoplakia and oral cancer patients from eastern india

Sources of variability in dietary intake in two distinct regions of rural India: implications for nutrition study design and interpretation

Potentially Malignant Disorders of the Oral Cavity: A Clinical Study

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