Incidence, Risk Factors, and Outcome of Suspected Central Venous Catheter-Related Infections in Critically Ill Covid-19 Patients: A Multicenter Retrospective Cohort Study

Abstract

Background: Aims of this study were to investigate the prevalence and incidence of catheter-related infection, identify risk factors, and determine the relation of catheter-related infection with mortality in critically ill COVID-19 patients. Methods: This was a retrospective cohort study of central venous catheters (CVCs) in critically ill COVID-19 patients. Eligible CVC insertions required an indwelling time of at least 48 hours and were identified using a full-admission electronic health record database. Risk factors were identified using logistic regression. Differences in survival rates at day 28 of follow-up were assessed using a log-rank test and proportional hazard model. Results: In 538 patients, a total of 914 CVCs were included. Prevalence and incidence of suspected catheter-related infection were 7.9% and 9.4 infections per 1,000 catheter indwelling days, respectively. Prone ventilation for more than 5 days was associated with increased risk of suspected catheter-related infection; odds ratio, 5.05 (95% confidence interval 2.12-11.0). Risk of death was significantly higher in patients with suspected catheter-related infection (hazard ratio, 1.78; 95% confidence interval, 1.25-2.53). Conclusions: This study shows that in critically ill patients with COVID-19, prevalence and incidence of suspected catheter-related infection are high, prone ventilation is a risk factor, and mortality is higher in case of catheter-related infection.

Risk factors and pathogenic bacteria of central venous catheter-associated bloodstream infection in patients with emergency hemorrhagic shock: a single-center retrospective Study from 2016 to 2022 in a Teaching Hospital in China

“…Central vein catheterization is one of the essential operations and has been widely used in clinical rescue of patients [19] . However, central vein catheterization technology, as an invasive operation technology, causes catheter-associated infection, which is a di cult problem for clinical medical staff [20] .…”

Infección Nosocomial: situación en España

“…Las cifras de infección bacteriémica pueden darse como una incidencia (proporción de todos los ingresados que sufren una bacteriemia de puerta de entrada en el catéter) o como una densidad de incidencia (utilizando como denominador los días totales que los pacientes tienen un catéter colocado y por tanto los días de exposición). Cifras de incidencia de CR-BSI puden oscilar entre 0,5 a 9 episodios por 1.000 ingresos [17][18][19] y la densidad de incidencia por 1.000 días de exposición entre 0,3 y 5,2 [20,21,22].…”