Incidence trends of mantle cell lymphoma in the United States between 1992 and 2004

Abstract

BACKGROUND. Mantle cell lymphoma (MCL) is a distinct subtype of B‐cell non‐Hodgkin's lymphoma. To the authors' knowledge, little is known regarding its incidence patterns and associated factors. The purpose of the current study was to examine the incidence of MCL over a period of 13 years and to identify the factors associated with the incidence patterns. METHODS. Patients diagnosed with MCL between 1992 and 2004 were identified from the Surveillance, Epidemiology, and End Results (SEER) Tumor registries. SEER*Stat statistical software was used for analysis. RESULTS. Of the 87,166 patients diagnosed with non‐Hodgkin's lymphoma during the 13‐year period between 1992 and 2004, 2459 (2.8%) had confirmed MCL. The overall incidence of MCL (per 100,000) was 0.55, which increased with age: 0.07 in patients aged <50 years, 2.97 in patients aged 70 to 79 years, and 2.78 in those aged ≥80 years. The age‐adjusted incidence rate increased from 0.27 of 100,000 in 1992 to 0.69 of 100,000 in 2004, and the annual percent change was 5.87% (P < .05). The median age at diagnosis was 68 years. The incidence of MCL was higher in men (0.84 of 100,000) than in women (0.34 of 100,000) (P < .05), and was higher in Caucasians (0.61 of 100,000) than in African Americans (0.32 of 100,000). Late‐stage (III‐IV) MCL was diagnosed in 74.6% of patients. There were significant geographic variations noted (P < .05). CONCLUSIONS. The incidence of MCL increased from 1992 to 2004, and was significantly higher in men, in Caucasians, and patients aged ≥50 years. Most patients were diagnosed with late‐stage MCL, and there also were considerable geographic variations observed in incidence rate. Cancer 2008. © 2008 American Cancer Society.

Mantle cell lymphoma: primary oral presentation

“…3 It is a well-defined lymphoid neoplasm that shows proliferation of B-lymphocytes. It is more common in men and its incidence increases with age, with the median age of diagnosis being 63 years.…”

“…It is more common in men and its incidence increases with age, with the median age of diagnosis being 63 years. 3 Extra-nodal involvement is common and it often presents at a late stage (III-IV) with leukaemic spread, bone marrow involvement, hepatosplenomegaly and lymphadenopathy. 4 Response to conventional chemotherapy and overall survival are both poor.…”

Mantle Cell Lymphoma: Current Concepts

“…Patients are much more commonly male and elderly [3] with a median age of onset of 68 years [4]. The disease is less frequent in Asian countries [4].…”

“…Patients are much more commonly male and elderly [3] with a median age of onset of 68 years [4]. The disease is less frequent in Asian countries [4]. Most cases are advanced at presentation and often exhibit complete responses to initial treatment followed by frequent relapses [3].…”

Emerging Therapy for the Treatment of Mantle Cell Lymphoma

“…It accounts for approximately 3% to 6% of all NHLs, with a median age at diagnosis of 68 years and a significant male predominance. 1,2 Most patients present with an advanced stage and a high-intermediate or high International Prognostic Index (IPI) score. Diffuse lymphadenopathy, splenomegaly, and bone marrow involvement are often seen at presentation, with most patients having extranodal disease, with a predilection for the gastrointestinal tract.…”