Incidences and risk factors of metachronous vulvar, vaginal, and anal cancers after cervical cancer diagnosis

Matsuo, Koji; Blake, Erin A.; Machida, Hiroko; Mandelbaum, Rachel S.; Roman, Lynda D.; Wright, Jason D.

doi:10.1016/j.ygyno.2018.07.016

Cited by 15 publications

(20 citation statements)

References 38 publications

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“…Так, теория «опухолевого поля», представленная R.A. Willis в 1967 г., подразумевает, что во всем объеме ткани, подвергающейся канцерогенному влиянию, могут возникнуть множественные очаги, представлен-ные одной или группой клеток потенциального опухолевого роста [4]. Кроме того, ряд авторов считают, что ПМЗО возникают на фоне воспалительных и дистрофических изменений в тканях, а также в результате метаболических, гормональных изменений, повышающих способность клеток к опухолевой трансформации [5,6].…”

Section: этиопатогенезunclassified

Management of patients with multiple primary сancer in the practice of a modern oncologist. Case report and literature review

Хланта

Генс

2022

Sib. onkol. ž.

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The purpose of the study. Multiple primary malignant neoplasms or polyneoplasia are a phenomenon of tumorigenesis and one of the little-studied categories in modern clinical oncology. The increase in the cancer incidence, as well as the need to make difficult decisions about further treatment strategy, enhance the relevance of studying multiple primary malignant neoplasms. This review discusses the current positions of medicine in relation to this category of malignant neoplasms, and presents a case report of a patient with this disaese. Material and methods. We have analyzed the results of international studies on the management of patients with multiple primary cancer. the search for relevant sources was carried out in the Web of Science, Scopus, Medline systems with a chronological interval of 2016–2021. of the analyzed studies, 60 were used to compile a systematic review with a case report. Results. The analysis showed that timely diagnosis and improvement of cancer screening programs are necessary to improve the control of these tumors. Psychological work with a patient, strengthening of his commitment to therapy and the implementation of medical recommendations are integral parts of improving cancer care for patients with such disease. Conclusion. A comprehensive analysis of multiple primary malignant tumors requires long-term follow-up of a large population, taking into account genetic factors, environmental factors, exposure to smoking and nutrition, and comorbid pathology. Timely diagnosis and improvement of cancer screening programs are necessary to improve the control of multiple primary malignant tumors.

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Section: этиопатогенезunclassified

Management of patients with multiple primary сancer in the practice of a modern oncologist. Case report and literature review

Хланта

Генс

2022

Sib. onkol. ž.

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“…Then, the assumption is made on the sth segment with a total number of pixels U, which E px shows each pixel in it. The center of the segmented cervical image is formulated using Equation (10).…”

Section: Objective Model Of Segmentationmentioning

confidence: 99%

“…9 Many image processing and screening methods are involved based on the optical image, but the optimal image contrast is low for the precancerous and cervix lesions. 10 Likewise, some popular techniques of using the lugols and acetic acid are integrated for highlighting the suspected cervix regions, where these generate low image values that need to be removed at a regular intervals of time. 11 Most of these techniques are expensive, and so, some researchers are focused on developing visual screening technologies of image processing for analyzing the images.…”

Section: Introductionmentioning

confidence: 99%

“…There are some detection tools such as “loop electrosurgical exclusion procedure (LEEP) and colposcopy” for cervical cancer detection 9 . Many image processing and screening methods are involved based on the optical image, but the optimal image contrast is low for the precancerous and cervix lesions 10 . Likewise, some popular techniques of using the lugols and acetic acid are integrated for highlighting the suspected cervix regions, where these generate low image values that need to be removed at a regular intervals of time 11 .…”

Section: Introductionmentioning

confidence: 99%

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Adaptive fuzzy‐region growing fusion and improved CNN‐ANFIS‐based automated segmentation and classification of cervical cancer

Jeyshri

Kowsigan

2022

Concurrency and Computation

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Summary The cervical cancer screening mechanisms help to classify cervical lesions into cancerous, precancerous, and normal. But, some of the classification approaches provide optimal outcomes based on the precise spotting and segmenting of cervical cancer. Moreover, still, challenges persist in the precise spotting of cervical cancer. The conventional screening methods for cervical cancer require more experienced pathologists, but it may also lead to poor efficiency and low accuracy. To overcome these issues, medical image processing introduces both machine learning and deep learning methods into cervical cell classification. The major scope of this task is to plan a new cervical cancer diagnosis method using intelligent approaches. Here, the segmentation of abnormality is done by the novel adaptive fuzzy‐region growing fusion model, which is improved by the hybridized optimization algorithm named gray wolf‐tunicate swarm algorithm (GW‐TSA). Then, the new ensemble classification termed Improved convolutional neural network with artificial neural network fuzzy inference system, which depends on the proposed GW‐TSA for performance enhancement through optimizing the hyperparameters. Finally, the simulation findings show that the designed approach is achievable and provides the highest accuracy rate in diagnosing cervical cancer.

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“…Significant progress has been made in reducing the incidence of some cancers, but the same cannot be said for some cancers of the female reproductive tract because a lack of a thorough understanding of their causes [ 128 , 129 ]. Cancers, including those of gynaecological origin, are distinguished by dysregulation of important cellular mechanisms, including those involved in the control of cell division, cellular differentiation, and apoptosis.…”

Section: Introductionmentioning

confidence: 99%

(Endo)Cannabinoids and Gynaecological Cancers

Taylor

Tortolani

Ayakannu

et al. 2020

Cancers

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Gynaecological cancers can be primary neoplasms, originating either from the reproductive tract or the products of conception, or secondary neoplasms, representative of metastatic disease. For some of these cancers, the exact causes are unknown; however, it is recognised that the precise aetiopathogeneses for most are multifactorial and include exogenous (such as diet) and endogenous factors (such as genetic predisposition), which mutually interact in a complex manner. One factor that has been recognised to be involved in the pathogenesis and progression of gynaecological cancers is the endocannabinoid system (ECS). The ECS consists of endocannabinoids (bioactive lipids), their receptors, and metabolic enzymes responsible for their synthesis and degradation. In this review, the impact of plant-derived (Cannabis species) cannabinoids and endocannabinoids on gynaecological cancers will be discussed within the context of the complexity of the proteins that bind, transport, and metabolise these compounds in reproductive and other tissues. In particular, the potential of endocannabinoids, their receptors, and metabolic enzymes as biomarkers of specific cancers, such as those of the endometrium, will be addressed. Additionally, the therapeutic potential of targeting selected elements of the ECS as new action points for the development of innovative drugs will be presented.

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Incidences and risk factors of metachronous vulvar, vaginal, and anal cancers after cervical cancer diagnosis

Abstract: Although rare, the rate of ano-genital cancers continues to increase over time after a cervical cancer diagnosis. Long-term follow-up and surveillance after cervical cancer treatment is therefore reasonable to detect these metachronous malignancies, particularly in those with risk factors.

Cited by 15 publications

References 38 publications

Management of patients with multiple primary сancer in the practice of a modern oncologist. Case report and literature review

Management of patients with multiple primary сancer in the practice of a modern oncologist. Case report and literature review

Adaptive fuzzy‐region growing fusion and improved CNN‐ANFIS‐based automated segmentation and classification of cervical cancer

(Endo)Cannabinoids and Gynaecological Cancers

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