Incidência de Candida spp. na mucosa oral de pacientes infectados pelo vírus da imunodeficiência humana (HIV) no município de Santo Ângelo -RS

Hartmann, Andreia; Missio, Raquel; Hammad, Marieli Peruzzi; Alves, Izabel Almeida

doi:10.17058/reci.v6i3.6556

Cited by 9 publications

(11 citation statements)

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“…This prevalence was similar to the values observed in people undergoing autologous bone marrow transplantation (40.7%) and asymptomatic PLHIV (51.3% and 52.5%), but lower than the values found in hospitalized HIV patients (50.4%, 53.5%, 73.3%, 73.4%, 80%, and 83%). [6,[22][23][24][25][26][27][28] It is important to consider the period and location of these studies (Brazil, China, Nigeria, Turkey) once the incidence of fungal infections has increased in developing countries due to the use of ART and new diagnostic methods. [29] Moreover, the participants in this study come from the outpatient clinics and not from the hospitals; hence, these participants may present basic pathologies that aggravate their clinical status.…”

Section: Discussionmentioning

confidence: 99%

Factors associated with the isolation of Candida Spp. from the oral microbiota of people living with HIV

Silva

Brito

et al. 2020

CNS

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This study aimed to analyze the association between the isolation of Candida species in the oral cavity and the clinical and virulence factors of people living with Human immunodeficiency virus (HIV). This cross-sectional study, comprising 106 people living with HIV who were evaluated in an HIV-AIDS outpatient clinic in Fortaleza, Northeast of Brazil, data collection were conducted during August and November 2018. A saliva sample was also collected to isolate Candida. The virulence factors of extracellular and hemolytic phospholipase activities in isolated Candida strains were analyzed. The prevalence of oral Candida was 40.6%, and the presence of oral Candida was associated with smoking habits (p = .005), daily smoking (p = .026), low weight (p = .030), history of hospitalization (p = .014), TCD4 lymphocyte count < 200 cells/mm3 (p = .018), and detectable viral load (p = .005). The multivariate analysis revealed that the variables smoking habits (p = .008), viral load (p = .011), and body mass index (p = .011) were associated with the presence of oral Candida. Strong hemolytic and phospholipase activities were, respectively, identified in 74.4% and 72% of the isolated strains, mainly Candida albicans. As a main conclusion, the isolation of Candida from the oral cavity in people living with HIV/AIDS, has a strong association with the use of tobacco, even under anappropriate treatment.

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Section: Discussionmentioning

confidence: 99%

Factors associated with the isolation of Candida Spp. from the oral microbiota of people living with HIV

Silva

Brito

et al. 2020

CNS

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“…Os achados mais comuns da mucosa oral, em ambos os sexos, foram periodontite grave (30%), candidíase pseudomembranosa (26%) e língua pilosa (26%). Davoodi P, et al (2010), ao analisarem 100 pacientes HIV positivos em um estudo transversal, selecionados aleatoriamente entre os participantes do Centro de Consulta Comportamental de Kermanshah, no Irã, observaram as seguintes manifestações clinicas no grupo analisado: cárie galopante (54), doença periodontal (44), hiperpigmentação (42), Candidíase eritematosa (36), xerostomia (20), queilite angular (17), leucoplasia (16), língua peluda (14), aumento de glândulas salivares (11), candidíase pseudomembranosa (7) e eritema gengival linear (6). Dentre as manifestações com menor ocorrência foram destacadas a leucoplasia pilosa (4), líquen plano da língua (4), línguas fissuradas (3), periodontite ulcerativa necrosante (2), verrugas orais (2), fibromas de irritação (2) e papiloma (1), evidenciando a diversidade de manifestações orais que podem ser observadas nesses pacientes.…”

Section: Revisão Bibliográficaunclassified

Manifestações orais em pacientes imunodeprimidos pelo Vírus da Imunodeficiência Humana (HIV): revisão da literatura

et al. 2021

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Objetivo: Descrever as manifestações orais em pacientes imunodeprimidos portadores do HIV. Métodos: Trata-se de uma Revisão de Literatura onde as buscas dos artigos científicos foram realizadas nas bases de dados Scientific Electronic Library Online (SciELO) e Literatura Latino-Americana em Ciências da Saúde (LILACS), cujo critério de inclusão foi, os artigos científicos realizados no Brasil, em língua portuguesa, que foram publicados no período de 2009 a 2020. Resultados: Nesta revisão da literatura foi possível evidenciar que as principais lesões orais relacionadas ao HIV constituem a candidíase oral, leucoplasia pilosa, sarcoma de Kaposi e Gengivite ulcerativa necrosante associada ao HIV, além de outras ulcerações recorrentes. Este estudo demonstra de forma detalhada as formas de tratamento para cada manifestação oral citada anteriormente. Considerações finais: A infecção pelo vírus da imunodeficiência humana (HIV) é uma pandemia caracterizada por alteração no sistema imunológico onde se observa uma progressiva depleção dos linfócitos T CD4+, o que propicia o aparecimento de infecções oportunistas, onde as manifestações orais provêm do surgimento dessas infecções e podem sinalizar uma imunossupressão nos indivíduos infectados pelo HIV.

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“…Portanto, o diagnóstico correto destas infecções e seu encaminhamento para um tratamento eficaz vai permitir uma maior qualidade de vida ao paciente. Hartmann et al (2016), em Santo Ângelo no RS, verificaram que dos 45 pacientes imunocomprometidos estudados, 53,3% deles estavam com infecção por Candida spp., destes 95,83% por Candida albicans.…”

Section: Introductionunclassified

Pharmaceutical care in the context of an Extension Project to care for patients with vaginal candidiasis with the strategy of carrying out antifungal resistance testing and community health prevention

et al. 2020

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Vaginal candidiasis, fungal infection caused by species of Candida spp. that affects women of all ages, cultures, habits, social and economic conditions. Its frequency and epidemiology is already reported, but resistance and therapeutic failures have been recorded. Methodology: In the Laboratory of Clinical and Toxicological Analyzes of the Faculty of Pharmacy of UFRGS (LACT), cervicovaginal collections of women were performed for Candida research and determination of species, after which susceptibility tests were performed to fluconazole, itraconazole, ketoconazole and nystatin. With the results obtained complement with the Pharmaceutical Care Project. Results: C. albicans was identified in 37% and in non-albicans species, C. glabrata in 27%. C. albicans was more sensitive to antifungals than C. glabrata, which presented a minimum inhibitory concentration (MIC) higher than C. albicans. Conclusion: Antifungal resistance has increased due to the use in prophylaxis and treatments without the correct diagnosis, requiring a more careful look at these patients. Thus, it is necessary to follow up the diagnosis and treatment by the health professional, the pharmacist, who has knowledge of the drug therapy used and this is obtained by the Pharmaceutical Care acting in the Project.

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Incidência de Candida spp. na mucosa oral de pacientes infectados pelo vírus da imunodeficiência humana (HIV) no município de Santo Ângelo -RS

Cited by 9 publications

References 10 publications

Factors associated with the isolation of Candida Spp. from the oral microbiota of people living with HIV

Factors associated with the isolation of Candida Spp. from the oral microbiota of people living with HIV

Manifestações orais em pacientes imunodeprimidos pelo Vírus da Imunodeficiência Humana (HIV): revisão da literatura

Pharmaceutical care in the context of an Extension Project to care for patients with vaginal candidiasis with the strategy of carrying out antifungal resistance testing and community health prevention

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