Incidencia y características de la tuberculosis en pacientes con enfermedades reumáticas autoinmunes

C, Vadillo Font; Hernández-Garcı́a, César; Pato, Esperanza; Ic, Morado; Salido, Marina; Júdez, Enrique; Macarrón, Pilar; Fernández‐Gutiérrez, Benjamín; Abásolo, Lydia; Ja, Jover

doi:10.1157/13045537

Cited by 16 publications

(6 citation statements)

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“…14 The only Spanish series published analysed 158 patients with SLE. 18 The authors reported three cases of TB (two pulmonary, one splenic), resulting in an incidence of 645 cases/100 000 person-years (95% CI 129-1931). Similar to our experience, all three patients responded well to standard antituberculous regimes with no fatalities.…”

Section: Summary Of Published Series (Table 1)mentioning

confidence: 99%

“…Our search obtained 10 series, [9][10][11][12][13][14][15][16][17][18] from Spain, Philippines, Hong Kong, Korea, India, Singapore, Turkey and Malaysia. The incidence of TB varied between 150/100 000 patient-years in Turkey and preceding TB infection, and, remarkably, all three affected patients had APS.…”

Section: Summary Of Published Series (Table 1)mentioning

confidence: 99%

“…[3][4][5][6][7][8] However, prospective data on this issue are scarce and the incidence and severity of TB in SLE patients varies greatly among different series. [9][10][11][12][13][14][15][16][17][18] Moreover, SLE patients are at increased risk for hepatotoxicity due to the frequent use of concomitant drugs with potential for liver damage. Due to these concerns, regular chemoprophylaxis with INH has not been performed in our unit.…”

Section: Introductionmentioning

confidence: 99%

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High risk of tuberculosis in systemic lupus erythematosus?

Erdozain

Ruiz‐Irastorza

Egurbide

et al. 2006

Lupus

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The incidence and severity of tuberculosis (TB) in patients with systemic lupus erythematosus (SLE) varies greatly among different series. In addition, prospective data are scarce. The aim of this study is to analyse the frequency and severity of TB in our cohort of lupus patients. We analysed data from a prospective database of a single center cohort of 232 patients with SLE (ACR criteria). Prophylaxis with isoniazid was not regularly administered. We identified all cases of TB diagnosed during 10 years (January 1994 to December 2003). The following variables were analysed: annual incidence of TB, location of infection and response to therapy. Data from published series reporting on the incidence of TB among SLE patients were extracted. Three patients (1.3%) suffered clinically manifest TB in 1603 patient-years of follow-up, resulting in an incidence of 187 cases/100,000 patient-years (95% CI 39-547). The pooled annual incidence of TB infection in our area during this period was 30/100,000 individuals. We recorded two cases of pulmonary TB and one case of tuberculous pleurisy. All patients had good response to therapy. The annual incidence of TB among SLE patients in other series, most of them from developing countries, varied between 150/100,000 patients in Turkey and 2450/100,000 patients in India. Of note, high prevalence of extrapulmonary forms as well as elevated TB-associated mortality was reported in most series. TB was more frequent in SLE patients than expected in the general population. We did not see any cases of disseminated infection and all patients had good response to treatment. Our data compare favourably in terms of incidence, severity and outcome with those from highly endemic areas.

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Section: Summary Of Published Series (Table 1)mentioning

confidence: 99%

Section: Summary Of Published Series (Table 1)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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High risk of tuberculosis in systemic lupus erythematosus?

Erdozain

Ruiz‐Irastorza

Egurbide

et al. 2006

Lupus

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“…Overall levels within the EU are improving. However, despite known underreporting in Spain, there are considerable differences between autonomous regions of Spain with respect to control of the disease [21]. …”

Section: Discussionmentioning

confidence: 99%

Diagnosis of Latent Tuberculosis in Patients with Systemic Lupus Erythematosus: T.SPOT.TBversusTuberculin Skin Test

Arenas-Miras

Hidalgo-Tenorio

Jiménez-Gámiz

et al. 2014

BioMed Research International

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Early studies in patients with systemic lupus erythematosus (SLE) reported increased incidence of tuberculosis. The tuberculin skin test (TST) is the technique of choice to detect latent tuberculosis infection (LTBI) but has several limitations. Objectives. We compared TST and the newer T.SPOT.TB test to diagnose LTBI in SLE patients. Methods. In this observational cohort study conducted between August 2009 and February 2012, we recruited 92 patients from those attending the SLE clinic of our university hospital. Data recorded were epidemiological and sociodemographic characteristics. Laboratory analyses included TST and T.SPOT.TB tests. Results. Of the patients studied, 92% were women with an average age of 42.7 years. Overall, the degree of correlation between the two tests was low (Kappa index = 0.324) but was better in patients not receiving corticosteroids (CTC)/immunosuppressive (IS) therapy (Kappa = 0.436) and in those receiving hydroxychloroquine (Kappa = 0.473). While TST results were adversely affected by those receiving CTC and/or IS drugs (P = 0.021), the T.SPOT.TB results were not. Conclusion. Although the TST test remains a useful tool for diagnosing LTBI in SLE patients, the T.SPOT.TB test is perhaps better employed when the patient is receiving CTC and/or IS drugs.

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“…Esto se debe a que la infección con M. tuberculosis es una condición necesaria pero insuficiente para la progresión a enfermedad tuberculosa. Entre estos se destacan la coinfección con el VIH; los tratamientos inmunosupresores (IS) (biológicos y corticoides) (12)(13)(14)(15)(16) ; edades extremas de la vida (17) ; ciertas comorbilidades como diabetes mellitus (DM) (18) ; desnutrición y la enfermedad renal crónica (ERC) (19 -21) .…”

Section: Introductionunclassified

Factores de riesgo en población no VIH con tuberculosis en Uruguay

Perez

Turnes

Suchi

et al. 2020

RUMI

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Fatores de risco na população não-HIV com tuberculose no Uruguai.Resumen: Objetivo: Describir las características de la población de personas de 18 años o más con tuberculosis (TB) no coinfectadas con Virus de la Inmunodeficiencia Humana (VIH) en Uruguay en el período del 1 de enero de 2016 al 31 de diciembre de 2017. Métodos: Se obtuvieron los datos de la base de datos anonimizada del registro nacional de TB perteneciente a la Comisión Honoraria de Lucha Antituberculosa y Enfermedades Prevalentes (CHLA-EP) para todos los casos de TB bacteriológicamente confirmada en el período del 1/1/16 al 31/12/17. Se excluyó a todos los individuos menores de 18 años y a todos aquellos con diagnóstico positivo para el VIH. Se clasificó a dichos individuos según el sector del sistema de salud de pertenencia. Se analizó la frecuencia y proporción de variables reconocidas como vinculadas a la enfermedad para cada subgrupo. Resultados: Se registraron 1129 casos. La tasa de incidencia de TB para la población de 18 años o más no infectada por el VIH fue de de 21,8 casos cada 100.000 habitantes para el año 2016. Se observó una proporción de factores de riesgo relacionados al medio socioeconómico de 43,8% del total de la población; estos predominaron en el sector público con un 57,4%. La pérdida de seguimiento para el sector público fue de 12,8%, mientras que en el sector privado fue de 3,0%. Se vió un porcentaje de fallecimiento de 38,8% entre los desocupados. Conclusiones: Los factores de riesgo socioeconómicos predominaron en el sector público de salud. Dentro de estos, la desocupación fue la de mayor proporción y se asoció con mayor porcentaje de fallecimiento y pérdida de seguimiento como resultado de tratamiento con respecto a la población general. La mayoría de los casos presentaron la forma pulmonar, y dentro de la extrapulmonar la más frecuente fue la pleural.

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Incidencia y características de la tuberculosis en pacientes con enfermedades reumáticas autoinmunes

Cited by 16 publications

References 0 publications

High risk of tuberculosis in systemic lupus erythematosus?

High risk of tuberculosis in systemic lupus erythematosus?

Diagnosis of Latent Tuberculosis in Patients with Systemic Lupus Erythematosus: T.SPOT.TBversusTuberculin Skin Test

Factores de riesgo en población no VIH con tuberculosis en Uruguay

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