Incident Apathy During the First Year After Stroke and Its Effect on Physical and Cognitive Recovery

Mikami, Katsunaka; Jorge, Ricardo E.; Moser, David J.; Jang, Mi-Jin; Robinson, Robert G.

doi:10.1016/j.jagp.2013.03.012

Cited by 32 publications

(23 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…We found no relation between the apathy and PA levels in our study. On the other hand, similar to the literature, we found that nearly 40% of the patients were apathetic during this phase (40).…”

Section: Discussionsupporting

confidence: 91%

Physical Activity Level of Ambulatory Stroke Patients: Is it Related to Neuropsychological Factors?

Hüseyinsinoğlu

Aslan

Tarakçı

et al. 2017

Arch Neuropsychiatr

View full text Add to dashboard Cite

Introduction: Physical inactivity is an important risk factor for stroke and stroke recurrence. There is insufficient knowledge about the physical activity (PA) level in stroke patients who are ambulatory in the subacute phase. Our aim was to compare the PA level between ambulatory stroke patients and a population of the same age and to investigate neuropsychological factors that could affect the PA level in the same stroke group.Methods: Eighty-five subacute stroke patients and 58 healthy subjects were included. Patients' demographic features, disease-related features, and comorbidities were recorded. The PA level was assessed by the International Physical Activity Questionnaire-Short Version and a pedometer (OMRON Walking style II). The Apathy Rating Scale was applied to determine the apathy level. Depression level was investigated by the Geriatric Depression Scale. The standardized Mini-mental State Examination was performed to assess the cognitive status.Results: The PA level was significantly higher in the healthy group than in the stroke group (p<0.001).Step count and walking distance were significantly higher in healthy group (p=0.001 and p=0.04, respectively). The PA level of men was significantly higher than that of women (p=0.03). Participants who were classified as level 4 had a lower PA level than those who were classified as level 5 according to the Functional Ambulation Category. There was no relationship between the PA level and the apathy, cognitive, and depression levels in the stroke patients (p>0.05). Conclusion:Subacute stroke patients have a lower PA level than healthy subjects. This is not related to neuropsychological factors. The reasons for minor deficits related to ambulation should be researched further while developing strategies for increasing the PA level of subacute stroke patients.Keywords: Stroke, apathy, depression, cognition, physical activity ABSTRACT 155level cannot be explained only by loss of motor function, psychological and cognitive factors have been proposed to analyze (13,14). In light of these findings, we aimed to compare the PA level between ambulatory stroke patients and a population of the same age and to investigate the demographic features and disease-related and neuropsychological factors that could affect the PA level in the same stroke group. We hypothesized that the PA level of ambulatory subacute stroke patients would be less than that of healthy subjects. We further hypothesized that the PA level would be affected by neuropsychological factors in the same population.

show abstract

Section: Discussionsupporting

confidence: 91%

Physical Activity Level of Ambulatory Stroke Patients: Is it Related to Neuropsychological Factors?

Hüseyinsinoğlu

Aslan

Tarakçı

et al. 2017

Arch Neuropsychiatr

View full text Add to dashboard Cite

show abstract

“…The few studies that provide longitudinal data of post-stroke apathy began assessment at least 1 month after stroke. Most found that apathy is rather stable over the 6–15 months post-stroke{3; 5; 7}, though one found that apathy lasts on average only for 6 months{8}.…”

Section: Discussionmentioning

confidence: 99%

Natural History of Poststroke Apathy During Acute Rehabilitation

Kennedy¹,

Granato

Goldfine³

2015

JNP

View full text Add to dashboard Cite

To better understand the natural history of post-stroke apathy, the authors tested 96 patients undergoing acute rehabilitation for stroke using the Apathy Inventory (AI). 28% of patients had apathy, and their AI scores improved on average 1 point by week 2 and 2 points by week 3 with the majority apathetic at discharge. Apathy severity correlated with aphasia, weakness, and impaired cognition, but not with depression. The findings suggest that acute rehabilitation is an optimal setting for clinical trials for post-stroke apathy because apathy is associated with poor outcomes and shows only a small degree of spontaneous improvement.

show abstract

“…The symptoms of apathy frequently overlap with depression but apathy is a syndrome distinct from clinical depression (6). The adverse consequences of apathy that have been documented include decreased recovery following stroke (7), increased stress in dementia caregivers and greater disability in depressed individuals (2,8). In Alzheimer's disease, apathy is a significant predictor of cognitive and functional decline, depression and parkinsonism (4).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Baseline PHQ-9 scores were also significantly different among the four conditions (Kruskall-Wallis H test, chi-square 8.29, df 3, P=0.04 ) with lower median depression scores at baseline (that approached statistical significance) in recovered compared with persistent apathy (2[2][3][4] vs 13[7][8][9][10][11][12][13][14][15][16], P=0.053). There were no differences in MMSE scores (Kruskall-Wallis H test, chi-square 6.63, df 3, P=0.09).…”

mentioning

confidence: 99%