Incidental and non-incidental thyroid microcarcinoma

Kaliszewski, Krzysztof; Wojtczak, Beata; Strutyńska−Karpińska, Marta; Łukieńczuk, Tadeusz; Forkasiewicz, Zdzisław; Domosławski, Paweł

doi:10.3892/ol.2016.4640

Cited by 17 publications

(25 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The median size of the cancer foci in the NITC group was larger than the ITC group, and the majority of the cancer foci in ITC group was microcarcinoma. In the majority of the previous studies, it was shown that the size of ITC was smaller than NITC . In our study, only five tumor foci were greater than 1 cm in the ITC group.…”

Section: Discussioncontrasting

confidence: 48%

“…In the majority of the previous studies, it was shown that the size of ITC was smaller than NITC. 2,17,18 In our study, only five tumor foci were greater than 1 cm in the ITC group. The rarity of ITC larger than 1 cm can be explained by routine evaluation of the majority of the nodules greater than 1 cm by FNA.…”

Section: Discussionmentioning

confidence: 49%

“…All ITC foci were histologically PTC, while 89.9% of NITC foci were PTC in our study. In the majority of other studies, it had been shown that the major histological type of tumor was PTC in ITCs . The median size of the cancer foci in the NITC group was larger than the ITC group, and the majority of the cancer foci in ITC group was microcarcinoma.…”

Section: Discussionmentioning

confidence: 92%

“…In the majority of other studies, it had been shown that the major histological type of tumor was PTC in ITCs. 2,17 The median size of the cancer foci in the NITC group was larger than the ITC group, and the majority of the cancer foci in ITC group was microcarcinoma. In the majority of the previous studies, it was shown that the size of ITC was smaller than NITC.…”

Section: Discussionmentioning

confidence: 98%

See 3 more Smart Citations

A cancer of undetermined significance: Incidental thyroid carcinoma

Evranos¹,

Polat

Cuhaci

et al. 2018

Diagnostic Cytopathology

View full text Add to dashboard Cite

Introduction The incidence of thyroid cancer is increasing which can be attributed in part to improved ultrasonography (US) methods and increased detection of incidental thyroid carcinomas (ITC). We aimed to compare ITC with nonincidental thyroid carcinomas (NITC) in this study. Methods Retrospective analyses of 906 individual patients who were operated for benign and malignant thyroid disease and had a final histopathological diagnosis of thyroid carcinoma were enrolled in this study. Preoperative US examination and fine needle aspiration (FNA) biopsy results were evaluated. The tumor foci in thyroidectomy specimens that were not represented in preoperative US or FNA reports were classified as ITC. The tumor foci that match with the lesions defined in US or FNA results were classified as NITC. Results Final histology revealed ITC in 326 patients (36%) and NITC in 580 patients (64% Mean age was 51.7 ± 11.11 in ITC group and 48.15 ± 13.1 in NITC group (P < .001). In NITC group 322 (55.5%) of the patients were operated for suspicious cytology while only 29 (8.9%) of the patients in the ITC group were operated because of this indication (P < .001). There were 1301 cancer foci in histopathology specimens. Among all these cancer foci, 434 (33.3%) were detected incidentally and 867 (66.7%) were detected non‐incidentally. About 779 (89.9%) of nonincidental cancer foci were papillary cancer (PTC), while all of the incidental cancer foci were PTC. Mean size was 13 mm in NITC group and it was 3 mm in the ITC group and differed significantly between the groups (P < .001). Tumor size was ≤1 cm in 35.2% of the patients with NITC while 98.5% of patients with ITC had tumor ≤1 cm. The occurrence of multinodularity was higher in ITC than the NITC group (P < 001). Median TSH level was higher in patients with NITC than ITC while both were in the reference range (1.53 vs 1.03 μIU/mL, P < .001). The frequency of thyroiditis detected by US, and thyroid peroxidase antibody and thyroglobulin antibody positivities were similar in patients with ITC and NITC (P = .2, P = .86, and P = .26, respectively). The frequencies of capsular invasion (29.1% vs 7.9%), extrathyroidal extension (13% vs 4.2%), multifocality (35.8% vs 24.2%), non‐complete resection (9.2% vs 1.8%), and lymph node metastasis (9.5% vs 1.8%) were significantly higher in the NITC group (P < .001, for each). Persistent/recurrent disease in patients with NITC was more frequent than patients with ITC (P = .004). This outcome was similar for cancers measuring ≤1 cm (P = .001). Conclusion ITC is often encountered in older patients and frequently determined in early stages with more favorable histopathological features and better prognosis.

show abstract

Section: Discussioncontrasting

confidence: 48%

Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 98%

See 2 more Smart Citations

A cancer of undetermined significance: Incidental thyroid carcinoma

Evranos¹,

Polat

Cuhaci

et al. 2018

Diagnostic Cytopathology

View full text Add to dashboard Cite

show abstract

“…The results of the study revealed that either LT-accompanied PTCs or MNH-accompanied IPTCs were more common than solely IPTCs. Yet, IPTCs with MNH were more common than IPTCs with LT [14,34]. In the present study, LT was defined as the presence of lymphocytic infiltrate with lymphoid follicles and oncocytic metaplasia in follicular epithelial cells regardless of the status of serum antibodies, and we ignored focally lymphocytic infiltrates during the assessment.…”

Section: Discussionmentioning

confidence: 99%

Comparison of clinicopathological features in incidental and nonincidental papillary thyroid carcinomas in 308 patients

Can¹,

Özyilmaz²,

Çelık³

et al. 2017

pjp

View full text Add to dashboard Cite

Incidental papillary thyroid carcinomas (IPTCs) consist of a significant portion of increasing incidence in papillary thyroid carcinomas. This study investigated the clinicopathological features of IPTCs from different perspectives and by comparing nonincidental PTCs (NIPTCs) in patients who underwent total thyroidectomy and lymph node dissection. Basic results were as follows. IPTC was present in 27.9% of 308 patients. IPTCs were significantly accompanied by lymphocytic thyroiditis (LT), particularly, multinodular hyperplasia (MNH). IPTCs were more common in older patients (51.3 years vs. 47.2 years) and in female patients. IPTCs significantly differed from NIPTCs in terms of smaller tumour size, lymphatic vessel invasion (2.6% vs. 97.4%), extrathyroidal extension (4.3% vs. 95.7%), lymph node metastasis (3.6% vs. 96.4%), multifocality (21.2% vs. 78.8%), bilaterality (5.3% vs. 94.7%), and BRAFV600 mutation (6.7% vs. 93.3%). Older age, bilaterality, encapsulation, and radioactive iodine (RAI) were significantly more common in IPTCs > 5 mm than in those ≤ 5 mm. In conclusion, IPTCs are more commonly associated with LT and MNH. IPTCs may have a more favourable prognosis than NIPTCs, and tumour size > 5 mm may predict bilaterality and need for RAI. Nevertheless, the patient-based clinical approach in IPTCs may have benefits in the management of IPTCs.

show abstract