Incidental Carcinoma after Cholecystectomy for Benign Disease of the Gallbladder: A Meta-Analysis

Pyo, Jung‐Soo; Son, Byoung Kwan; Lee, Hyoyoung; Oh, Il Whan; Chung, Kwang Hyun

doi:10.3390/jcm9051484

Cited by 20 publications

(11 citation statements)

References 55 publications

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“…Although cholecystectomy is not a difficult operation, more accurate preoperative prediction is warranted. Moreover, incidental GBCs in cases with polyps < 10 mm have frequently been reported 9,10 …”

Section: Introductionmentioning

confidence: 99%

“…Moreover, incidental GBCs in cases with polyps < 10 mm have frequently been reported. 9,10 Radiomics analysis allows for the quantitative analysis of a wide range of morphologic and physiologic properties of selected tissues, including shape and histogram-based and textural features. 11,12 Radiomics has been widely applied in the analysis of various organs and tissues such as the liver, breast, kidney, brain, and lung.…”

Section: Introductionmentioning

confidence: 99%

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A nomogram‐based model and ultrasonic radiomic features for gallbladder polyp classification

Zhang

Wang

et al. 2022

J of Gastro and Hepatol

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Background and Aim Gallbladder polyps (GBPs) are relatively common. Many studies have attempted to distinguish between benign and neoplastic GBPs to identify early‐stage gallbladder carcinoma. We have established an accurate neoplastic predictive model and evaluated the effectiveness of radiomics in predicting malignancy in patients with GBPs. Methods A total of 503 patients confirmed through postoperative pathology were included in this retrospective study. Clinical information and ultrasonographic findings were retrospectively analyzed. The model was constructed from independent risk factors using Spearman correlation and logistic regression analysis of a training cohort of 250 GBP patients, and its efficacy was verified using an internal validation group of 253 consecutive patients through the receiver operating characteristic curve (ROC). The area of GBPs was delimited manually, and the texture features of ultrasound images were analyzed using correlation and ROC analysis. Results Independent predictors, including age, gallstones, carcinoembryonic antigen, polyp size, and sessile shape, were incorporated into the nomogram model for the neoplastic potential of GBPs. Compared with other proposed prediction methods, the established nomogram model showed good discrimination ability in the training group (area under the curve [AUC]: 0.865) and validation group (AUC: 0.845). Regarding ultrasonic radiomics, the minimum caliper diameter was identified as the only independent predictor (AUC: 0.841). Conclusions Our preoperative nomogram model can successfully evaluate the neoplastic potential of GBPs using simple clinical data, and our study verified the use of radiomics in GBP identification, which may be valuable for avoiding unnecessary surgery in patients.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A nomogram‐based model and ultrasonic radiomic features for gallbladder polyp classification

Zhang

Wang

et al. 2022

J of Gastro and Hepatol

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“…The wide use of minimal invasive techniques has made the procedure extremely popular. Nearly 0.3-3% of the specimens present with a histological surprise (presence of malignancy) [ 12 - 13 ]. Almost all surgeons performing cholecystectomy encounter IGBC at least once in their professional carrier.…”

Section: Discussionmentioning

confidence: 99%

Does Timing of Completion Radical Cholecystectomy Determine the Survival Outcome in Incidental Carcinoma Gallbladder: A Single-Center Retrospective Analysis

Rahul¹,

Haldenia²,

Singh³

et al. 2022

Cureus

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Incidental discovery of gallbladder cancer (GBC) on postoperative histopathology or intra-operative suspicion is becoming increasingly frequent since laparoscopic cholecystectomy became the standard of care for gallstone disease. Incidental GBC (IGBC) portends a better survival than primarily detected GBC. Various factors affect the outcome of re-resection with the timing of re-intervention an important determinant of survival. MethodsAll patients of IGBC who underwent curative resection from January 2009 to December 2018 were considered for analysis. Details of demographic profile, index surgery, and operative findings on re-resection, histopathology and follow-up were retrieved from the prospectively maintained database. Patients were evaluated in three groups based on the interval between index cholecystectomy and re-resection: Early (<4 weeks), Intermediate (4-12 weeks) and Late (>12 weeks), using appropriate statistical tests. ResultsNinety-one patients were admitted with IGBC during the study period of which 48 underwent re-resection with curative intent. The median age of presentation was 55 years (31-77 years). The median duration of follow-up was 40.6 months (Range: 1.2-130.6 months). Overall and disease-free survival among the abovementioned three groups was the best in the early group (104 and 102 months) as compared to the intermediate (84 and 83 months) and late groups (75 and 73 months), though the difference failed to achieve statistical significance (p=0.588 and 0.581). On univariate analysis, factors associated with poor outcome were node metastasis, need for common bile duct (CBD) excision and high-grade tumor. However, on multivariate analysis, poor differentiation was the only independent factor affecting survival. ConclusionEarly surgery, preferably within four weeks, possibly entails better survival in incidentally detected GBC. The grade of a tumor, however, is the most important determinant of survival in IGBC.

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“…Moreover, incidental GBC in cases with polyps <10 mm have been reported. 10,11 Therefore, it is necessary to analyze other preoperative clinical characteristics and ultrasound findings that may be used to integrate variables with greater predictive value for GBP management. 12 The aim of this study was to develop a noninvasive, preoperative prediction model for assessing the malignancy risk of GBPs.…”

Section: Introductionmentioning

confidence: 99%

A Nomogram-based Model to Predict Neoplastic Risk for Patients with Gallbladder Polyps

Zhang

Wang

Qin

et al. 2021

J Clin Transl Hepatol

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Background and Aims: Gallbladder polyp (GBP) assessment aims to identify the early stages of gallbladder carcinoma. Many studies have analyzed the risk factors for malignant GBPs. In this retrospective study, we aimed to establish a more accurate predictive model for potential neoplastic polyps in patients with GBPs. Methods: We developed a nomogram-based model in a training cohort of 233 GBP patients. Clinical information, ultrasonographic findings, and blood test findings were analyzed. Mann-Whitney U test and multivariate logistic regression analyses were used to identify independent predictors and establish the nomogram model. An internal validation was conducted in 225 consecutive patients. Performance and clinical benefit of the model were evaluated using receiver operating characteristic curves and decision curve analysis (DCA), respectively. Results: Age, cholelithiasis, carcinoembryonic antigen, polyp size, and sessile shape were confirmed as independent predictors of GBP neoplastic potential in the training group. Compared with five other proposed prediction methods, the established nomogram model presented better discrimination of neoplastic GBPs in the training cohort (area under the curve [AUC]: 0.846) and the validation cohort (AUC: 0.835). DCA demonstrated that the greatest clinical benefit was provided by the nomogram compared with the other five methods. Conclusions: Our developed preoperative nomogram model can successfully be used to evaluate the neoplastic potential of GBPs based on simple clinical variables that maybe useful for clinical decisionmaking.

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Incidental Carcinoma after Cholecystectomy for Benign Disease of the Gallbladder: A Meta-Analysis

Cited by 20 publications

References 55 publications

A nomogram‐based model and ultrasonic radiomic features for gallbladder polyp classification

A nomogram‐based model and ultrasonic radiomic features for gallbladder polyp classification

Does Timing of Completion Radical Cholecystectomy Determine the Survival Outcome in Incidental Carcinoma Gallbladder: A Single-Center Retrospective Analysis

A Nomogram-based Model to Predict Neoplastic Risk for Patients with Gallbladder Polyps

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