Incidental Detection beyond Pathological Factors as Prognostic Predictor of Renal Cell Carcinoma

Ficarra, Vincenzo; Prayer-Galetti, Tommaso; Novella, Giovanni; Bratti, Emiliano; Maffei, N.; Bianco, M. Dal; Artibani, Walter; Pagano, Francesco

doi:10.1016/s0302-2838(03)00142-8

Cited by 84 publications

(38 citation statements)

References 28 publications

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“…Asymptomatic renal tumours were reported to have a favourable independent effect on prognosis in two large case series from Italy and Iceland (Ficarra et al, 2003;Palsdottir et al, 2012). This trend is similarly found in our RCC patients where symptomatic tumours predict shorter survival.…”

Section: Discussionsupporting

confidence: 84%

Clinical Prognostic Factors and Survival Outcome in Renal Cell Carcinoma Patients - A Malaysian Single Centre Perspective

Yap¹,

Ng²,

Ong³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionsupporting

confidence: 84%

Clinical Prognostic Factors and Survival Outcome in Renal Cell Carcinoma Patients - A Malaysian Single Centre Perspective

Yap¹,

Ng²,

Ong³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…2 Several recent studies have shown that the Fuhrman nuclear grading system is capable of predicting disease-specific survival in patients with RCC, regardless of pathologic stage. 12,15,[21][22][23] However, the reported 5-year disease-specific survival probabilities are extremely variable; stratified by grade, they are 50 -97% for patients with G1 tumors, 30 -90% for patients with G2 tumors, 10 -78% for patients with G3 tumors, and 9 -66% for patients with G4 tumors (Table 7). Moreover, prognostic stratification has been demonstrated only after patients are clustered into two or three different categories.…”

Section: Discussionmentioning

confidence: 99%

Original and reviewed nuclear grading according to the Fuhrman system

Ficarra

Martignoni

Maffei

et al. 2004

Cancer

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132

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BACKGROUNDThe objective of the current study was to evaluate the reproducibility of the Fuhrman nuclear grading system as well as its independent predictive value in a series of patients with conventional renal cell carcinoma (RCC).METHODSThe authors selected 388 patients who had undergone surgical treatment for conventional RCC between 1986 and 2000. Pathology slides from the selected patients were reviewed by a single pathologist, who reassigned a Fuhrman nuclear grade and assessed the presence of tumor necrosis. The pathologist was blinded to both the original pathologic diagnosis and follow‐up data. The κ statistic was used to evaluate concordance between original and reviewed nuclear grades. The log‐rank test was used for univariate analyses, and a Cox proportional hazards model was used for multivariate analyses.RESULTSThe original Fuhrman nuclear grade was Grade 1 (G1) in 111 patients (28.6%), G2 in 141 patients (36.3%), G3 in 108 patients (27.8%), and G4 in 28 patients (7.3%). After pathology slide review, nuclear grades were reassigned as follows: G1 in 49 patients (12.6%), G2 in 138 patients (35.6%), G3 in 150 patients (38.7%), and G4 in 51 patients (13.1%). The grade of concordance was moderate (κ = 0.44; P < 0.001). Univariate analyses identified three separate prognostic categories defined by nuclear grade (G1 and G2 vs. G3 vs. G4). Both the original and the reviewed Fuhrman nuclear grading systems were capable of independently predicting disease‐specific survival in patients with conventional RCC.CONCLUSIONSThe interobserver reproducibility of Fuhrman nuclear grading was moderate. The substantial overlap in survival curves for G1 and G2 tumors provided an opportunity to cluster those categories, and the resulting three‐tiered nuclear grading system was an independent predictor of cause‐specific survival in patients with conventional RCC. Other independent predictors of survival included pathologic stage and tumor necrosis status. Cancer 2005. © 2004 American Cancer Society.

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“…Grade 4 tümörleri Grade 3'ten ayıran özellik ise bizar, multilobüle nükleus ve kaba kromatin kümeleridir (7). Çeşitli çalışmalarda 5 yıllık sağkalım çok farklı oranlarda bildirilmektedir ve Grade 1 için %50-97, Grade 2 için %30-90, Grade 3 için %10-78, Grade 4 için %9-66 olarak oldukça farklılık göstermektedir (8)(9)(10). Çalışmamızda iki kez değerlendirilen hastalarda sağkalım Grade 1 için % 91-100, Grade 2 için %88-85, Grade 3 için %50-63 ve 4 için %15-15 olarak bulunmuştur.…”

Section: Discussionunclassified

Berrak Hücreli Renal Hücreli Karsinomda Fuhrman Derecesinin Tekrarlanabilirliğinin ve Prognostik Kullanımının Değerlendirilmesi

Özen¹,

Kasapoglu²,

Açıkalın³

et al. 2015

Osmangazi̇ Journal of Medicine

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Incidental Detection beyond Pathological Factors as Prognostic Predictor of Renal Cell Carcinoma

Cited by 84 publications

References 28 publications

Clinical Prognostic Factors and Survival Outcome in Renal Cell Carcinoma Patients - A Malaysian Single Centre Perspective

Clinical Prognostic Factors and Survival Outcome in Renal Cell Carcinoma Patients - A Malaysian Single Centre Perspective

Original and reviewed nuclear grading according to the Fuhrman system

Berrak Hücreli Renal Hücreli Karsinomda Fuhrman Derecesinin Tekrarlanabilirliğinin ve Prognostik Kullanımının Değerlendirilmesi

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