Incidental Detection of Retiform Hemangioendothelioma by 68Ga DOTATOC PET/CT

Vadrucci, Manuela; Vandoni, Andrea; Gilardi, Laura

doi:10.1097/rlu.0000000000001488

Cited by 6 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…5 Nevertheless, although 68 Ga-DOTATATE uptake has been described in many nonneuroendocrine tumors, no case of esophageal adenocarcinoma displaying 68 Ga-DOTATATE uptake has been reported before. [6][7][8][9] This particular case of metastatic esophageal adenocarcinoma showing 68 Ga-DOTATATE uptake highlights the potential of 68 Ga-DOTATATE PET/CT in imaging nonneuroendocrine tumors.…”

Section: Figurementioning

confidence: 78%

“…The presence of a significant number of somatostatin ( D ) cells in the columnar epithelium of the stomach and the association of Barrett esophagus as a precursor lesion in the majority of esophageal adenocarcinomas are considered to explain this SSTR expression 5 . Nevertheless, although 68 Ga-DOTATATE uptake has been described in many nonneuroendocrine tumors, no case of esophageal adenocarcinoma displaying 68 Ga-DOTATATE uptake has been reported before 6–9 . This particular case of metastatic esophageal adenocarcinoma showing 68 Ga-DOTATATE uptake highlights the potential of 68 Ga-DOTATATE PET/CT in imaging nonneuroendocrine tumors.…”

mentioning

confidence: 76%

See 1 more Smart Citation

Metastatic Esophageal Adenocarcinoma Showing 68Ga-DOTATATE Uptake

Fılızoglu,

Ozguven

2023

Clin Nucl Med

View full text Add to dashboard Cite

The role of 68Ga-DOTATATE PET/CT in the evaluation of neuroendocrine tumors is well defined. Nevertheless, 68Ga-DOTATATE uptake may be seen in some tumors other than neuroendocrine tumors as a reflection of tumor blood supply and somatostatin receptor expression. Although 68Ga-DOTATATE uptake has been described in a number of nonneuroendocrine tumors, no case of 68Ga-DOTATATE uptake in esophagus adenocarcinoma has been reported. We present the case of a 52-year-old man who had a metastatic esophageal adenocarcinoma showing 68Ga-DOTATATE uptake.

show abstract

Section: Figurementioning

confidence: 78%

mentioning

confidence: 76%

Metastatic Esophageal Adenocarcinoma Showing 68Ga-DOTATATE Uptake

Fılızoglu,

Ozguven

2023

Clin Nucl Med

View full text Add to dashboard Cite

show abstract

“…RH has also been detected by Ga-DOTA-tyr3-octreotide positron emission tomography–computed tomography. 13 Blood and urine tests are not yet specific. Lymph node ultrasonography is usually more valuable than sentinel lymph node biopsy, given that degenerative hemangioendothelioma rarely metastasizes.…”

Section: Discussionmentioning

confidence: 99%

Retiform hemangioendothelioma: a rare lesion of the vulva

et al. 2021

View full text Add to dashboard Cite

Retiform hemangioendothelioma (RH) is a rare borderline-malignant vascular tumor with specific histological characteristics, usually occurring in the limbs and trunk. We report the case of a 63-year-old woman who presented with a painless, oval nodule that had been growing slowly on her left vulva for 3 years. Magnetic resonance imaging of the pelvic cavity revealed a 4.4- × 2.7- × 1.8-cm cystic lesion in the subcutaneous fat of the left vulva. Resection beyond the macroscopic border was performed. Pathology revealed vascular structures with elongated and narrow arborizing vascular channels that were arranged in a retiform pattern resembling rete testis tissue. Immunohistochemical endothelial staining was positive for CD31, CD34, and Friend leukemia integration-1 (FLI-1). The above features confirmed a diagnosis of RH. There was no local recurrence or metastasis during the 26-month follow-up. RH of the vulva is rare, and its diagnosis is supported by specific histological characteristics and immunohistochemical staining for CD31, CD34, and FLI-1. Wide surgical resection with tumor-free margins is important for a favorable prognosis.

show abstract

“…Studies reporting incidental SSTR PET uptake in other locations were case studies (n = 7). Two cases proved to be malignant (29%), including retiform hemangioendothelioma in soft tissue and a non-Hodgkins lymphoma in a lymph node [15,27]. The remaining five benign cases revealed a pleomorphic adenoma in the parotid gland, parathyroid adenoma in close relation to the thyroid gland, elastofibroma dorsi in soft tissue, a uterine leiomyoma, and fibrous dysplasia in the femoral bone [8,[28][29][30][31].…”

Section: Miscellaneousmentioning

confidence: 99%

Prevalence and significance of incidental findings on 68 Ga-DOTA-conjugated somatostatin receptor-targeting peptide PET/CT: a systematic review of the literature

2022

View full text Add to dashboard Cite

Aim We aimed to evaluate the prevalence of incidental 68 Ga-DOTA-conjugated somatostatin receptor-targeting peptide PET/CT (SSTR PET/CT) findings, their clinical significance in the need for follow-up, and their risk of malignancy. Materials and methods Studies reporting incidental SSTR PET/CT findings were systematically searched in PubMed, Cochrane, Embase and Web of Science literature published prior to 1st of May 2020. Studies were filtered by two independent readers for eligibility based on title and abstract, and subsequently on full text. The main exclusion criteria were: 1) pathological findings that matched scan indication, 2) known organ specific disease and/or incidental findings confirmed on other scan modality prior to SSTR PET/CT, 3) lack of diagnosis and/or follow up, and 4) results published in proceedings or conference abstracts. Results Twenty-one studies, comprising a total of 2906 subjects, were eligible for the analysis. Studies included were retrospective cohort studies on incidental SSTR PET/CT findings in a specific organ (n = 2888, 7/21) or case reports (n = 18, 14/21). A total of 133 subjects had incidental SSTR PET/CT findings. Incidental findings were predominantly seen in the thyroid gland (n = 65), spine (n = 30), brain (n = 26) and breast (n = 6). Seventeen of 133 (13%) incidental findings were malignant on final diagnosis. Incidental breast findings were associated with the highest risk of malignancy (67%). In the thyroid, incidental SSTR uptake was caused by malignancy in 8%, all presenting as focal uptake. The lowest risk was seen in the spine with a malignancy rate of 3% in patients with incidental SSTR uptake and benign cases were interpreted as vertebral hemangiomas on CT. Incidental SSTR PET/CT findings in other locations were of malignant etiology in two out of six cases (33%) and should be evaluated individually. Conclusion The most incidental SSTR PET/CT findings were found in the thyroid gland, spine, and brain. The risk of malignancy was greatest in incidental SSTR PET/CT findings in the breast, cranially, and thyroid gland. The results of the present study can prove useful in the interpretation of atypical findings on SSTR PET/CT and in the counseling of clinicians.

show abstract

Incidental Detection of Retiform Hemangioendothelioma by 68Ga DOTATOC PET/CT

Cited by 6 publications

References 9 publications

Metastatic Esophageal Adenocarcinoma Showing 68Ga-DOTATATE Uptake

Metastatic Esophageal Adenocarcinoma Showing 68Ga-DOTATATE Uptake

Retiform hemangioendothelioma: a rare lesion of the vulva

Prevalence and significance of incidental findings on 68 Ga-DOTA-conjugated somatostatin receptor-targeting peptide PET/CT: a systematic review of the literature

Contact Info

Product

Resources

About