Incidental Enchondromas of the Knee

Walden, Michael J.; Murphey, Mark D.; Vidal, Jorge A.

doi:10.2214/ajr.07.2796

Cited by 106 publications

(78 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The prevalence of incidentally found enchondromas in the present study (3.3%) was, therefore, compatible with data in the literature. In the present study, the prevalence of enchondromas in the distal femur (2.4%) was slightly higher than the prevalence observed by Walden et al (13) . Enchondromas may also be incidentally found with a relative frequency at routine shoulder studies (2.1%), in most of times located in the contiguous region of the physis (26) .…”

Section: Discussioncontrasting

confidence: 81%

“…According to Walden et al, the prevalence of incidentally found enchondromas at knee MRI was of 2.9%, most of times located in the distal femur (2.0%) (13) . In the study of Walden et al, the prevalence of lesions in the distal tibia corresponded to 0.7%, and 0.2% in the fibula.…”

Section: Discussionmentioning

confidence: 99%

“…The criteria adopted by the radiologists to diagnose an incidental enchondroma by MRI were the same used in the study developed by Walden et al (13) . It were considered incidental enchondromas bone marrow focal changes that met the following criteria: focal geographic areas of bone marrow replacement on T1-weighted images, and with high signal intensity on fluid-sensitive images with fat suppression, and lobulated contours on both T1 and intermediate weightings.…”

Section: Methodsmentioning

confidence: 99%

“…It is the second most common benign bone neoplasia just after osteochondroma. It is believed that enchondromas represent 12% to 24% of all benign bone tumors and 3% to 10% of all bone tumors (13) .…”

Section: Introductionmentioning

confidence: 99%

“…In the study developed by Walden et al, 449 consecutive routine knee MRI studies were evaluated, and the authors observed the prevalence of incidental enchondromas in 2.9% of the images (13) . Such authors suggest that the recognition of incidental enchondromas is important to avoid confusion with other diseases.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Incidental enchondromas at knee magnetic resonance imaging: intraobserver and interobserver agreement and prevalence of imaging findings

et al. 2013

View full text Add to dashboard Cite

Objective: To evaluate intra-and interobserver agreement in the identification of incidental enchondromas at knee magnetic resonance imaging, and to assess the prevalence of imaging findings. Materials and Methods: Retrospective study reviewing 326 knee magnetic resonance images acquired in the period between November 2009 and September 2010. The images were independently and blindly analyzed by two specialists in musculoskeletal radiology, with the objective of identifying incidental enchondromas, presence of foci with signal similar to bone marrow and foci of signal absence suggestive of calcifications within the enchondromas. Inter-and intraobserver agreements were analyzed. Results: Eleven lesions compatible with enchondromas (3.3%) were identified. The interobserver agreement for the presence of enchondroma was high. Prevalence of foci of bone marrow signal inside the enchondromas was of 54.55%, and foci suggestive of calcification corresponded to 36.36%. The intraobserver agreement for foci of bone marrow signal in enchondromas was perfect, and interobserver agreement was high. Conclusion: The prevalence of incidental enchondromas in the current study was compatible with data in the literature. Excellent agreement was observed in the identification of enchondromas and in the assessment of imaging findings. A higher prevalence of fat signal foci was observed as compared with signal absence suggestive of calcifications. Keywords: Enchondromas; Magnetic resonance imaging; Knee; Bone marrow.Objetivo: Avaliar a confiabilidade intra e interobservador na identificação de encondromas incidentais na ressonância magnética de joelho e estudar a prevalência das características de imagens destas lesões. Materiais e Métodos: Estudo retrospectivo, com revisão de 326 ressonâncias magnéticas do joelho realizadas entre novembro de 2009 e setembro de 2010. As imagens foram analisadas por dois médicos especialistas em radiologia musculoesquelética, de forma independente e às cegas, visando a identificar encondromas incidentais, presença de focos com sinal semelhante à medula óssea e focos de ausência de sinal sugestivos de calcificações no interior dos encondromas. Foram realizadas análises das concordâncias inter e intraobservador. Resultados: Foram identificadas 11 lesões compatíveis com encondromas (3,3%). A concordância interobservador para presença de encondroma foi alta. A prevalência de focos de sinal de medula óssea no interior dos encondromas foi 54,55% e de focos sugestivos de calcificação foi 36,36%. A concordância intraobservador para focos de sinal de medula óssea nos encondromas foi perfeita, e a concordância interobservador foi alta. Conclusão: A prevalência de encondromas incidentais no trabalho atual foi consistente com a literatura. Foi observada excelente concordância no estudo de confiabilidade da identificação de encondromas e de suas características, notando-se maior prevalência de focos com sinal de gordura do que de calcificações. Unitermos: Encondromas; Ressonância magnética; Joelho; Medula óssea. Ab...

show abstract

Section: Discussioncontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Incidental enchondromas at knee magnetic resonance imaging: intraobserver and interobserver agreement and prevalence of imaging findings

et al. 2013

View full text Add to dashboard Cite

show abstract

Distinct Roles of Glutamine Metabolism in Benign and Malignant Cartilage Tumors With IDH Mutations

Zhang

Puviindran

Nadesan

et al. 2020

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Enchondromas and chondrosarcomas are common cartilage neoplasms that are either benign or malignant, respectively. The majority of these tumors harbor mutations in either IDH1 or IDH2. Glutamine metabolism has been implicated as a critical regulator of tumors with IDH mutations. Using genetic and pharmacological approaches, we demonstrated that glutaminase‐mediated glutamine metabolism played distinct roles in enchondromas and chondrosarcomas with IDH1 or IDH2 mutations. Glutamine affected cell differentiation and viability in these tumors differently through different downstream metabolites. During murine enchondroma‐like lesion development, glutamine‐derived α‐ketoglutarate promoted hypertrophic chondrocyte differentiation and regulated chondrocyte proliferation. Deletion of glutaminase in chondrocytes with Idh1 mutation increased the number and size of enchondroma‐like lesions. In contrast, pharmacological inhibition of glutaminase in chondrosarcoma xenografts reduced overall tumor burden partially because glutamine‐derived non‐essential amino acids played an important role in preventing cell apoptosis. This study demonstrates that glutamine metabolism plays different roles in tumor initiation and cancer maintenance. Supplementation of α‐ketoglutarate and inhibiting GLS may provide a therapeutic approach to suppress enchondroma and chondrosarcoma tumor growth, respectively. © 2022 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

show abstract

Machine learning and magnetic resonance imaging: Differentiating benign from malignant osseous tumors

Emil

Sibbitt²,

Sibbitt

2023

J of Clinical Ultrasound

View full text Add to dashboard Cite

show abstract

Incidental Enchondromas of the Knee

Cited by 106 publications

References 7 publications

Incidental enchondromas at knee magnetic resonance imaging: intraobserver and interobserver agreement and prevalence of imaging findings

Incidental enchondromas at knee magnetic resonance imaging: intraobserver and interobserver agreement and prevalence of imaging findings

Distinct Roles of Glutamine Metabolism in Benign and Malignant Cartilage Tumors With IDH Mutations

Machine learning and magnetic resonance imaging: Differentiating benign from malignant osseous tumors

Contact Info

Product

Resources

About