Incidental finding of malignancy in patients preoperatively evaluated for aneurysm wall pathology using PET/CT

Truijers, Maarten; Pol, Jillis A.; Kurvers, H. A. J. M.; Bredie, S.J.H.; Oyen, Wim J.G.; Blankensteijn, Jan D.

doi:10.1016/j.jvs.2008.12.001

Cited by 13 publications

(6 citation statements)

References 10 publications

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“…Incidental findings are routinely identified on virtually all types of imaging studies [10,[16][17][18][19][20][21][22]. In particular, MRI and CT-as highresolution cross-sectional modalities-often reveal unsuspected abnormalities or variants outside of the target organs of interest.…”

Section: Discussionmentioning

confidence: 99%

The Prevalence and Clinical Significance of Noncardiac Findings on Cardiac MRI

Atalay

Prince

Pearson

et al. 2011

American Journal of Roentgenology

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Section: Discussionmentioning

confidence: 99%

The Prevalence and Clinical Significance of Noncardiac Findings on Cardiac MRI

Atalay

Prince

Pearson

et al. 2011

American Journal of Roentgenology

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“…smokers) or even asymptomatic persons not at risk, PET/CT is probably most sensitive in the detection of malignancies [25, 29, 51, 52]. This is supported by the fact that PET/CT is used if not primarily at least as ultima ratio to find the primary cancer in patients with CUP syndrome [53].…”

Section: Discussionmentioning

confidence: 99%

Detection of relevant colonic neoplasms with PET/CT: promising accuracy with minimal CT dose and a standardised PET cut-off

et al. 2010

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Objective:To determine the performance of FDG-PET/CT in the detection of relevant colorectal neoplasms (adenomas ≥10 mm, with high-grade dysplasia, cancer) in relation to CT dose and contrast administration and to find a PET cut-off.Methods:84 patients, who underwent PET/CT and colonoscopy (n = 79)/sigmoidoscopy (n = 5) for colonic segments, were included in a retrospective study. The accuracy of low-dose PET/CT in detecting mass-positive segments was evaluated by ROC analysis by two blinded independent reviewers relative to contrast-enhanced PET/CT. On a per-lesion basis characteristic PET values were tested as cut-offs.Results:Low-dose PET/CT and contrast-enhanced PET/CT provide similar accuracies (area under the curve for the average ROC ratings 0.925 vs. 0.929, respectively). PET demonstrated all carcinomas (n = 23) and 83% (30/36) of relevant adenomas. In all carcinomas and adenomas with high-grade dysplasia (n = 10) the SUVmax was ≥5. This cut-off resulted in a better per-segment sensitivity and negative predictive value (NPV) than the average PET/CT reviews (sensitivity: 89% vs. 82%; NPV: 99% vs. 98%). All other tested cut-offs were inferior to the SUVmax.Conclusion:FDG-PET/CT provides promising accuracy for colorectal mass detection. Low dose and lack of iodine contrast in the CT component do not impact the accuracy. The PET cut-off SUVmax ≥ 5 improves the accuracy.

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“…Researchers have also tried to correlate FDG uptake with aneurysm rupture risk in humans; however, quantifying this relationship has proven to be nontrivial [140]. In another study, FDG was used with PET/CT to investigate aneurysm wall pathology and coincidentally identified concomitant tumors in several patients [141]. This discovery illustrates the diversity of applications for PET/CT.…”

Section: Molecular and Functional Imagingmentioning

confidence: 99%

Molecular Imaging of Experimental Abdominal Aortic Aneurysms

Ramaswamy

Hamilton

Joshi

et al. 2013

The Scientific World Journal

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Current laboratory research in the field of abdominal aortic aneurysm (AAA) disease often utilizes small animal experimental models induced by genetic manipulation or chemical application. This has led to the use and development of multiple high-resolution molecular imaging modalities capable of tracking disease progression, quantifying the role of inflammation, and evaluating the effects of potential therapeutics. In vivo imaging reduces the number of research animals used, provides molecular and cellular information, and allows for longitudinal studies, a necessity when tracking vessel expansion in a single animal. This review outlines developments of both established and emerging molecular imaging techniques used to study AAA disease. Beyond the typical modalities used for anatomical imaging, which include ultrasound (US) and computed tomography (CT), previous molecular imaging efforts have used magnetic resonance (MR), near-infrared fluorescence (NIRF), bioluminescence, single-photon emission computed tomography (SPECT), and positron emission tomography (PET). Mouse and rat AAA models will hopefully provide insight into potential disease mechanisms, and the development of advanced molecular imaging techniques, if clinically useful, may have translational potential. These efforts could help improve the management of aneurysms and better evaluate the therapeutic potential of new treatments for human AAA disease.

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Incidental finding of malignancy in patients preoperatively evaluated for aneurysm wall pathology using PET/CT

Cited by 13 publications

References 10 publications

The Prevalence and Clinical Significance of Noncardiac Findings on Cardiac MRI

The Prevalence and Clinical Significance of Noncardiac Findings on Cardiac MRI

Detection of relevant colonic neoplasms with PET/CT: promising accuracy with minimal CT dose and a standardised PET cut-off

Molecular Imaging of Experimental Abdominal Aortic Aneurysms

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