Incidental Finding of Placental Choriocarcinoma After an Uncomplicated Term Pregnancy

Ganapathi, Karthik A.; Paczos, Tamera; George, Mary D.; Goodloe, Samuel; Balos, Lucia; Chen, Fanglin

doi:10.1097/pgp.0b013e3181d81cc2

Cited by 35 publications

(21 citation statements)

References 9 publications

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“…In the literature there are case reports of choriocarcinoma presenting in a normal viable pregnancy. This is often an incidental finding from placental histology after uncomplicated deliveries 6 . There are also case reports of choriocarcinoma presenting with metastases 7–10 .…”

Section: Discussionmentioning

confidence: 98%

“…Choriocarcinoma is usually preceded by a complete mole, ectopic pregnancy, non‐molar intrauterine abortion and, uncommonly, by a partial mole. Choriocarcinoma coexisting with or after an otherwise normal, viable pregnancy is extremely rare, with an estimated occurrence of 1 per 160 000 pregnancies 6 . Metastases from this tumour may present in a variety of ways depending on the site and can be fatal.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Metastatic choriocarcinoma presenting and treated during viable pregnancy: a case report

Bircher

Smith

Seckl

et al. 2011

BJOG: An International Journal of Obstetrics &Amp; Gynaecology

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We present a 25-year-old Caucasian woman in her first pregnancy (conceived on clomiphene) who had an uncomplicated course until 19 weeks of pregnancy. She has given written permission for the case to be reported. Booking blood tests in 2003 showed her to be blood group A positive and negative for hepatitis B virus and HIV. A nuchal translucency scan was low risk and confirmed the gestational age. She had a past history of ileo-caecal resection for Crohn's disease 4 years earlier.Between 19 and 23 weeks of gestation she had recurrent episodes of abdominal pain and vaginal bleeding warranting admission and a 2-unit blood transfusion. At 22 weeks an ultrasound scan showed normal fetal anatomy and a normal posterior, not low, placenta. However, it showed an 8.5-cm complex cystic mass on the anterior uterine wall. This was felt likely to represent a blood clot because it had not been present on the routine anomaly scan at 20 weeks. She remained an inpatient as she continued to have intermittent vaginal bleeding.After 6 days she complained of breathlessness and pleuritic chest pain. An ECG showed sinus tachycardia and a chest X-ray showed multiple rounded opacities throughout both lungs, measuring up to 2 cm in diameter, suggestive of metastases. A subsequent computed tomography pulmonary angiogram showed no evidence of embolic disease but confirmed multiple lesions highly suggestive of metastases. Renal, liver and thyroid function were normal and a quantitative b-human chorionic gonadotrophin (bhCG) measurement was 115 000 IU/l. Clinical examination of the breasts and skin revealed no abnormality and there were no palpable lymph nodes in the neck, groin and axilla.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Metastatic choriocarcinoma presenting and treated during viable pregnancy: a case report

Bircher

Smith

Seckl

et al. 2011

BJOG: An International Journal of Obstetrics &Amp; Gynaecology

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“…Choriocarcinoma coexisting with or after a 'normal' pregnancy has an incidence of 1 per 160,000 pregnancies [30]. It is associated with poor prognosis and rapid spreading of fatal disease; however, it is curable if diagnosed early and treated accordingly [31,32].…”

Section: Choriocarcinomamentioning

confidence: 99%

Chemotherapy during Pregnancy: Cases of Hodgkin's and Non-Hodgkin's Lymphoma, Chronic Myeloid Leukemia, Breast Cancer, Nasopharyngeal Cancer, and Choriocarcinoma

et al. 2017

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Background: The use of chemotherapeutics during pregnancy is a dilemma for both the patient and the clinician. We report here our 11 years' experience with the use of chemotherapy during pregnancy. Patients: 13 patients undergoing chemotherapy during their current pregnancy were evaluated. The medical data of 5 patients with hematologic malignancies (2 Hodgkin's, 2 non-Hodgkin's lymphoma, and 1 chronic myeloid leukemia), 6 patients with breast cancer, 1 patients with nasopharyngeal cancer, and 1 patient with choriocarcinoma were retrospectively obtained from the ‘perinatal database' of Hacettepe University for the period of January 2002 through March 2016. Results: 4 patients had a medical termination due to teratologic effects. 4 patients had a vaginal delivery, and 5 patients delivered by caesarean section. The 9 newborns who had been exposed to chemotherapeutics were free of congenital anomalies. However, 1 of them died in the early neonatal period due to multi-organ failure (nasopharyngeal cancer). During the 2-year follow-up, we encountered 1 maternal mortality, which was due to multi-organ failure in a non-Hodgkin's lymphoma patient. Conclusion: Physicians must pay attention to potential teratologic problems, and should carefully balance maternal and fetal risks. Selected chemotherapeutic agents can be given in the 2nd and 3rd trimester without any major teratogenic risk. All 9 newborns in our study were free of anomalies, although 1 of them died in the neonatal period.

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“…Choriocarcinoma coexisting with or after an otherwise "normal" pregnancy is extremely rare, with an estimated occurrence of 1 per 160,000 pregnancies 1 . Choriocarcinoma is frequently preceded by a complete mole, ectopic pregnancy, nonmolar intrauterine abortion, and uncommonly by a partial mole 1 Gestational choriocarcinoma is a highly malignant tumor of trophoblastic cells with a propensity to metastasize to various sites 2 .…”

Section: Introductionmentioning

confidence: 99%

“…Choriocarcinoma is frequently preceded by a complete mole, ectopic pregnancy, nonmolar intrauterine abortion, and uncommonly by a partial mole 1 Gestational choriocarcinoma is a highly malignant tumor of trophoblastic cells with a propensity to metastasize to various sites 2 . Choriocarcinoma invades and metastasis early and is often widespread at the time of diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Unusual Presentation of Choriocarcinoma Six Months after Term Delivery: A Case Report

2016

IJSR

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Choriocarcinoma coexisting with or after an otherwise normal pregnancy is extremely rare. Choriocarcinoma invades and metastasis early and is often widespread at the time of diagnosis. A 25 year old female complaining of bleeding p/v since 1 month with spontaneous expulsion of a mass per vaginum, after post partal amenorrhoea of 5 months. A history of contact was present. In this case, the diagnosis was established by histopathological examination of expelled tissue mass. Adequate tissue samples are necessary for histopathological diagnosis and early diagnosis of gestational choriocarcinoma can be done by routine histopathological examination of the placenta after birth.

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Incidental Finding of Placental Choriocarcinoma After an Uncomplicated Term Pregnancy

Cited by 35 publications

References 9 publications

Metastatic choriocarcinoma presenting and treated during viable pregnancy: a case report

Metastatic choriocarcinoma presenting and treated during viable pregnancy: a case report

Chemotherapy during Pregnancy: Cases of Hodgkin's and Non-Hodgkin's Lymphoma, Chronic Myeloid Leukemia, Breast Cancer, Nasopharyngeal Cancer, and Choriocarcinoma

Unusual Presentation of Choriocarcinoma Six Months after Term Delivery: A Case Report

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