Incidental Findings Suggestive of COVID-19 Pneumonia in Oncologic Patients Undergoing <sup>18</sup>F-FDG PET/CT Studies: Association Between Metabolic and Structural Lung Changes

Wakfie-Corieh, Cristina Gamila; Ferrando-Castagnetto, Federico; García, Alba María Blanes; García-Esquinas, M. García; Candil, A. Ortega; Rey, Cristina Rodríguez; Martín, María Nieves Cabrera; Cano, Ana Delgado; Delgado, José Luis Carreras

doi:10.2967/jnumed.121.261915

Cited by 10 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increase of FDG uptake in lung lesions with time indicates increasing lung inflammation in the acute stage of COVID-19 infection. COVID-19 Reporting and Data System (CO-RADS) criteria applied to CT findings showed a relation to FDG uptake (SUV max ) in the lung parenchyma in asymptomatic cancer patients ( 45 ). Thornton et al ( 46 ) showed that a lung target-to-background ratio (TBRlung [SUV max /SUV min ]) was strongly correlated with time after infection within 3 weeks after infection, and was higher in the late stage of COVID-19 infection (>1 week to ≤4 weeks after disease onset) than those in the early stage (approximately ≤ 1 week after disease onset) (TBRlung 6.4 vs. 13.7).…”

Section: F-fluorodeoxyglucose Positron Emission Tomography/computed T...mentioning

confidence: 99%

Oncology and cardiology positron emission tomography/computed tomography faced with COVID-19: A review of available literature data

Minamimoto

2022

Front. Med.

View full text Add to dashboard Cite

The COVID-19 pandemic has forced people to significantly change their lifestyles and attitudes, and has greatly burdened healthcare delivery systems worldwide. The redistribution of the medical delivery system to maintain normal medical care while responding generously to COVID-19 is a continuing challenge that weighs heavily on medical institutions. Among imaging modalities, chest X-rays and computed tomography (CT) examinations have clearly made a large contribution to treatment of COVID-19. In contrast, it is difficult to express the standpoint of nuclear medicine examinations in a straightforward manner, as the greatest emphasis in this modality has been on how necessary medical care can continue to be provided. Many clinical reports of nuclear medicine examinations related to COVID-19 have been published, and knowledge continues to accumulate. This review provides a summary of the current state of oncology and cardiology positron emission tomography (PET) examinations related to COVID-19, and includes preparation of the nuclear medicine department, trends in PET examinations, specific imaging findings on 18F-fluorodeoxyglucose (FDG) PET/CT, imaging of complications of COVID-19, PET tracers other than FDG, and the effects of vaccines on PET imaging findings.

show abstract

Section: F-fluorodeoxyglucose Positron Emission Tomography/computed T...mentioning

confidence: 99%

Oncology and cardiology positron emission tomography/computed tomography faced with COVID-19: A review of available literature data

Minamimoto

2022

Front. Med.

View full text Add to dashboard Cite

show abstract

“…Several studies indicated a 2- to 4-fold increased incidence of interstitial pneumonia detected on 18 F-FDG PET/CT in the latter group during the early phase of the pandemic ( 5 ). Other authors identified a relationship between the structural changes as assessed using the COVID-19 Reporting and Data System and metabolic changes ( 6 ). Albeit informative, such reports did not take into account the temporal kinetics of the disease.…”

mentioning

confidence: 99%

Imaging in Post-COVID Lung Disease: Does ¹⁸F-FDG PET/CT Have the Key?

2021

View full text Add to dashboard Cite

Diagnostic performance of CO-RADS for COVID-19: a systematic review and meta-analysis

Liu

Chen

et al. 2022

Eur Radiol

View full text Add to dashboard Cite

Objectives To investigate the diagnostic performance of the coronavirus disease 2019 (COVID-19) Reporting and Data System (CO-RADS) for detecting COVID-19. Methods We searched PubMed, EMBASE, MEDLINE, Web of Science, Cochrane Library, and Scopus database until September 21, 2021. Statistical analysis included data pooling, forest plot construction, heterogeneity testing, meta-regression, and subgroup analyses. Results We included 24 studies with 8382 patients. The pooled sensitivity and specificity and the area under the curve (AUC) of CO-RADS ≥ 3 for detecting COVID-19 were 0.89 (95% confidence interval (CI) 0.85–0.93), 0.68 (95% CI 0.60–0.75), and 0.87 (95% CI 0.84–0.90), respectively. The pooled sensitivity and specificity and AUC of CO-RADS ≥ 4 were 0.83 (95% CI 0.79–0.87), 0.84 (95% CI 0.78–0.88), and 0.90 (95% CI 0.87–0.92), respectively. Cochran’s Q test ( p < 0.01) and Higgins I 2 heterogeneity index revealed considerable heterogeneity. Studies with both symptomatic and asymptomatic patients had higher specificity than those with only symptomatic patients using CO-RADS ≥ 3 and CO-RADS ≥ 4. Using CO-RADS ≥ 4, studies with participants aged < 60 years had higher sensitivity (0.88 vs. 0.80, p = 0.02) and lower specificity (0.77 vs. 0.87, p = 0.01) than studies with participants aged > 60 years. Conclusions CO-RADS has favorable performance in detecting COVID-19. CO-RADS ≥ 3/4 might be applied as cutoff values given their high sensitivity and specificity. However, there is a need for more well-designed studies on CO-RADS. Key Points • CO-RADS shows a favorable performance in detecting COVID-19. • CO-RADS ≥ 3 had a high sensitivity 0.89 (95% CI 0.85–0.93), and it may prove advantageous in screening the potentially infected people to prevent the spread of COVID-19. • CO-RADS ≥ 4 had high specificity 0.84 (95% CI 0.78–0.88) and may be more suitable for definite diagnosis of COVID-19.

show abstract

Incidental Findings Suggestive of COVID-19 Pneumonia in Oncologic Patients Undergoing ¹⁸F-FDG PET/CT Studies: Association Between Metabolic and Structural Lung Changes

Abstract: Incidental findings suggestive of COVID-19 pneumonia in oncological patients undergoing 18 F-FDG PET/CT studies: association between metabolic and structural lung changes. Short title. PET and CT lung changes on COVID-19.

Cited by 10 publications

References 30 publications

Oncology and cardiology positron emission tomography/computed tomography faced with COVID-19: A review of available literature data

Oncology and cardiology positron emission tomography/computed tomography faced with COVID-19: A review of available literature data

Imaging in Post-COVID Lung Disease: Does ¹⁸F-FDG PET/CT Have the Key?

Diagnostic performance of CO-RADS for COVID-19: a systematic review and meta-analysis

Contact Info

Product

Resources

About

Incidental Findings Suggestive of COVID-19 Pneumonia in Oncologic Patients Undergoing 18F-FDG PET/CT Studies: Association Between Metabolic and Structural Lung Changes

Abstract: Incidental findings suggestive of COVID-19 pneumonia in oncological patients undergoing 18 F-FDG PET/CT studies: association between metabolic and structural lung changes. Short title. PET and CT lung changes on COVID-19.

Cited by 10 publications

References 30 publications

Oncology and cardiology positron emission tomography/computed tomography faced with COVID-19: A review of available literature data

Oncology and cardiology positron emission tomography/computed tomography faced with COVID-19: A review of available literature data

Imaging in Post-COVID Lung Disease: Does 18F-FDG PET/CT Have the Key?

Diagnostic performance of CO-RADS for COVID-19: a systematic review and meta-analysis

Contact Info

Product

Resources

About

Incidental Findings Suggestive of COVID-19 Pneumonia in Oncologic Patients Undergoing ¹⁸F-FDG PET/CT Studies: Association Between Metabolic and Structural Lung Changes

Imaging in Post-COVID Lung Disease: Does ¹⁸F-FDG PET/CT Have the Key?