Incidental folliculotropic mycosis fungoides in a blepharoplasty specimen performed for dermatochalasis

Mudhar, Hardeep Singh; Tiffin, Nick; Currie, Zanna; Salvi, Sachin M.

doi:10.1038/eye.2013.297

Cited by 4 publications

(5 citation statements)

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“…Furthermore, the two patients (patients 1, 6) with biopsies failing to show classical features of FMF exhibited clinical features. The first reported case of FMF affecting the periorbital area was a 68-year-old woman, diagnosed after blepharoplasty (13). Patients suffering from FMF also tend to have a worse prognosis than patients with classical MF.…”

Section: Discussionmentioning

confidence: 99%

Periorbital Involvement in Early Stage Mycosis Fungoides

et al. 2017

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Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphomas (CTCL) and accounts for approximately 50% of all CTCL (1, 2). Classically, it presents with erythematous patches on sun-protected areas 2-10 years before confirmed on skin biopsy (3). Approximately 10% of patients initially presenting with patches will subsequently progress to advanced stages of disease (4). Since its first description, MF continues to evolve with discovering of new variants (2). Periorbital involvement is a rare finding in MF and is usually associated with advanced stages of disease. In 1892, Besnier & Hallopeau reported the first patient with periorbital involvement, and extensive and ultimately, fatal disease (5). While the majority of cases describe patients with advanced stages, to date only few reports of isolated periorbital involvement, in early stage MF have been published (6-11). Herein, we report the clinical, epidemiological and histopathological presentation of 7 patients with biopsy proven early stage MF and periorbital lesions. PATIENTS AND METHODS We conducted a retrospective study of patients seen with periorbital MF lesions, at the CTCL clinic at the MD Anderson Cancer Center, Houston Texas. The study protocol was approved by the institutional review board (#PA16-0091). Additional informed consent was obtained from all individual participants for whom identifying information is included in this article. Electronic medical records and paper-based flow charts were screened for patients with periorbital involvement in MF. Clinical and histopathological data were re-evaluated. Diagnosis and staging of MF were made by a CTCL expert (M.D), according to the modified International Society of Cutaneous Lymphomas/European Organization for Research and Treatment of Cancer revisions of the TNMB Classification of MF and Sézary syndrome (1). All analyses were conducted using SPSS version 22.0 (IBM Corporation, Armonk, NY, USA). Continuous data are expressed as mean ± standard deviation (SD) and median (range), as appropriate. Basic summary statistics were used to describe demographic data, treatment modalities, and response.

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Section: Discussionmentioning

confidence: 99%

Periorbital Involvement in Early Stage Mycosis Fungoides

et al. 2017

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“…10,24 Various periocular clinical features of FMF have been described and marked swelling or diffuse thickening on eyelids (Figure 2a) usually with loss of eyelashes (madarosis) was considered a typical presentation for this type. 9,10,20 Most of the FMF patients show erythematous patches and plaques on eyelids 1d, 2b,c) indistinguishable from lesions in patients with classical MF on other sites, whereas more typical FMF lesions such as eczematization (Figures 2d and 3a), excoriations (Figure 3a) and milia-like papules (Figure 3b,c) could also be encountered. 10 Ectropion is a typical feature of erythrodermic MF and Sezary syndrome 9 but may also be seen in FMF patients (Figure 3c,d).…”

Section: Mycosis Fungoidesmentioning

confidence: 97%

“…Eyelid lesions of MF are usually diagnosed clinically and biopsy may not be required from this localization, as patients with eyelid involvement have mostly been previously diagnosed with MF from lesions of other areas 3,10,15 . However, isolated lesions of the eyelid as an initial manifestation or recurrence sign of MF have also been described 18–20 . The reported clinical presentation of eyelid involvement of MF is quite variable 3,4,10,15–17 .…”

Section: Mycosis Fungoidesmentioning

confidence: 99%

“…In most of the FMF patients with eyelid involvement, other areas of the face or the body are involved but unilesional FMF of the eyelid is also reported 10,24 . Various periocular clinical features of FMF have been described and marked swelling or diffuse thickening on eyelids (Figure 2a) usually with loss of eyelashes (madarosis) was considered a typical presentation for this type 9,10,20 . Most of the FMF patients show erythematous patches and plaques on eyelids (Figure 1d, 2b,c) indistinguishable from lesions in patients with classical MF on other sites, whereas more typical FMF lesions such as eczematization (Figures 2d and 3a), excoriations (Figure 3a) and milia‐like papules (Figure 3b,c) could also be encountered 10 .…”

Section: Mycosis Fungoidesmentioning

confidence: 99%

“…3,10,15 However, isolated lesions of the eyelid as an initial manifestation or recurrence sign of MF have also been described. [18][19][20] The reported clinical presentation of eyelid involvement of MF is quite variable. 3,4,10,[15][16][17] In most reports detailed information of patients regarding stage and MF subtypes were not mentioned.…”

Section: Mycosis Fungoidesmentioning

confidence: 99%

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Eyelid involvement of primary cutaneous lymphomas: A clinical perspective

Baykal

Atci

2023

Aust J Dermatology

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Eyelids may be affected in systemic, ocular adnexal and primary cutaneous lymphomas (PCLs). The frequency of eyelid involvement in PCLs is still not well known and it is not a predilection site for any type. While primary cutaneous T‐cell lymphomas (CTCLs) are more commonly seen than primary cutaneous B‐cell lymphomas (CBCLs), especially mycosis fungoides (MF) as by far the most frequent type, B cell lymphomas are reported to be the commonest type in eyelid localization on the contrary. PCLs may be located on the eyelids, as the sole manifestation or in association with the involvement of other parts of the eye and elsewhere of the body. MF may present with a rich spectrum of clinical features on the eyelids mostly seen in folliculotropic subtype and advanced‐stage disease. Erythematous scaly patches or plaques representing the most commonly encountered eyelid MF lesions may mimic many other dermatological conditions. Diffuse thickening, oedema, poikilodermic changes, atrophy and wrinkling are other suggestive findings of eyelid MF. Milia‐like papules, madarosis and ectropion are also seen in the folliculotropic variant of MF, as ectropion is more typical for Sezary syndrome. Eyelids are also a typical location for tumoural MF which has been suggested as a poor prognostic indicator in MF. Papulonodular lesions, large tumours, ulceration, diffuse infiltration, oedema and subcutaneous atrophy on the eyelids may also be seen in other types of PCLs. Keep in mind, the rich clinical spectrum of PCLs on the eyelids may be crucial in early diagnosis in this special localization.

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Primary cutaneous extranodal marginal zone B-cell lymphoma of the eyelid skin: Diagnostic clues and distinction from other ocular adnexal diseases

Stagner

Freitag

2016

Survey of Ophthalmology

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Incidental folliculotropic mycosis fungoides in a blepharoplasty specimen performed for dermatochalasis

Cited by 4 publications

References 5 publications

Periorbital Involvement in Early Stage Mycosis Fungoides

Periorbital Involvement in Early Stage Mycosis Fungoides

Eyelid involvement of primary cutaneous lymphomas: A clinical perspective

Primary cutaneous extranodal marginal zone B-cell lymphoma of the eyelid skin: Diagnostic clues and distinction from other ocular adnexal diseases

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