Incidental Lewy body disease: Clinical comparison to a control cohort

Abstract

Limited clinical information has been published on cases pathologically diagnosed with incidental Lewy body disease (ILBD). Standardized, longitudinal movement and cognitive data was collected on a cohort of subjects enrolled in the Sun Health Research Institute Brain and Body Donation Program. Of 277 autopsied subjects who had antemortem clinical evaluations within the previous 3 years, 76 did not have Parkinson’s disease, a related disorder, or dementia of which 15 (20%) had ILBD. Minor extrapyramidal signs were common in subjects with and without ILBD. Cognitive testing revealed an abnormality in the ILBD group in the Trails B test only. ILBD cases had olfactory dysfunction; however, sample size was very small. This preliminary report revealed ILBD cases have movement and cognitive findings that for the most part were not out of proportion to similarly assessed and age-similar cases without Lewy bodies. Larger sample size is needed to have the power to better assess group differences.

Prevalence of impaired odor identification in Parkinson disease with imaging evidence of nigrostriatal denervation

“…This may represent a significant confounding factor as the prevalence of incidental prodromal Alzheimer and Lewy body neurodegenerative pathology in cognitively normal elderly has been reported as high as 44% and 20%, respectively. Such presence of prodromal neurodegenerative pathology, frequently found in otherwise normal elderly subjects, may negatively affect olfaction (Adler et al 2010; Jansen et al 2015). Consequently, inclusion of non-screened elderly subjects with prodromal neurodegeneration in normative databases may artificially lower age-dependent hyposmia cutoffs.…”

Peripheral Lewy body pathology in Parkinson's disease and incidental Lewy body disease: Four cases

“…The focus has also shifted to the analysis of patients without motor PD in whom LP are found at autopsy, i.e., incidental Lewy body disease (ILBD) [5,[16][17][18][19][20][21]. In this study, we report on the presence of LP in the autonomic nervous system of three PD cases and one ILBD case using alpha-synuclein immunohistochemistry in 100 μm thick tissue sections to visualize the morphology of LP.…”

The Montreal Cognitive Assessment and the Mini-Mental State Examination as Screening Instruments for Cognitive Impairment: Item Analyses and Threshold Scores

“…Details of the evaluation have been described elsewhere [17,18]. A nearly consecutive sample of subjects were administered the MoCA by a single physician (S.A.J.…”