Incidental littoral cell angioma of the spleen

Tee, May C.; Vos, Patrick M.; Zetler, Peter; Wiseman, Sam M.

doi:10.1186/1477-7819-6-87

Cited by 26 publications

(29 citation statements)

References 33 publications

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“…Symptomatic LCA is often treated by splenectomy, given that several case reports have identified its malignant potential [22,23]. Bearing in mind the immunological disorders which may follow a pediatric splenectomy (as in our first case), the additional spleens which were present in that particular child were left intact.…”

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confidence: 99%

Is littoral cell angioma of the spleen as rare as previously believed in the pediatric population?

Matuszczak¹,

Reszeć²,

Dębek³

et al. 2012

Folia Histochem Cytobiol.

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Littoral cell angioma (LCA) is a rare primary splenic vascular tumor, originating from the littoral cells lining the red pulp sinuses of the spleen. There are only a handful of case reports of LCA in children to be found in the literature. We performed a retrospective analysis of the medical charts of pediatric patients with splenic lesions who were treated between 2005 and 2010 in the Pediatric Surgery Department of the Medical University of Bialystok. Surprisingly, LCA accounted for 37.5% of the splenic lesions found in our series. The majority of LCA tumors are benign, but given their malignant potential, splenectomy and long-term follow-up should be the gold standard for their management. We strongly support the use of further cross-sectional studies to properly elucidate the prevalence of littoral cell angioma of the spleen in the pediatric population. (Folia Histochemica et Cytobiologica 2012, Vol. 50, No. 3, 480-485)

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confidence: 99%

Is littoral cell angioma of the spleen as rare as previously believed in the pediatric population?

Matuszczak¹,

Reszeć²,

Dębek³

et al. 2012

Folia Histochem Cytobiol.

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“…5,6 Desde la década de 1930, las células endoteliales que recubren los senos vasculares del bazo se consideraron únicas debido a la exposición tanto de las propiedades fagocíticas como hematopoyéticas. La neoplasia de estas células da como resultado la formación de ACL, que presenta características histológicas y moleculares consistentes con tipos de células epiteliales e histiocíticas.…”

Section: Discussionunclassified

Rotura Esplénica Espontánea Secundaria A Angioma de Células Litorales

Pérez-Alonso¹,

Olmo-Rivas²,

Machado-Romero³

et al. 2017

Panamerican Journal of Trauma, Critical Care &Amp; Emergency Surgery

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Introducción: Presentamos un angioma de células litorales (LCA, por sus siglas en inglés), una rara neoplasia vascular esplé-nica que surge de las células que recubren los senos de la pulpa roja. Se considera una lesión benigna y de hallazgo accidental.Presentación del caso: varón de 50 años acude con una rotura esplénica espontánea. Al principio del proceso, el paciente presentaba fatiga, debilidad y distensión abdominal. Se realizó una ecografía abdominal donde se observaron hemangiomas múltiples en el bazo. La tomografía computarizada reveló esplenomegalia con múltiples lesiones redondas e hiperdensas. El paciente fue sometido posteriormente a cirugía y se realizó una esplenectomía. Los estudios histológicos e immunohistoquímicos confirmaron el diagnóstico de LCA.Discusión: Un LCA es un tumor esplénico poco frecuente diagnosticado en pacientes que pueden o no presentar molestias abdominales. Suele presentarse con síntomas de hiperesplenismo, y debe realizarse el diagnóstico diferencial entre los tumores vasculares esplénicos divididos entre neoplasias benignas, indeterminadas, o neoplasias malignas.Conclusión: Debido a la asociación de LCA a neoplasias de colon, riñón, páncreas, pulmón, ovario, leiomiosarcoma, melanoma y linfoma, se debe descartar el neoplasma visceral en estos pacientes. Pocos informes sobre este tipo de tumor han sido publicados, y de manera inconsistente. Presentamos pues un nuevo caso y revisión de la literatura actual.Palabras Claves: Angioma de células litorales, Cirugía, Inmunohistoquímica e histología, Neoplasia vascular.How to cite this article: Pérez-Alonso AJ, Caballero-Marcos L, del Olmo-Rivas C, Machado-Romero I, Petrone P. Rotura Esplénica Espontánea Secundaria A Angioma de Células Litorales. Panam J Trauma Crit Care Emerg Surg 2017;6(2):131-133. Source of support: Nil Conflict of interest: None ABSTRACTIntroduction: We present a littoral cell angioma (LCA), a rare splenic vascular neoplasm that arises from the cells lining the red pulp sinuses. It is deemed to be a benign and incidental lesion. Case report:A 50-year-old male presented with a spontaneous splenic rupture. At the beginning of this process, the patient had abdominal distension, weakness and fatigue. An abdominal ultrasound was performed and multiple hemangiomas were observed in the spleen. Computed tomography scans revealed splenomegaly with multiple round and hyperdense lesions. The patient subsequently underwent surgery and a splenectomy was performed. Postoperative histological and immunohistochemical studies confirmed the diagnosis of LCA.Discussion: LCA is an uncommon splenic tumor diagnosed in patients presenting with or without abdominal discomfort. It can present with symptoms of hyperesplenism, and the differential diagnosis of splenic vascular tumors can be divided into benigns, indeterminate, or malignant neoplasms. Conclusion:Due to its association with neoplasms of the colon, kidney, pancreas, lung, ovary, leiomyosarcoma, melanoma and lymphoma, becomes mandatory to rule out a visceral neoplasm from the...

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“…Görg et al 16 reported 2 cases and reviewed 5 additional cases of littoral cell angioma in the literature; all cases were hyperechoic, and 6 (86%) were multiple lesions. However, in 20 cases of littoral cell angioma reported in the English literature, [3][4][5][6][7][8][9][10][11][12][17][18][19][20][21][22][23][24] 10 cases (50%) were hyperechoic, 10 (50%) were hypoechoic or isoechoic, and 12 (60%) were multiple lesions. In our study, 2 patients (29%) had multiple hyperechoic lesions, and 5 (71%) had solitary hypoechoic lesions.…”

Section: Discussionmentioning

confidence: 99%

“…[10][11][12]18,19 The lesions were avascular in 2 cases, hypovascular in 2 cases, and hypervascular in 1 case. In our study, the lesions were hypovascular in 4 cases and hypervascular in 3 cases.…”

Section: Discussionmentioning

confidence: 99%

“…This color flow pattern is similar to that of active Graves disease, which has been presented as marked color flow throughout the entire nodule 25 and has not been reported in littoral cell angioma so far. [10][11][12]18,19 Several studies have described the contrast-enhanced sonographic findings of various splenic lesions. 14,26,27 Benign vascular tumors in the spleen typically present as isoenhancement or a short period of slight hyperenhancement during the arterial phase and isoenhancement or hypoenhancement during the parenchymal phase.…”

Section: Discussionmentioning

confidence: 99%

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Littoral Cell Angioma of the Spleen

Yunhua

Liu

Wang

et al. 2013

Journal of Ultrasound in Medicine

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Objectives The purpose of this study was to evaluate the sonographic and pathologic features of littoral cell angioma of the spleen in 7 patients. Methods The sonographic appearance in 7 cases of littoral cell angioma confirmed by surgical pathologic examination was retrospectively reviewed. All underwent color Doppler imaging. Two underwent contrast‐enhanced sonography. The sonographic appearance was compared with pathologic findings. Results Splenic lesions were solitary in 5 cases and multiple in 2 cases. The masses ranged from 10 to 64 mm in maximum diameter. Five hypoechoic and 2 hyperechoic lesions on grayscale sonography corresponded to few and multiple blood‐filled spaces on pathologic examination, respectively. Four hypovascular lesions, 1 hypervascular lesion, and the other 2 hypervascular lesions full of color flow signals on color Doppler imaging corresponded to few, several, and multiple arteries on pathologic examination. On contrast‐enhanced sonography, 1 hypervascular lesion full of color flow signals showed homogeneous hyperenhancement for 8 minutes during the arterial and parenchymal phases. One hypovascular lesion showed inhomogeneous isoenhancement transiently during the arterial phase and became hypoechoic later. Conclusions Littoral cell angioma is a primary vascular splenic neoplasm with variable features on grayscale sonography and color Doppler imaging as well as contrast‐enhanced sonography. The sonographic appearance of littoral cell angioma mainly depends on the type and number of tumor vessels.

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Incidental littoral cell angioma of the spleen

Abstract: Background: Littoral cell angioma (LCA) is a recently described primary vascular neoplasm of the spleen that may be associated with other malignancies and may itself also have malignant potential.

Cited by 26 publications

References 33 publications

Is littoral cell angioma of the spleen as rare as previously believed in the pediatric population?

Is littoral cell angioma of the spleen as rare as previously believed in the pediatric population?

Rotura Esplénica Espontánea Secundaria A Angioma de Células Litorales

Littoral Cell Angioma of the Spleen

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