Incidental meningiomas in autopsy study

Nakasu, Satoshi; Hirano, Atsushi; Shimura, Toshiro; Llena, Josefina F.

doi:10.1016/0090-3019(87)90005-x

Cited by 201 publications

(99 citation statements)

References 7 publications

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“…Remarkably, in NF2 patients, the tumour burden (including meningiomas) is usually defined at a young age, with fewer tumours arising de novo later in adulthood (da Cruz et al, 2000). Moreover, the typical growth rate of benign meningiomas is slow (Olivero et al, 1995;Nakamura et al, 2003), and most meningiomas remain asymptomatic throughout life (Vernooij et al, 2007), such that nearly half of all meningiomas are incidentally discovered at autopsy (Nakasu et al, 1987). These observations suggest that meningioma initiation from a common PGDS ( þ ) progenitor cell may be an early event, whereas tumour development may take decades more to form by the addition of genetic and/or epigenetic events.…”

Section: Discussionmentioning

confidence: 99%

Identification of a progenitor cell of origin capable of generating diverse meningioma histological subtypes

et al. 2011

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Meningiomas are among the most common primary central nervous system tumours in adults. Studies focused on the molecular basis for meningioma development are hampered by a lack of information with regard to the cell of origin for these brain tumours. Herein, we identify a prostaglandin D synthase-positive meningeal precursor as the cell of origin for murine meningioma, and show that neurofibromatosis type 2 (Nf2) inactivation in prostaglandin D2 synthase (PGDS) ( þ ) primordial meningeal cells, before the formation of the three meningeal layers, accounts for the heterogeneity of meningioma histological subtypes. Using a unique PGDSCre strain, we define a critical embryonic and early postnatal developmental window in which biallelic Nf2 inactivation in PGDS ( þ ) progenitor cells results in meningioma formation. Moreover, we identify differentially expressed markers that characterize the two major histological meningioma subtypes both in human and mouse tumours. Collectively, these findings establish the cell of origin for these common brain tumours as well as a susceptible developmental period in which signature genetic mutations culminate in meningioma formation.

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Section: Discussionmentioning

confidence: 99%

Identification of a progenitor cell of origin capable of generating diverse meningioma histological subtypes

et al. 2011

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“…Intracranial meningiomas are more common in women than men and usually occur in patients aged 50-60 years. About 2-3% of the population has been reported to have an incidental meningioma (18). Even if the majority of meningiomas have benign histological features and complete removal is associated with good prognosis, atypical and malignant meningiomas constitute nearly 6% and 2% of cases, respectively, and have been linked with increased risk of recurrence (1,13,14).…”

Section: Introductionmentioning

confidence: 99%

Expression of stem cell marker nestin and microrna-21 in meningiomas

Galani

Alexiou²,

Miliaras³

et al. 2015

Turkish Neurosurgery

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AIm: Meningiomas are one of the most common benign intracranial tumors, making up nearly one third of all primary intracranial tumors. The majority of meningiomas have benign histological features and total resection is associated with favourable prognosis. Atypical and malignant meningiomas are associated with increased risk of recurrence. In the present study we set out to investigate the role of nestin mRNA levels and miR-21 in meningiomas. mATeRIAL and meTHods:We studied 17 patients with meningiomas that were treated surgically in our institute. Clinical variables that were analyzed were age, sex and histology. The expression of stem cell marker nestin mRNA levels and miR-21 was investigated in tissue samples by qRT-PCR.ResuLTs: Considerable levels of both miR-21 and nestin mRNA were found. Atypical and anaplastic meningiomas had higher expression of both miR-21 and nestin compared to benign tumors. Furthermore, a trend towards a positive correlation between miR-21 and nestin mRNA levels was also found.CoNCLusIoN: Increased miR-21 and nestin mRNA levels were found in anaplastic meningiomas, in which recurrence is common, and the role of miR-21 and Nestin in meningiomas therefore warrants further investigation.

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“…Na presente série, os meningiomas corresponderam a 22,4% das neoplasias primárias do SNC, sendo superior ao índice encontrado no Japão (12,3%) e Estados Unidos (13 a 19%) e assemelhandose à China (22,3%) 1018,19,30 . O aspecto heterogêneo das populações investigadas parece justificar esta discrepância.…”

Section: Discussionunclassified

“…Localizam-se preferencialmente na convexidade cerebral, foice, tenda cerebelar, sulcos olfatórios e asa menor do osso esfenóide 11,19,21,25 . Diversos fatores etiológicos têm sido implicados na gênese dos meningiomas, incluindo trauma, irritação meníngea crônica por hematoma subdural, infecções crônicas e efeitos tardios de tratamentos radioterápicos em baixas doses (até 1000 rads) para tinea capitis ou de altas doses para tratamento de gliomas e metastases 1418 - 21,29 .…”

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Meningiomas: estudo epidemiologic e anátomo-patológico de 304 casos

Torres¹,

Madalozzo

Werner³

et al. 1996

Arq. Neuro-Psiquiatr.

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RESUMO -No presente estudo, foram pesquisados os tumores do sistema nervoso central (SNC) diagnosticados na cidade de Curitiba entre 1990 e 1994. Realizaram-se 2371 biópsias de SNC das quais 1340 casos eram neoplasias primárias. Dentre as neoplasias primárias de SNC 304 (22,6%) eram meningiomas. Duzentos e nove meningiomas ocorreram em mulheres (68,7%) e 95 ocorreram em homens (31,3%). As idades variaram de 3 a 90 anos, com média de 45,8 anos. Duzentos e oitenta meningiomas localizavam-se no cérebro, 10 na medula espinhal, 9 no cerebelo e 5 na emergência de nervos cranianos. Na classificação histológica verificou-se que 294 (96,7%) eram do tipo clássico, 6 malignos (ou anaplásicos), 3 atípicos e 1 papilar. No grupo dos meningiomas clássicos 267 eram meningoteliais, 10 psamomatosos, 5 fibroblásticos, 5 microcísticos, 5 transicionais e 2 angiomatoses. Os autores concluem que as neoplasias meníngeas representaram o grupo mais frequente de tumores primários do SNC e apresentaram características epidemiológicas e anátomo-patológicas similares às da literatura mundial, na qual é dada ênfase à dificuldade de estabelecer critérios biológicos e histológicos de malignidade neste grupo de tumores. PALAVRAS-CHAVE: tumor cerebral, meningioma, epidemiologia, histopatologia. Meningiomas: epidemiological and pathological studies of 304 casesABSTRACT -The authors have retrospectively reviewed all tumors of central nervous system (CNS) operated at the most important neurosurgery hospitals of Curitiba in a 5-year period (1990)(1991)(1992)(1993)(1994) and found 304 (22.4%) cases of meningioma. Age mean of the patients was 48.5 years, with a range of 3 to 90 years. A marked female preponderance (68.7%) was noted. The most common tumor location was brain (n=280) and the remaining cases occurred in spinal cord (n=10), cerebellum (n=9) and cranial nerves (n=5). Histologically, there were 294 (96.7%) meningiomas of the classical type, six malignant or anaplastic, three atypical and one papillary. Two hundred and sixty seven classical meningiomas were from the meningotelial subtype, ten psamomatousos, five fibroblastic, five microcystic, five transicional and two angiomatous. The authors conclude that meningiomas are one of the most common group of primary neoplasias of CNS and the definition of malignancy in those tumors is beset by frequent discordance between histologic and biologic features.KEY WORDS: brain tumor, meningioma, epidemiology, histopathology.O conhecimento do comportamento biológico das neoplasias depende diretamente do correto diagnóstico anátomo-patológico e de elementos clínicos e epidemiológicos. Inúmeros estudos demonstram a relação entre o meio ambiente e o desenvolvimento de algumas neoplasias. Diante disto, em 1990, foi criado o

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Incidental meningiomas in autopsy study

Cited by 201 publications

References 7 publications

Identification of a progenitor cell of origin capable of generating diverse meningioma histological subtypes

Identification of a progenitor cell of origin capable of generating diverse meningioma histological subtypes

Expression of stem cell marker nestin and microrna-21 in meningiomas

Meningiomas: estudo epidemiologic e anátomo-patológico de 304 casos

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