Incidental Pituitary Macroadenoma: A Population-Based Study

Nammour, Gloria M.; Ybarra, Juan; Naheedy, Mohammad H.; Romeo, June Hart; Aron, David C.

doi:10.1016/s0002-9629(15)40224-1

Cited by 7 publications

(6 citation statements)

References 14 publications

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“…This difference is due to the lower spatial resolution and partial-volume effect of PET, which is limited in the detection of pituitary microadenomas smaller than 10 mm. Two previous studies found the prevalence of macroadenoma to be 0.16%-0.20% (13,14). In the present study population, the estimated prevalence of macroadenoma was 0.24%, which is comparable to previous reports.…”

Section: Discussionsupporting

confidence: 85%

Incidental Focal ¹⁸F-FDG Uptake in the Pituitary Gland: Clinical Significance and Differential Diagnostic Criteria

Hyun¹,

Choi²,

Lee³

et al. 2011

J Nucl Med

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Section: Discussionsupporting

confidence: 85%

Incidental Focal ¹⁸F-FDG Uptake in the Pituitary Gland: Clinical Significance and Differential Diagnostic Criteria

Hyun¹,

Choi²,

Lee³

et al. 2011

J Nucl Med

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“…In previously published studies, subclinically or incidentally detected macroadenomas were also very rare (3,7,26). Our statistical analysis did not reveal a clear significant correlation between clinical data and adenoma type.…”

Section: Discussioncontrasting

confidence: 67%

Subclinical adenomas in postmortem pituitaries: classification and correlations to clinical data

2006

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Objective: The aim of this study was to examine pituitary adenomas in a series of postmortem pituitaries by use of modern technologies of immunostaining, to classify the adenomas according to the current WHO classification and to analyse the possible associations to the available clinical data. Methods: In this study, pituitaries of 3048 autopsy cases obtained from autopsy series of the years 1991-2004 were examined. Results: A total of 334 pituitary adenomas were found in 316 pituitaries. One hundred and thirty-two sparsely granulated prolactin cell adenomas (39.5%), 75 null cell adenomas (22.5%) and 31 oncocytomas were diagnosed. Forty-six ACTH cell adenomas (13.8%, 27 densely granulated, 19 sparsely granulated) and one adenoma composed of Crooke's cells were detected. Twenty-two gonadotroph cell adenomas (6.6%), seven GH cell adenomas (four sparsely granulated, three densely granulated), one mixed GH cell-PRL cell adenoma, two TSH cell adenomas, five plurihormonal adenoma type I, four plurihormonal adenoma type II and two a-subunit-only adenomas were seen. Six adenomas remained unclassified because the tissue was not contained in all sections for immunohistochemistry. Seventeen pituitaries included multiple tumours. The overall tumour size ranged from 0.1 to 20 mm in diameter. Among 76 adenomas (22.7%), which had a tumour size of R3 mm, only three tumours were macroadenomas corresponding to a tumour size of more than 10 mm. The evaluation of the available clinical data showed 99 cases of hypertension, 65 cases of diabetes mellitus, six patients with hyper-thyroidism and four with hypothyroidism. No symptoms of adenohypophyseal hormone hypersecretion were reported. The statistical correlations to clinical data were discussed. Conclusions: Adenomas in postmortem pituitaries differ from those in surgical series in proportion of adenoma types and biological behaviour. European Journal of Endocrinology 154 753-758

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“…MRI studies in unselected populations report micro-incidentaloma rates of 10-38% (16,17). Similar to autopsy series the percentage of macroadenomas is quite low: 0.2% in CT series (18) and 0.16-0.3% in MRI studies (19,20). These data derived from normal populations or apparently asymptomatic patients are in contrast with the prevalence of clinically relevant pituitary adenomas, which is closer to 1 case per 1064-1200 (21,22).…”

Section: How Frequent Are Pituitary Incidentalomas?supporting

confidence: 60%

MANAGEMENT OF ENDOCRINE DISEASE: Pituitary ‘incidentaloma’: neuroradiological assessment and differential diagnosis

Васильев

Rostomyan

Daly

et al. 2016

European Journal of Endocrinology

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Pituitary incidentalomas are a by-product of modern imaging technology. the term 'incidentaloma' is neither a distinct diagnosis nor a pathological entity. Rather, it is a collective designation for different entities that are discovered fortuitously, requiring a working diagnosis based on the input of the radiologist, endocrinologist and often a neurosurgeon. In addition to pathological conditions affecting the pituitary gland, a thorough knowledge of the radiological characteristics of normal variants and technical artifacts is required to arrive at an accurate differential diagnosis. after careful radiological and hormonal evaluation, the vast majority of pituitary incidentalomas turn out to be non-functioning pituitary microadenomas and Rathke's cleft cysts (Rccs). Based on the low growth potential of non-functioning pituitary microadenomas and Rccs, periodic MRI surveillance is currently considered the optimal management strategy. stricter follow-up is required for macroadenomas, as increases in size occur more frequently.

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Incidental Pituitary Macroadenoma: A Population-Based Study

Cited by 7 publications

References 14 publications

Incidental Focal ¹⁸F-FDG Uptake in the Pituitary Gland: Clinical Significance and Differential Diagnostic Criteria

Incidental Focal ¹⁸F-FDG Uptake in the Pituitary Gland: Clinical Significance and Differential Diagnostic Criteria

Subclinical adenomas in postmortem pituitaries: classification and correlations to clinical data

MANAGEMENT OF ENDOCRINE DISEASE: Pituitary ‘incidentaloma’: neuroradiological assessment and differential diagnosis

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Incidental Pituitary Macroadenoma: A Population-Based Study

Cited by 7 publications

References 14 publications

Incidental Focal 18F-FDG Uptake in the Pituitary Gland: Clinical Significance and Differential Diagnostic Criteria

Incidental Focal 18F-FDG Uptake in the Pituitary Gland: Clinical Significance and Differential Diagnostic Criteria

Subclinical adenomas in postmortem pituitaries: classification and correlations to clinical data

MANAGEMENT OF ENDOCRINE DISEASE: Pituitary ‘incidentaloma’: neuroradiological assessment and differential diagnosis

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Product

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Incidental Focal ¹⁸F-FDG Uptake in the Pituitary Gland: Clinical Significance and Differential Diagnostic Criteria

Incidental Focal ¹⁸F-FDG Uptake in the Pituitary Gland: Clinical Significance and Differential Diagnostic Criteria