Incidental Thyroid Carcinoma in a Large Series of Consecutive Patients Operated on for Benign Thyroid Disease

Miccoli, Paolo; Minuto, Michele; Galleri, David; D’Agostino, Jacopo; Basolo, Fulvio; Antonangeli, L; Aghini-Lombardi, F.; Berti, Piero

doi:10.1111/j.1445-2197.2006.03667.x

Cited by 119 publications

(117 citation statements)

References 23 publications

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“…The time of diagnosis of hyperthyroidism to thyroidectomy was not diff erent. However, Miccoli et al reported that, the diagnosis of incidental thyroid carcinoma in patients who were operated on for a benign disease was more frequent in euthyroid patients than in patients with hyperthyroidism [ 23 ] .…”

Section: ▼ Thyroid Cancer In Patients With Hyperthyroidismmentioning

confidence: 99%

Thyroid Cancer in Patients with Hyperthyroidism

2012

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Section: ▼ Thyroid Cancer In Patients With Hyperthyroidismmentioning

confidence: 99%

Thyroid Cancer in Patients with Hyperthyroidism

2012

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“…However, it seems that, despite all efforts, small tumoral lesions might be left undiagnosed preoperatively in patients with multiple nodules. It is known that the majority of incidental thyroid carcinomas are PTC (21). Higher rate of PTC in EMNG might be attributed to the incidentality of nearly half the malignant lesions in this group of patients.…”

Section: Discussionmentioning

confidence: 99%

Thyroid malignancy risk in different clinical thyroid diseases

Dirikoç¹,

Fakı²,

Başer³

et al. 2017

Turk J Med Sci

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Background/aim: To evaluate the malignancy risk of thyroid nodules in different clinical thyroid diseases. Materials and methods:Patients who underwent thyroidectomy between 2007 and 2014 were grouped as euthyroid, hypothyroid, and hyperthyroid. Further classification was made depending on the presence of solitary/multiple thyroid nodules.Results: Among 2870 patients, 1719 (59.9%) were euthyroid, 962 (33.5%) were hyperthyroid, and 189 (6.6%) were hypothyroid. Overall malignancy was detected in 980 (34.1%) patients. Malignancy rates were 42.1%, 42.9%, and 18.3% in the euthyroid, hypothyroid, and hyperthyroid groups, respectively (P < 0.001). A total 41.4% of patients with euthyroid nodular goiter (ENG) and 46.3% of patients with euthyroid multinodular goiter (EMNG) had thyroid malignancy (P = 0.169). Mean tumor size and capsular and vascular invasion were significantly lower in EMNG than in ENG. Among hypothyroid patients, 45.7% with solitary and 42.2% with multiple nodules were malignant (P = 0.705). When toxic nodular goiter and toxic multinodular goiter were analyzed together, malignancy rate was 24.7% (104/421), and when Graves with nodule/nodules was considered, it was 19.7% (59/299). Conclusion:In hypothyroid or euthyroid patients who underwent thyroidectomy, malignancy rate was higher than 40%, and was lower in hyperthyroid patients. Patients with multiple nodules carry a similar risk of malignancy as patients with solitary nodules, independent of the functional status.

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“…In recent years, it is well known that frequency of thyroid procedures and incidental findings of thyroid cancer has been arising with an average rate of 10% [13,14]. Particularly, incidental finding of papillary microcarcinoma has been reported in a large number of patients undergoing thyroidectomy for benign thyroid disease, reaching up to 24% [15].…”

Section: Discussionmentioning

confidence: 99%

“…However, an increased risk of non-parathyroid cancers in patients with pHPT has been reported in several studies [18]. Miccoli et al [13] reported thyroid malignancy as the most prevalent cancer among those patients in whom pHPT was [4,5,17,[19][20][21], others investigated several predisposing factors such as exposure to neck radiation, goitregenic effect and increased mitotic activity induced by hypercalcemia [22,23]. In addition, tumour-promoting effect of parathyroid hormone and subsequent genetic predisposition to new malignancies were also noted [16,24].…”

Section: Discussionmentioning

confidence: 99%

Incidental Finding of Papillary Thyroid Carcinoma in the Patients with Primary Hyperparathyroidism

Yazici¹,

Mihmanlı²,

Bozdağ³

et al. 2015

Eurasian J Med

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Objective: The relationship between primary hyperparathyroidism (pHPT) and papillary thyroid cancer (PTC) still remains unclear. We aimed to investigate the incidence of the co-existence of pHPT and PTC. Materials and Methods:Between 2010 and 2013, all patients with pHPT were retrospectively reviewed and those undergoing concomitant thyroid surgery were recorded. Of these, patients with a pathological result showing papillary or micro-papillary thyroid cancer were included into the study. A chart review of 228 patients who underwent surgery for pHPT revealed 86 (37.7%) patients with concurrent thyroid disease requiring surgical treatment. Results:Thyroid cancer was noted in six female patients (6.9%) undergoing thyroid resection, and 2.6% of all patients with pHPT. Four patients underwent total thyroidectomy while lobectomy was applied in the remaining two. None of the cases with lobectomy required a completion thyroidectomy. Conclusion:We demonstrated the concurrence of PTC and pHPT at a rate of 2.6% which appeared as a coincidental pathology; however, thyroid disorders, seen in one of three patients with pHPT, were not uncommon. Further research is still needed to develop a reliable explanation for relationship between pHPT and non-medullary thyroid cancer.Keywords: Primary hyperparathyroidism, thyroid disorders, surgical treatment, papillary thyroid cancer Özet Amaç: Her ne kadar primer hiperparatiroidi (pHPT) ile medüller tiroid kanser ilişkisi bilinse de papiller tiroid kanseri ile ilişkisi halen net değildir. Biz bu çalışmada pHPT tanısı nedeniyle opere ettiğimiz hastalardaki papiller tiroid kanser sıklığını incelemeyi amaçladik. Gereç ve Yöntem:Primer HPT tanısı ile 2010 ve 2013 yılları arasın-da eş zamanlı tiroid cerrahisi uygulanan hastalar retrospektif olarak incelendi. Bu hastalardan patoloji sonucunda papiller veya mikropapiller trioid kanseri tanısı alan hastalar çalışmaya dahil edildi. Çalış-ma sürecinde pHPT tanısı ile cerrahi tedavi uygulanan 228 hastadan 86'sında (%37,7) ek tiroid cerrahisi uygulandığı saptandı. Bulgular:Ek tiroid cerrahisi uygulanan 6 kadın hastada (%6,9)-pHPT hastalarının %2,6'sı tiroid kanseri saptandı. Dört hastada total tiroidektomi papiller diğer 2 hastada lobektomi yapıldı. Hastaların hiçbi-rinde tamamlayıcı tiroidektomiye ihtiyaç duyulmadı. Sonuç:Primer HPT hastalarında %30 oranında tiroid patolojisi izlenmesine rağmen %2,6 gibi düşük bir orandaki tiroid kanser birlikteliği tesadüfi olarak ilişkilendirilebilir. Fakat medüller olmayan tiroid kanseri ile pHPT arasındaki bağa daha güvenilir bir açıklama getirebilmek için ileri çalışmalar gerekmektedir.

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Incidental Thyroid Carcinoma in a Large Series of Consecutive Patients Operated on for Benign Thyroid Disease

Cited by 119 publications

References 23 publications

Thyroid Cancer in Patients with Hyperthyroidism

Thyroid Cancer in Patients with Hyperthyroidism

Thyroid malignancy risk in different clinical thyroid diseases

Incidental Finding of Papillary Thyroid Carcinoma in the Patients with Primary Hyperparathyroidism

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