Incidental uptake of 123I MIBG in brown fat

Ochoa-Figueroa, M.A.; Muñoz-Iglesias, J.; Allende-Riera, A.; Cabello-García, D.; Martínez-Gimeno, E.; DeSequera-Rahola, M.

doi:10.1016/j.remnie.2011.10.002

Cited by 2 publications

(3 citation statements)

References 2 publications

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“…Researchers found that the metabolic disorders of adipose and the occurrence of obesity are associated with calcium signaling pathways by performing the global transcriptome analysis of brown adipose tissue in obese mice [76]. By using I-mIBG imaging, some researchers indicated that the sympathetic nerve might regulate the metabolism of brown adipose through calcium signaling pathways [77,78].…”

Section: The Nervous System Regulates the Occurrence Of Obesity Thmentioning

confidence: 99%

Calcium Signaling Pathways: Key Pathways in the Regulation of Obesity

Song

Wang

Zhang

et al. 2019

IJMS

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Nowadays, high epidemic obesity-triggered hypertension and diabetes seriously damage social public health. There is now a general consensus that the body’s fat content exceeding a certain threshold can lead to obesity. Calcium ion is one of the most abundant ions in the human body. A large number of studies have shown that calcium signaling could play a major role in increasing energy consumption by enhancing the metabolism and the differentiation of adipocytes and reducing food intake through regulating neuronal excitability, thereby effectively decreasing the occurrence of obesity. In this paper, we review multiple calcium signaling pathways, including the IP3 (inositol 1,4,5-trisphosphate)-Ca2+ (calcium ion) pathway, the p38-MAPK (mitogen-activated protein kinase) pathway, and the calmodulin binding pathway, which are involved in biological clock, intestinal microbial activity, and nerve excitability to regulate food intake, metabolism, and differentiation of adipocytes in mammals, resulting in the improvement of obesity.

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Section: The Nervous System Regulates the Occurrence Of Obesity Thmentioning

confidence: 99%

Calcium Signaling Pathways: Key Pathways in the Regulation of Obesity

Song

Wang

Zhang

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…The involvement of the SNS in BAT activation through excess levels of catecholamines is clearly seen in several studies describing increased uptakes of both 18 F-FDA and 123 I-mIBG in BAT in patients with phaeochromocytoma [25][26][27]. Strikingly, the presence of phaeochromocytoma appears to induce metabolic BAT activity at the usual sites (for example, the shoulder-neck region, along the greater vasculature), as well as at less typical places (such as perinephric adipose tissue) and even at atypical places (omental fat) [28,29,53-61].…”

Section: Bat Activation Through High Catecholamine Levelsmentioning

confidence: 98%

“…Since then, several imaging studies using 123 I-mIBG have suggested the importance of sympathetic innervation for BAT [24][25][26]31]. In a retrospective study of paediatric patients with neuroendocrine tumors, the accumulation of 123 I-mIBG at BATspecific sites was observed with 123 I-mIBG SPECT [31].…”

Section: Imaging Studies Highlighting the Importance Of The Sns In Bamentioning

confidence: 99%