Incidentally detected renal adenomatosis in a patient with urolithiasis

Abstract

A renal epithelial tumor with a papillary or tubulopapillary pattern and a low nuclear grade is defined as a renal adenoma if its diameter is 5 mm or less. Two important issues related to the renal adenoma are the lack of exact criteria for the histopathological differentiation from a papillary renal cell carcinoma and the lack of consensus as to whether it is a precancerous lesion. Renal adenomatosis is very rarely seen entity entity characterized by multiple and usually bilateral adenomas. Innumerable adenomas, adenomatous transformations within a single tubule and adenomas measuring 7 mm or less, were detected in a 47-year-old man who underwent simple nephrectomy due to nonfunctional hydronephrosis secondary to urolithiasis. In this paper, our diagnostic approach to this fairly rare entity is discussed along with a brief literature review.

Renal adenomatosis

“…Herein, some neoplastic foci revealed various overlapping features between carcinoma and adenoma. Adenomatosis can arise on the grounds of a hydronephrosis secondary to urolithiasis [7] as in our case, or in the setting of acquired renal cystic disease. Interestingly, in patients with acquired polycystic kidney disease, papillary adenomas do not show the expression of AMACR, suggesting the involvement of a different biological mechanism [8].…”