Incidentally discovered adrenal myelolipoma associated with hyperthyroidism

Ide, Hisamitsu; Terado, Yuichi; Nakagawa, Takashi; Saito, Keisuke; Kamiyama, Yutaka; Muto, Satoru; Okada, Hiroshi; Imamura, Tetsuo; Horie, Shigeo

doi:10.1007/s10147-007-0662-1

Cited by 13 publications

(8 citation statements)

References 9 publications

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“…The cause of the hypersecretion is largely unknown but may be due to mechanical irritation of the adrenal myelolipoma. Also, hyperthyroidism was noted in 51-year-old woman with adrenal myelolipoma (Ide et al 2007). In this case, the cells in the myelolipoma expressed thyroid hormone receptor.…”

Section: Myelolipomamentioning

confidence: 54%

Lipomatous tumours in adrenal gland: WHO updates and clinical implications

Lam¹

2017

Endocrine-Related Cancer

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Adrenal lipomatous tumour is a group of adrenal tumours with a significant component of adipose tissue. According to the current World Health Organization (WHO) classification of tumours of endocrine organs, adrenal myelolipoma is the only entity amongst the group of tumours being described. In the literature, other more recently documented adrenal lipomatous tumours included 24 lipomas, 32 teratomas and 16 angiomyolipomas. Rare fatty tumours of the adrenal gland comprised liposarcoma, hibernoma, adrenocortical tumours with fat component and rare adrenal tumours with fat component. Myelolipoma comprises approximately 3% of primary adrenal tumour. It is noted more commonly in females and in the right adrenal gland. Approximately 40 bilateral myelolipomas were reported. The tumour is most frequently recorded in patients between fifth and seventh decades of life. Adrenal lipomas are often seen in males and in the right adrenal gland. They were commonly noted in patients in the sixth decade of life. The diagnosis could only be possible on examination of the surgically removed specimen. Adrenal teratomas were more common in females and with a bimodal age distribution. Slightly over 60% of the patients with adrenal teratoma are symptomatic. Adrenal angiomyolipomas were often symptomatic, more common in females and in the fifth decades of life. To conclude, adrenal lipomatous tumour is uncommon. They are often benign and non-functional. It is important to recognize the features of this group of lipomatous tumours in the adrenal gland as they are being detected on increasing incidence as a result of the wide-spread use of modern imaging modalities.

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Section: Myelolipomamentioning

confidence: 54%

Lipomatous tumours in adrenal gland: WHO updates and clinical implications

Lam¹

2017

Endocrine-Related Cancer

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“…Adrenal myelolipomas associated with endocrine disorders have been reported , and various theories about the etiology of this disease have been presented. 3 Some studies referred to the possibility that stimulation by hypercortisolism, hyperthyroidism and increased ACTH mediated transformation of adrenal cortical cells to myeloid cells and fatty replacement, 3,4 whereas others proposed that necrosis of the adrenal tissue caused by peripheral circulatory disturbance resulted in tumorigenesis of myelolipoma. 5 However, the patient in the current case had normal levels of ACTH, serum cortisol and thyroid hormone, as well as no complications known to be associated with necrosis.…”

Section: Discussionmentioning

confidence: 99%

Adrenal myelolipoma associated with hyperandrogenemia

Huang

Dai

et al. 2012

Int J of Urology

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Adrenal myelolipoma associated with hyperandrogenemia is extremely rare. We present such a case here. The patient was a 34-year-old Chinese woman with a history of growth retardation, virilization and lumbago. Adrenal imaging showed a circular soft tissue mass in the right adrenal gland. Endocrine examinations showed increased levels of plasma testosterone and dehydroepiandrosterone sulfate, significantly lower levels of follicle-stimulating hormone and luteinizing hormone, with other biochemical parameters being basically normal. After a histopathological study confirming the mass to be an adrenal myelolipoma, the patient was managed with a right adrenalectomy and then recovered. A search of the English and Japanese language literature suggests this is the first detailed and documented case of adrenal myelolipoma associated with hyperandrogenemia.

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“…The persistent excessive stimulation by hormones secreted by abnormal adrenal cortex might also play a role as a mediator in transforming adrenal tissue into myeloid cells and fatty replacement in hormonally active cases. 6,7 Therefore, on the basis of aforementioned experts' views and our discovery, adrenal myelolipoma and atypical hyperplasia of adrenal cortex may be anatomically and functionally related in hormonally active cases. The imaging characteristics of hormonally inactive and hormonally active adrenal myelolipomas are similar -dense fatty tissue is the diagnostic key.…”

Section: Discussionmentioning

confidence: 84%

Pathologic analysis, diagnosis and treatment of adrenal myelolipoma

Zhou

Huang

et al. 2014

CUAJ

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With the widespread use of non-invasive imaging modalities, the incidental detection of myelolipoma has become more common. We analyze the clinical data of 4 typical cases of unilateral adrenal myelolipomas, including 1 hormonally inactive patient and 3 hormonally active cases with hyperaldosteronemia, hypercortisolism and hyperandrogenemia. Obvious differences were found in the pathological sections. To our knowledge, this is the first article discussing the etiology of adrenal myelolipoma from pathologic analyses.

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Incidentally discovered adrenal myelolipoma associated with hyperthyroidism

Cited by 13 publications

References 9 publications

Lipomatous tumours in adrenal gland: WHO updates and clinical implications

Lipomatous tumours in adrenal gland: WHO updates and clinical implications

Adrenal myelolipoma associated with hyperandrogenemia

Pathologic analysis, diagnosis and treatment of adrenal myelolipoma

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