Incidentally Found Prostate Cancer and Influence on Overall Survival after Radical Cystoprostatectomy

Abstract

Objectives. To determine incidentally found prostate cancer frequency and impact on overall survival after RCP. Patients and Methods. The records of 81 men who underwent cystoprostatectomy from January 2000 to December 2009 were reviewed. The vital status of the study group was assessed as on September 1, 2009, by passive followup, using data from the population registry. Results. The 81 men underwent RCP. The incidental prostate cancer was found in the specimens of 27 (33.3%) patients. 13 (48.1%) of 27 prostate cancer cases were clinically significant. For 3 patients (11.1%) an extraprostatic extension was found. For 2 patients (7.4%)—positive margins, for 1 patient (3.7%)—Gleason sum 8, and for the rest 7 patients bigger than 0.5 cm3 volume tumor, and Gleason sum 7 was found. The mean follow-up time was 39.2 ± 33.8 months (varies from 0.8 to 131.2 months). The patients with bladder cancer and incidentally found prostate cancer lived shorter (28.1 ± 27.5 and 45.5 ± 35.40 months). Higher overall survival (P = 0.03) was found in the patient group with bladder cancer without incidentally diagnosed prostate cancer. Conclusion. There are indications that in this small study prostate cancer has influenced on patients' survival with bladder cancer after radical cystoprostatectomy.

Incidental prostate cancer in Asian men: High prevalence of incidental prostatic adenocarcinoma in Chinese patients undergoing radical cystoprostatectomy for treatment of bladder cancer and selection of candidates for prostate‐sparing cystectomy

“…The incidence of prostate cancer varies considerably between populations of the world. Most Asian countries, except Korea, present lower rates of incidental prostate cancer when compared with American, European, and Australian countries (Table ) . The present study shows a higher rate (28%) of incidental prostate cancer in China than in the majority of studies from other Asian countries .…”

The distribution of BCG prostatitis: A clue for pathogenetic processes?

“…Fifteen of 27 prostates (55.6%) contained incidental prostatic adenocarcinoma (Table ), an observation in keeping with published data . Three others (11.1%) showed high‐grade prostatic intraepithelial neoplasia (HGPIN) without invasion.…”

Incidental prostate cancer prevalence at radical cystoprostatectomy—importance of the histopathological work-up

“…The clinical relevance of incidental prostate cancers detected at radical CP remains questionable. Two studies demonstrated significantly worse survival after radical CP for patients with concurrent tumors [8,27], while Pritchett found no difference in the mortality rates [11]. In a recent series of 1476 patients, 22 % of the detected prostate cancers were classified as significant.…”