Incision of AP sites in lung cancer patients: a pilot study

Rossi, Ottavio; Filiberti, Rosangela; Neri, Monica; Biggi, Stefano; Satragno, L.; Puntoni, Riccardo; Fròsina, Guido

doi:10.1002/tcm.10018

Cited by 5 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The endpoints measured in these studies included levels of circulating proteins (HER-2/neu, mesothelin, osteopontin, mutated K-ras), growth factors (PDGF-AB, HGF, EGF, SCF) or antibodies (anti-p53), erythrocyte glycophorin-A variants, DNA adducts, micronuclei, DNA repair activities, SV40, and singlenucleotide polymorphisms in metabolic, DNA repair or other genes. A list of the published articles is reported in the references (17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34).…”

Section: The Crest Biorepository On Respiratory Tract Cancermentioning

confidence: 99%

The CREST Biorepository: A Tool for Molecular Epidemiology and Translational Studies on Malignant Mesothelioma, Lung Cancer, and Other Respiratory Tract Diseases

Ugolini

Neri²,

Aldo

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

Objectives: The Cancer of RESpiratory Tract (CREST) biorepository was established to investigate biological mechanisms and to develop tools and strategies for primary and secondary prevention of respiratory tract cancer. The CREST biorepository is focused on pleural malignant mesothelioma, a rare and severe cancer linked to asbestos exposure whose incidence is particularly high in the Ligurian region. Methods: The CREST biorepository includes biological specimens from (a) patients with pleural malignant mesothelioma and lung cancer, (b) patients with nonneoplastic respiratory conditions, and (c) control subjects. Whole blood, plasma, serum, lymphocytes, pleural fluid, saliva, and biopsies are collected, and a questionnaire is administered. Collection, transportation, and storage are done according to international standards. Results: As of January 31, 2008, the overall number of subjects recruited was 1,590 (446 lung cancer, 209 pleural malignant mesothelioma, and 935 controls). The biorepository includes a total of 10,055 aliquots (4,741 serum; 3,082 plasma; 1,599 whole blood; 633 pleural fluid; and 561 lymphocytes) and 107 biopsies. Demographic, clinical, and epidemiologic information is collected for each subject and processed in a dedicated database. Conclusions: The CREST biorepository is a valuable tool for molecular epidemiology and translational studies. This structure relies on a network of contacts with local health districts that allows for an active search for patients. This is a particularly efficient approach, especially when the object of the study is a rare cancer type. The CREST experience suggests that the presence of limited resources can be overcome by the biorepository specialization, the high quality of the epidemiologic information, and the variety of samples. (Cancer Epidemiol Biomarkers Prev 2008;17(11):3013 -9)

show abstract

Section: The Crest Biorepository On Respiratory Tract Cancermentioning

confidence: 99%

The CREST Biorepository: A Tool for Molecular Epidemiology and Translational Studies on Malignant Mesothelioma, Lung Cancer, and Other Respiratory Tract Diseases

Ugolini

Neri²,

Aldo

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

View full text Add to dashboard Cite

show abstract

“…No associations have been found for Flap endonuclease (DNAase IV/FEN-1 [135]), Ape/Ref-1 [136][137][138] and hMYH [139]. Gene-environment interactions with smoking have been found for the Ape/Ref-1 Asp148Glu polymorphism [131].…”

Section: Lung Cancermentioning

confidence: 99%