Incisional skin metastasis of a squamous cell cervical carcinoma 3.5 years after radical treatment-a case report

Srivastava, Kirti; Singh, Shalini; Srivastava, Meenu; Srivastava, Anand

doi:10.1111/j.1525-1438.2005.00173.x

Cited by 23 publications

(22 citation statements)

References 18 publications

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“…Rarely (0.1–1.3%), metastatic recurrence of squamous cervical carcinoma could be identified in the abdominal wall especially in sites of incision [1]. Metastatic skin incisional cancers are usually presenting in cases of adenocarcinomas of the ovaries, colon, pancreas, kidneys, or bladder [2]. Based on the common metastasis of such adenocarcinomas, one could understand the possible mechanism of cervical adenocarcinomas; however, it is difficult to clarify the mechanism in squamous cell carcinomas.…”

Section: Introductionmentioning

confidence: 99%

Incisional Site Metastasis in a Patient with Cervical Carcinoma: A Case Report and Review of the Literature

Iavazzo

Madhuri

Tailor

et al. 2012

Case Reports in Obstetrics and Gynecology

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Abdominal wall metastasis either incisional, drain, or port is rather rare in patients treated for cervical carcinoma. We present a case of a patient who underwent an abdominal radical hysterectomy for a moderately differentiated cervical adenocarcinoma stage Ib1 and presented an incisional site metastasis 36 months after her operation. Moreover, we performed a literature search for abdominal wall metastases after radical hysterectomy for cervical cancer, and we present a table of the relative case reports. After our literature search, we clarified that the median time of recurrence was 14 months (range 1.5 month to 45 months). Thirty-three out of 42, 8/42, and 1/42 were squamous, adeno-, and adenosquamous carcinomas, respectively. Wide excision was performed in 30/37 cases of which we have information regarding the treatment option, while 11/37 and 13/37 underwent radiotherapy and chemotherapy, respectively. The possible mechanism of such a metastasis as well as the treatment options is discussed.

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Section: Introductionmentioning

confidence: 99%

Incisional Site Metastasis in a Patient with Cervical Carcinoma: A Case Report and Review of the Literature

Iavazzo

Madhuri

Tailor

et al. 2012

Case Reports in Obstetrics and Gynecology

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“…Skin metastases from cervical carcinoma occur predominantly in cases of tumor recurrences [3]. A review of literature shows that most of skin metastases occurred after an interval less than 21 months except three cases reported by Behtash et al [3], Selo-Ojema et al [9], Srivastava et al [10] although the second case was adenocarcinoma of the cervix. In the present case, the patient developed umbilical metastasis without prior laparascopy or laparotomy.…”

Section: Discussionmentioning

confidence: 99%

“…Skin involvement was observed directly, so that deduction concerning its mechanism ought to be reliable and have applicability to the general question of the mode of spread of cervical cancer. The mechanism of involvement was thought to be retrograde lymphatic spread from the corresponding regional lymph nodes [10]. This Wnding seemed important because it emphasized the predominant role of lymphatics in the spread of cervical carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Umblical metastasis in cervical cancer

Behtash¹,

Mehrdad²,

Shamshirsaz³

et al. 2008

Arch Gynecol Obstet

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Introduction Objective cutaneous metastasis from carcinoma of the uterine cervix is an uncommon occurrence. The outcome of patients with skin metastasis is usually poor as they are often associated with locoregional recurrence. This metastasis impairs the quality of life and shortens survival. Consequently, physicians should be aware of the possible existence of skin metastasis in cervical cancer. Clinical suspicion should lead to a careful additional evaluation whenever a cutaneous nodule presents in the course of the disease. Case report We report a rare case of metastasis from squamous cell carcinoma of cervix to the umbilicus. The patient was diagnosed with stage IIB FIGO. Four months after chemoradiation patient presented with a nodule in the umbilical region. Biopsy performed and metastatic squamous cell carcinoma was diagnosed. Patient underwent salvage therapy with paclitaxel and carboplatin. Conclusion To the best of our knowledge, this is a rare reported occurrence of umbilical metastasis in cervical cancer without prior laparotomy or laparoscopy. This metastatic lesion has a grave prognosis and the mean survival is about 3 months like our case.

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“…This case, however, is distinctive for several reasons. First, in prior reports of cutaneous metastases from cervical squamous cell carcinoma, the grossly visible nodules are usually single or a small cluster of multiple papules [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] . In our patient's case, the cutaneous metastases were innumerable and located diffusely over the anterior abdominal wall, vulva, perineum, and bilateral proximal lower extremities (see Figure 1).…”

Section: Discussionmentioning

confidence: 99%

“…This clinical scenario is even less common in literature originating from the United States, due to the lower overall incidence of cervical cancer [3][4][5] . Case reports have documented various sites of cutaneous metastases, including the face and neck [6] , scalp [7][8][9] , vulva [5,[10][11] , upper and lower extremities [12][13] , umbilicus (Sister Mary Joseph nodule) [14] , trunk/abdominal wall [3][4][5]15] , and surgical incision/drain sites [16][17] . Prior authors have found that the occurrence of metastases to the skin generally implies terminal disease, with the average survival following diagnosis ranging from 3-6 months, even in cases where palliative chemo-and radiotherapy are administered [15] .…”

Section: Introductionmentioning

confidence: 99%

Cutaneous metastases from cervical squamous cell carcinoma in a 55 year-old woman: a rarely reported manifestation

McCarthy

Laucirica

2014

CRCP

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Squamous cell carcinoma of the cervix was once the most common gynecologic cancer in the world, accounting for significant morbidity and mortality. With the advent of routine Papanicolaou screening in the United States during the latter half of the twentieth century, cervical cancer now accounts for a much smaller proportion of cancer deaths. Despite the advances that have been made in screening and early detection, women of low socio-economic status and immigrants from other countries who may not have access to health care continue to present with high-stage disease. Manifestations of advanced disease include direct invasion of structures adjacent to the cervix and distant metastases to the lung, bone, and liver. In approximately 0.5-1 percent of cases, metastases to the skin and soft tissue occur, most commonly to the abdominal wall and vulva, followed less frequently by the perineum and extremities. This particular manifestation has come to be regarded as a sign of terminal disease, with most patients surviving 3-6 months despite chemotherapy. Clinically, this may not be a diagnosis that is anticipated by the pathologist examining the biopsy. We present the case of a 55 year-old woman with a history of untreated squamous cell carcinoma of the cervix who presented with rapidly spreading, painful erythematous papules of the vulva, lower anterior abdominal wall, and proximal lower extremities. This case highlights a rare presentation of metastatic squamous cell carcinoma of the cervix, and underscores the importance of obtaining adequate clinical history, investigating a wide range of diagnoses as part of the differential diagnosis, and distinguishing primary cutaneous squamous cell carcinoma from a metastasis.

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Incisional skin metastasis of a squamous cell cervical carcinoma 3.5 years after radical treatment-a case report

Cited by 23 publications

References 18 publications

Incisional Site Metastasis in a Patient with Cervical Carcinoma: A Case Report and Review of the Literature

Incisional Site Metastasis in a Patient with Cervical Carcinoma: A Case Report and Review of the Literature

Umblical metastasis in cervical cancer

Cutaneous metastases from cervical squamous cell carcinoma in a 55 year-old woman: a rarely reported manifestation

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