1983
DOI: 10.1212/wnl.33.9.1109
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Inclusion body myositis (IBM)

Abstract: Inclusion body myositis (IBM) is described in six elderly patients (three women) and in a young familial patient. They all showed the morphologically characteristic vacuoles containing osmiophilic membranous whorls and intracytoplasmic or intranuclear inclusions. There is a well-delineated bimodal age spectrum of IBM, with onset in the second and sixth decades, but otherwise the disorder seems to be a specific entity. Clinical, electrophysiologic, and morphologic features suggest a neurogenic origin in some ca… Show more

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Cited by 85 publications
(46 citation statements)
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“…Electron microscopic study of these inclusions revealed structures that resembled paramyxovirus nucleocapsid, which is suggestive of a possible pathogenic factor for chronic polymyositis (1). Similar histopathologic findings were reported subsequently by other investigators, and gradually, clinical features were .identified which appeared to distinguish the disease known as inclusion body myositis (IBM) (2)(3)(4)(5). Based on reported patient series, IBM in its fully developed form appears to have histopathologic and clinical features that differentiate it from idiopathic polymyositis or dermatomyositis.…”
supporting
confidence: 77%
See 1 more Smart Citation
“…Electron microscopic study of these inclusions revealed structures that resembled paramyxovirus nucleocapsid, which is suggestive of a possible pathogenic factor for chronic polymyositis (1). Similar histopathologic findings were reported subsequently by other investigators, and gradually, clinical features were .identified which appeared to distinguish the disease known as inclusion body myositis (IBM) (2)(3)(4)(5). Based on reported patient series, IBM in its fully developed form appears to have histopathologic and clinical features that differentiate it from idiopathic polymyositis or dermatomyositis.…”
supporting
confidence: 77%
“…Based on reported patient series, IBM in its fully developed form appears to have histopathologic and clinical features that differentiate it from idiopathic polymyositis or dermatomyositis. We report 4 cases of IBM, each presenting as treatment-resistant polymyositis. We suggest that IBM may be a more frequent cause of chronic inflammatory myopathy than was previously recognized and that it is a disorder capable of mimicking idiopathic polymyositis for prolonged periods of time.…”
mentioning
confidence: 99%
“…Posteriormente foram relatados diversos casos de MCIC, incluindo duas séries com mais de 30 pacientes, o que permitiu a caracterização da doença como entidade clínica distinta [16][17][18][19][20] . A identificação de famílias com MCIC transmitida de forma autossômica dominante ou recessiva permitiu a subdivisão da MCIC nas formas hereditária e esporádica 21,22 .…”
Section: Discussionunclassified
“…La afección del sensorio se examina clínicamente y con estudios electrofisiológicos y de neuroconducción, que evidencian la neuropatía axonal sensorial e incremento de la actividad polifásica motora (36,37). Los estudios de laboratorios pueden mostrar elevación de la CK sérica la cual puede estar normal o elevada hasta diez veces (38,39); los anticuerpos antinucleares pueden estar presentes en un 20% de los casos, pero usualmente están ausentes y un 20% de los pacientes pueden tener una gamapatía monoclonal indeterminada.…”
Section: Otros Desórdenes (Raros)unclassified